An optical-IR jet in 3C133

We report the discovery of a new optical-IR synchrotron jet in the radio galaxy 3C133 from our HST/NICMOS snapshot survey. The jet and eastern hotspot are well resolved, and visible at both optical and IR wavelengths. The IR jet follows the morphology of the inner part of the radio jet, with three distinct knots identified with features in the radio. The radio-IR SED's of the knots are examined, along with those of two more distant hotspots at the eastern extreme of the radio feature. The detected emission appears to be synchrotron, with peaks in the NIR for all except one case, which exhibits a power-law spectrum throughout.Comment: ApJ accepted. 14 pages, 6 figure

Evaluation of Non-linearity in MIR Spectroscopic Data for Compressed Learning

Mid-Infrared (MIR) spectroscopy has emerged as the most economically viable technology to determine milk values as well as to identify a set of animal phenotypes related to health, feeding, well-being and environment. However, Fourier transform-MIR spectra incurs a significant amount of redundant data. This creates critical issues such as increased learning complexity while performing Fog and Cloud based data analytics in smart farming. These issues can be resolved through data compression using unsupervisory techniques like PCA, and perform analytics in the compressed-domain i.e. without de-compressing. Compression algorithms should preserve non-linearity of MIRS data (if exists), since emerging advanced learning algorithms can improve their prediction accuracy. This study has investigated the non-linearity between the feature variables in the measurement-domain as well as in two compressed domains using standard Linear PCA and Kernel PCA. Also the non-linearity between the feature variables and the commonly used target milk quality parameters (Protein, Lactose, Fat) has been analyzed. The study evaluates the prediction accuracy using PLS and LS-SVM respectively as linear and non-linear predictive models

The nuclear envelope as a chromatin organizer

In the past 15 years our perception of nuclear envelope function has evolved perhaps nearly as much as the nuclear envelope itself evolved in the last 3 billion years. Historically viewed as little more than a diffusion barrier between the cytoplasm and the nucleoplasm, the nuclear envelope is now known to have roles in the cell cycle, cytoskeletal stability and cell migration, genome architecture, epigenetics, regulation of transcription, splicing and DNA replication. Here we will review both what is known and what is speculated about the role of the nuclear envelope in genome organization, particularly with respect to the positioning and repositioning of genes and chromosomes within the nucleus during differentiation

A Meta-Learning Method for Concept Drift

The knowledge hidden in evolving data may change with time, this issue is known as concept drift. It often causes a learning system to decrease its prediction accuracy. Most existing techniques apply ensemble methods to improve learning performance on concept drift. In this paper, we propose a novel meta learning approach for this issue and develop a method: Multi-Step Learning (MSL). In our method, a MSL learner is structured in a recursive manner, which contains all the base learners maintained in a hierarchy, ensuring the learned concepts are traceable. We evaluated MSL and two ensemble techniques on three synthetic datasets, which contain a number of drastic concept drifts. The experimental results show that the proposed method generally performs better than the ensemble techniques in terms of prediction accuracy

Cellular taxonomy and spatial organization of the murine ventral posterior hypothalamus.

The ventral posterior hypothalamus (VPH) is an anatomically complex brain region implicated in arousal, reproduction, energy balance, and memory processing. However, neuronal cell type diversity within the VPH is poorly understood, an impediment to deconstructing the roles of distinct VPH circuits in physiology and behavior. To address this question, we employed a droplet-based single-cell RNA sequencing (scRNA-seq) approach to systematically classify molecularly distinct cell populations in the mouse VPH. Analysis of \u3e16,000 single cells revealed 20 neuronal and 18 non-neuronal cell populations, defined by suites of discriminatory markers. We validated differentially expressed genes in selected neuronal populations through fluorescence in situ hybridization (FISH). Focusing on the mammillary bodies (MB), we discovered transcriptionally-distinct clusters that exhibit neuroanatomical parcellation within MB subdivisions and topographic projections to the thalamus. This single-cell transcriptomic atlas of VPH cell types provides a resource for interrogating the circuit-level mechanisms underlying the diverse functions of VPH circuits

