Scoping study on natural resources and climate change in Southeast Asia with a focus on agriculture. Final report

Climate change / Natural resources / Environmental effects / Agroecology / Agricultural production / Crops / Cropping systems / Farming systems / Livestock / Fisheries / Food security / Water management / Economic aspects / Rural poverty / Policy / Nutrient management / South East Asia / Cambodia / Laos / Thailand / Vietnam / Myanmar / China / Greater Mekong Subregion / Tonle Sap / Yunnan

Pre-service Teachers’ Impact on Student Learning: Planning, Teaching, and Assessing during Professional Practice

This paper reports a pilot study to investigate four pre-service teachers’ reports of their impact on student learning while they completed a four-week professional experience block. We used Hiebert, Morris, Berk, and Jansen’s (2007) framework for teacher preparation to analyse the how the participants planned, assessed and reflected on a lesson sequence. Data collected were the pre-service teachers’ learning diary entries completed during the four-week block and an online questionnaire and interview completed at the end of the teaching block. Results indicate that the pre-service teachers struggled to identify clear learning goals for students which adversely impacted their ability to plan their lessons and assess students’ learning. Implications for teacher education programs are discussed

Climate change, water and agriculture in the Greater Mekong subregion

Climate change / Adaptation / Indicators / Water resource management / River basins / Water availability / Water quality / Groundwater / Fisheries / Ecosystems / Water power / Population growth / Land use / Biofuels / Sea level / South East Asia / Cambodia / Laos / Myanmar / Thailand / Vietnam / China / Greater Mekong Subregion / Yunnan Province

Complete and Prolonged Response to Immune Checkpoint Blockade in POLE-Mutated Colorectal Cancer

Enid Robertson Logan Faculty Fellowship Fund6 month embargo; published online: 21 June 2019This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Inserting rights and justice into urban resilience : a focus on everyday risk

Resilience building has become a growing policy agenda, particularly for urban risk management. While much of the resilience agenda has been shaped by policies and discourses from the global North, its applicability for cities of the global south, particularly African cities, has not been sufficiently assessed. Focusing on rights of urban citizens as the object to be made resilient, rather than physical and ecological infrastructures, may help to address many of the root causes that characterize the unacceptable risks that urban residents face on a daily basis. Linked to this idea, we discuss four entry points for grounding a rights and justice orientation for urban resilience. First, notions of resilience must move away from narrow, financially-orientated risk analyses. Second, opportunities must be created for “negotiated resilience”, to allow for attention to processes that support these goals, as well as for the integration of diverse interests. Third, achieving resilience in ways that do justice to the local realities of diverse urban contexts necessitates taking into account endogenous, locally situated processes, knowledges and norms. And finally, urban resilience needs to be placed within the context of global systems, providing an opportunity for African contributions to help reimagine the role that cities might play in these global finance, politics and science processes

Climate change, water and agriculture in the Greater Mekong subregion

The impacts of climate change on agriculture and food production in Southeast Asia will be largely mediated through water, but climate is only one driver of change. Water resources in the region will be shaped by a complex mixture of social, economic and environmental factors. This report reviews the current status and trends in water management in the Greater Mekong Subregion; assesses likely impacts of climate change on water resources to 2050; examines water management strategies in the context of climate and other changes; and identifies priority actions for governments and communities to improve resilience of the water sector and safeguard food production

Hemispheric lateralization of white matter microstructure in children and its potential role in sensory processing dysfunction

Diffusion tensor imaging (DTI) studies have demonstrated white matter microstructural differences between the left and right hemispheres of the brain. However, the basis of these hemispheric asymmetries is not yet understood in terms of the biophysical properties of white matter microstructure, especially in children. There are reports of altered hemispheric white matter lateralization in ASD; however, this has not been studied in other related neurodevelopmental disorders such as sensory processing disorder (SPD). Firstly, we postulate that biophysical compartment modeling of diffusion MRI (dMRI), such as Neurite Orientation Dispersion and Density Imaging (NODDI), can elucidate the hemispheric microstructural asymmetries observed from DTI in children with neurodevelopmental concerns. Secondly, we hypothesize that sensory over-responsivity (SOR), a common type of SPD, will show altered hemispheric lateralization relative to children without SOR. Eighty-seven children (29 females, 58 males), ages 8–12 years, presenting at a community-based neurodevelopmental clinic were enrolled, 48 with SOR and 39 without. Participants were evaluated using the Sensory Processing 3 Dimensions (SP3D). Whole brain 3 T multi-shell multiband dMRI (b = 0, 1,000, 2,500 s/mm2) was performed. Tract Based Spatial Statistics were used to extract DTI and NODDI metrics from 20 bilateral tracts of the Johns Hopkins University White-Matter Tractography Atlas and the lateralization Index (LI) was calculated for each left–right tract pair. With DTI metrics, 12 of 20 tracts were left lateralized for fractional anisotropy and 17/20 tracts were right lateralized for axial diffusivity. These hemispheric asymmetries could be explained by NODDI metrics, including neurite density index (18/20 tracts left lateralized), orientation dispersion index (15/20 tracts left lateralized) and free water fraction (16/20 tracts lateralized). Children with SOR served as a test case of the utility of studying LI in neurodevelopmental disorders. Our data demonstrated increased lateralization in several tracts for both DTI and NODDI metrics in children with SOR, which were distinct for males versus females, when compared to children without SOR. Biophysical properties from NODDI can explain the hemispheric lateralization of white matter microstructure in children. As a patient-specific ratio, the lateralization index can eliminate scanner-related and inter-individual sources of variability and thus potentially serve as a clinically useful imaging biomarker for neurodevelopmental disorders

The Galactic Center with Roman

We advocate for a Galactic center (GC) field to be added to the Galactic Bulge Time Domain Survey (GBTDS). The new field would yield high-cadence photometric and astrometric measurements of an unprecedented ${\sim}$3.3 million stars toward the GC. This would enable a wide range of science cases, such as finding star-compact object binaries that may ultimately merge as LISA-detectable gravitational wave sources, constraining the mass function of stars and compact objects in different environments, detecting populations of microlensing and transiting exoplanets, studying stellar flares and variability in young and old stars, and monitoring accretion onto the central supermassive black hole. In addition, high-precision proper motions and parallaxes would open a new window into the large-scale dynamics of stellar populations at the GC, yielding insights into the formation and evolution of galactic nuclei and their co-evolution with the growth of the supermassive black hole. We discuss the possible trade-offs between the notional GBTDS and the addition of a GC field with either an optimal or minimal cadence. Ultimately, the addition of a GC field to the GBTDS would dramatically increase the science return of Roman and provide a legacy dataset to study the mid-plane and innermost regions of our Galaxy.Comment: 19 pages, 3 figures. Submitted to the NASA Roman Core Community Surveys White Paper Cal

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin