Pessoine and spinosine, two catecholic berbines from Annona spinescens

The trunk bark and roots of #Annona spinescens$ have been investigated for their alkaloid content. Two new berbine alkaloids, pessoine and spinosine, have been isolated from the bark, and their structures were elucidated by spectroscopic methods. Eight known isoquinoline alkaloids were also obtained. The trypanocidal and antileishmanial activities of these isolated compounds have been investigated. (Résumé d'auteur

New prenylated quinones from Peperomia galioides

Two new prenylated quinones, piperogalone and galopiperone, and a new prenylated dihydroquinone, hydropiperone, were isolated from #Peperomia galioides H.B.K (#Piperaceae). Hydropiperone exhibited potent antiparasitic activity against three species of #Leishmania$. (Résumé d'auteur

J Clin Med

BACKGROUND: During this pandemic situation, some studies have led to hasty conclusions about Corona Virus Disease-19 (COVID-19) treatment, due to a lack of methodology. This pedagogic study aimed to highlight potential biases in research on COVID-19 treatment. METHODS: We evaluate the effect of coffee's active part, 1,3,7-trimethylxanthine (TMX) on patients with COVID-19. A cohort of 93 patients, with a diagnosis of COVID-19 is analyzed. RESULTS: TMX group and control group included, respectively, 26 and 67 patients. In the TMX group, patients had a median length of stay in hospital of 5.5 days shorter than in the control group (9.5 vs. 15 days, p < 0.05). Patients in the control group were more severe than patients in the TMX group with a significantly higher National Early Warning Score 2 (NEWS-2 score) (8 vs. 6, p = 0.002). CONCLUSIONS: Multiple biases prevents us from concluding to an effect of coffee on COVID-19. Despite an important social pressure during this crisis, methodology and conscientiousness are the best way to avoid hasty conclusions that can be deleterious for patients. Identifier: NCT04395742