Parallel Programming with Migratable Objects: Charm++ in Practice

The advent of petascale computing has introduced new challenges (e.g. Heterogeneity, system failure) for programming scalable parallel applications. Increased complexity and dynamism in science and engineering applications of today have further exacerbated the situation. Addressing these challenges requires more emphasis on concepts that were previously of secondary importance, including migratability, adaptivity, and runtime system introspection. In this paper, we leverage our experience with these concepts to demonstrate their applicability and efficacy for real world applications. Using the CHARM++ parallel programming framework, we present details on how these concepts can lead to development of applications that scale irrespective of the rough landscape of supercomputing technology. Empirical evaluation presented in this paper spans many miniapplications and real applications executed on modern supercomputers including Blue Gene/Q, Cray XE6, and Stampede

RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first-second trimester transition.

The human placenta is exposed to major environmental changes towards the end of the first trimester associated with full onset of the maternal arterial placental circulation. Changes include a switch from histotrophic to hemotrophic nutrition, and a threefold rise in the intraplacental oxygen concentration. We evaluated their impact on trophoblast development and function using RNA-sequencing (RNA-Seq) and DNA-methylation analyses performed on the same chorionic villous samples at 7-8 (n=8) and 13-14 (n=6) weeks of gestation. Reads were adjusted for fetal sex. Most DEGs were associated with protein processing in the endoplasmic reticulum (ER), hormone secretion, transport, extracellular matrix, vasculogenesis, and reactive oxygen species metabolism. Transcripts higher in the first trimester were associated with synthesis and ER processing of peptide hormones, and glycolytic pathways. Transcripts encoding proteins mediating transport of oxygen, lipids, protein, glucose, and ions were significantly increased in the second trimester. The motifs of CBX3 and BCL6 were significantly overrepresented, indicating the involvement of these transcription factor networks in the regulation of trophoblast migration, proliferation and fusion. These findings are consistent with a high level of cell proliferation and hormone secretion by the early placenta to secure implantation in a physiological low-oxygen environment

RNA-Seq reveals changes in human placental metabolism, transport and endocrinology across the first-second trimester transition.

The human placenta is exposed to major environmental changes towards the end of the first trimester associated with full onset of the maternal arterial placental circulation. Changes include a switch from histotrophic to hemotrophic nutrition, and a threefold rise in the intraplacental oxygen concentration. We evaluated their impact on trophoblast development and function using RNA-sequencing (RNA-Seq) and DNA-methylation analyses performed on the same chorionic villous samples at 7-8 (n=8) and 13-14 (n=6) weeks of gestation. Reads were adjusted for fetal sex. Most DEGs were associated with protein processing in the endoplasmic reticulum (ER), hormone secretion, transport, extracellular matrix, vasculogenesis, and reactive oxygen species metabolism. Transcripts higher in the first trimester were associated with synthesis and ER processing of peptide hormones, and glycolytic pathways. Transcripts encoding proteins mediating transport of oxygen, lipids, protein, glucose, and ions were significantly increased in the second trimester. The motifs of CBX3 and BCL6 were significantly overrepresented, indicating the involvement of these transcription factor networks in the regulation of trophoblast migration, proliferation and fusion. These findings are consistent with a high level of cell proliferation and hormone secretion by the early placenta to secure implantation in a physiological low-oxygen environment

Batable ground

The poems that follow were written during and after a series of walks around the border town of Berwick-Upon-Tweed which has an architectural heritage marked by tension between England and Scotland. There is a medieval castle which changed hands fifteen times before falling into dis-use, Elizabethan Ramparts encircle the town and the Old Bridge was commissioned by James VI of Scotland whilst on the way to be crowned James I of England. These heritage features suddenly took on new significance during the Scottish Independence Referendum debate as submerged histories returned to the surface; I was in Berwick on the day voting took place, it was a quiet and misty day, the town seemed to be holding its breath. The poems are open form, composed by grid and field, making use of found texts and historical documents. They explore the entangled history of England and Scotland for those who dwell in the border