Patients' practices and experiences of using nebuliser therapy in the management of COPD at home.

How patients use their nebulisers at home is vital to ensure effective treatment and optimal health outcomes for patients with chronic obstructive pulmonary disease (COPD). The aim of the study was to identify the practicalities and problems associated with nebuliser use by patients with COPD at home, which may impact on the safety and effectiveness of therapy

Land-based climate solutions for the United States

Funding Information: We thank many colleagues for helpful discussion and feedback during the preparation of this analysis, anonymous reviewers for constructive criticism, and J.L. Schuette for help with data assembly. Financial support was provided by the U.S. Department of Energy Great Lakes Bioenergy Research Center (Award DE‐SC0018409), the U.S. National Science Foundation Long‐term Ecological Research Program (DEB 1832042), the USDA Long‐term Agroecosystem Research program, and Michigan State University AgBioResearch. Additional support (PS) is from the Soils‐R‐GGREAT (NE/P019455/1) and CIRCASA (Agreement 774378) projects of the European Union‘s Horizon 2020 Research and Innovation Programme (Award 774378); and (KP) the U.S. Department of Energy Advanced Research Projects Agency‐Energy program (Award DE‐AR0000826). KP serves as a part‐time advisor to Indigo Ag, Inc., a company that markets soil carbon sequestration credits. The authors declare no other potential conflicts of interest. Publisher Copyright: © 2022 The Authors. Global Change Biology published by John Wiley & Sons Ltd.Peer reviewedPublisher PD

Direct measurement of the intermolecular forces confining a single molecule in an entangled polymer solution

We use optical tweezers to directly measure the intermolecular forces acting on a single polymer imposed by surrounding entangled polymers (115 kbp DNA, 1 mg/ml). A tube-like confining field was measured in accord with the key assumption of reptation models. A time-dependent harmonic potential opposed transverse displacement, in accord with recent simulation findings. A tube radius of 0.8 microns was determined, close to the predicted value (0.5 microns). Three relaxation modes (~0.4, 5 and 30 s) were measured following transverse displacement, consistent with predicted relaxation mechanisms.Comment: 11 pages, 3 figure

First starlight spectrum captured using an integrated photonic micro-spectrograph

Photonic technologies have received growing consideration for incorporation into next-generation astronomical instrumentation, owing to their miniature footprint and inherent robustness. In this paper we present results from the first on-telescope demonstration of a miniature photonic spectrograph for astronomy, by obtaining spectra spanning the entire H-band from several stellar targets. The prototype was tested on the 3.9 m Anglo-Australian telescope. In particular, we present a spectrum of the variable star Pi 01 Gru, with observed CO molecular absorption bands, at a resolving power R = 2500 at 1600 nm. Furthermore, we successfully demonstrate the simultaneous acquisition of multiple spectra with a single spectrograph chip by using multiple fibre inputs.Comment: 5 Pages, 4 Figures; A&A, Volume 544 (2012

Construction and testing of the optical bench for LISA pathfinder

eLISA is a space mission designed to measure gravitational radiation over a frequency range of 0.1–100 mHz (European Space Agency LISA Assessment Study Report 2011). It uses laser interferometry to measure changes of order $10\,{\rm pm /\sqrt{Hz}}$ in the separation of inertial test masses housed in spacecraft separated by 1 million km. LISA Pathfinder (LPF) is a technology demonstrator mission that will test the key eLISA technologies of inertial test masses monitored by laser interferometry in a drag-free spacecraft. The optical bench that provides the interferometry for LPF must meet a number of stringent requirements: the optical path must be stable at the few ${\rm pm /\sqrt{Hz}}$ level; it must direct the optical beams onto the inertial masses with an accuracy of better than ±25 μm, and it must be robust enough not only to survive launch vibrations but to achieve full performance after launch. In this paper we describe the construction and testing of the flight optical bench for LISA Pathfinder that meets all the design requirements

Staphylococcus aureus in the oral cavity: a three-year retrospective analysis of clinical laboratory data

OBJECTIVE: A retrospective analysis of laboratory data to investigate the isolation of Staphylococcus aureus from the oral cavity and facial area in specimens submitted to a regional diagnostic oral microbiology laboratory. METHODS: A hand search of laboratory records for a three-year period (1998-2000) was performed for specimens submitted to the regional diagnostic oral microbiology laboratory based at Glasgow Dental Hospital and School. Data were collected from forms where S. aureus was isolated. These data included demographics, referral source, specimen type, methicillin susceptibility and clinical details. RESULTS: For the period 1998-2000, there were 5,005 specimens submitted to the laboratory. S. aureus was isolated from 1,017 specimens, of which 967 (95%) were sensitive to methicillin (MSSA) and 50 (5%) were resistant to methicillin (MRSA). The 1,017 specimens were provided from 615 patients. MRSA was isolated from 37 (6%) of patients. There was an increasing incidence of S. aureus with age, particularly in the greater than 70 years age group. The most common specimen from which MSSA was isolated was an oral rinse (38%) whilst for MRSA isolates this was a tongue swab (28%). The clinical condition most commonly reported for MSSA isolates was angular cheilitis (22%). Erythema, swelling, pain or burning of the oral mucosa was the clinical condition most commonly reported for MRSA isolates (16%). Patients from whom the MSSA isolates were recovered were most commonly (55%) seen in the oral medicine clinic at the dental hospital, whilst patients with MRSA were more commonly seen in primary care settings such as nursing homes, hospices and general dental practice (51%). CONCLUSION: In line with more recent surveys, this retrospective study suggests that S. aureus may be a more frequent isolate from the oral cavity than hitherto suspected. A small proportion of the S. aureus isolates were MRSA. There were insufficient data available to determine whether the S. aureus isolates were colonising or infecting the oral cavity. However, the role of S. aureus in several diseases of the oral mucosa merits further investigation

Molecular Hydrogen and Global Star Formation Relations in Galaxies

(ABRIDGED) We use hydrodynamical simulations of disk galaxies to study relations between star formation and properties of the molecular interstellar medium (ISM). We implement a model for the ISM that includes low-temperature (T<10^4K) cooling, directly ties the star formation rate to the molecular gas density, and accounts for the destruction of H2 by an interstellar radiation field from young stars. We demonstrate that the ISM and star formation model simultaneously produces a spatially-resolved molecular-gas surface density Schmidt-Kennicutt relation of the form Sigma_SFR \propto Sigma_Hmol^n_mol with n_mol~1.4 independent of galaxy mass, and a total gas surface density -- star formation rate relation Sigma_SFR \propto Sigma_gas^n_tot with a power-law index that steepens from n_tot~2 for large galaxies to n_tot>~4 for small dwarf galaxies. We show that deviations from the disk-averaged Sigma_SFR \propto Sigma_gas^1.4 correlation determined by Kennicutt (1998) owe primarily to spatial trends in the molecular fraction f_H2 and may explain observed deviations from the global Schmidt-Kennicutt relation.Comment: Version accepted by ApJ, high-res version available at http://kicp.uchicago.edu/~brant/astro-ph/molecular_ism/rk2007.pd

Miniaturized data loggers and computer programming improve seabird risk and damage assessments for marine oil spills in Atlantic Canada

Obtaining useful information on marine birds that can aid in oil spill (and other hydrocarbon release) risk and damage assessments in offshore environments is challenging. Technological innovations in miniaturization have allowed archival data loggers to be deployed successfully on marine birds vulnerable to hydrocarbons on water. A number of species, including murres (both Common, Uria aalge, and Thick-billed, U. lomvia) have been tracked using geolocation devices in eastern Canada, increasing our knowledge of the seasonality and colony-specific nature of their susceptibility to oil on water in offshore hydrocarbon production areas and major shipping lanes. Archival data tags are starting to resolve questions around behaviour of vulnerable seabirds at small spatial scales relevant to oil spill impact modelling, specifically to determine the duration and frequency at which birds fly at sea. Advances in data capture methods using voice activated software have eased the burden on seabird observers who are collecting increasingly more detailed information on seabirds during ship-board and aerial transects. Computer programs that integrate seabird density and bird behaviour have been constructed, all with a goal of creating more credible seabird oil spill risk and damage assessments. In this paper, we discuss how each of these technological and computing innovations can help define critical inputs into seabird risk and damage assessments, and when combined, can provide a more realistic understanding of the impacts to seabirds from any hydrocarbon release