A computational study of thrust augmenting ejectors based on a viscous-inviscid approach

A viscous-inviscid interaction technique is advocated as both an efficient and accurate means of predicting the performance of two-dimensional thrust augmenting ejectors. The flow field is subdivided into a viscous region that contains the turbulent jet and an inviscid region that contains the ambient fluid drawn into the device. The inviscid region is computed with a higher-order panel method, while an integral method is used for the description of the viscous part. The strong viscous-inviscid interaction present within the ejector is simulated in an iterative process where the two regions influence each other en route to a converged solution. The model is applied to a variety of parametric and optimization studies involving ejectors having either one or two primary jets. The effects of nozzle placement, inlet and diffuser shape, free stream speed, and ejector length are investigated. The inlet shape for single jet ejectors is optimized for various free stream speeds and Reynolds numbers. Optimal nozzle tilt and location are identified for various dual-ejector configurations

Simultaneous determination of seven β-lactam antibiotics in human plasma for therapeutic drug monitoring and pharmacokinetic studies

There is strong evidence in literature supporting the benefit of monitoring plasma concentrations of β-lactam antibiotics in the critically ill to ensure appropriateness of dosing. The objective of this work was to develop a method for the simultaneous determination of total concentrations piperacillin, benzylpenicillin, flucloxacillin, meropenem, ertapenem, cephazolin and ceftazidime in human plasma. Sample preparation involved protein precipitation with acetonitrile containing 0.1% formic acid and subsequent dilution of supernatant with 0.1% formic acid in water. Chromatographic separation was achieved on a reversed phase column (C18, 2.6. μm, 2.1. ×. 50. mm) via gradient elution using water and acetonitrile, each containing 0.1% formic acid, as mobile phase. Tandem mass spectrometry (MSMS) analysis was performed, after electrospray ionization in the positive mode, with multiple reaction monitoring (MRM). The method is accurate with the inter-day and intra-day accuracies of quality control samples (QCs) ranging from 95 to 107% and 95 to 108%, respectively. It is also precise with intra-day and inter-day coefficient of variations ranging from 4 to 12% and 5 to 14%, respectively. The lower limit of quantification was 0.1. μg/mL for each antibiotic except flucloxacillin (0.25. μg/mL). Recovery was greater than 96% for all analytes except for ertapenem (78%). Coefficients of variation for the matrix effect were less than 10% over the six batches of plasma. Analytes were stable over three freeze-thaw cycles, and for reasonable hours on the bench top as well as post-preparation. This novel liquid chromatography tandem mass spectrometry method proved accurate, precise and applicable for therapeutic drug monitoring and pharmacokinetic studies of the selected β-lactam antibiotics

Exploratory Analysis of ‘Other Revenue’ Impact on Full and Limited Service Hotel NOI

Hotel ‘Other Revenue’ category is often overlooked as a means to improve NOI through heightened profit margin contribution. This study investigated the impact of ‘Other Revenue’ on NOI profit margin in 3,271 full and limited service U.S. hotels. A decision tree analysis was conducted to gain insight of various departmental expense ratios (independent variables) to NOI (dependent variable). Results indicated room and undistributed expense ratios had a greater impact on NOI than ‘Other Revenue’ in limited-service hotels, while food and beverage, undistributed, and room expense ratios had a greater impact on NOI profit margin than ‘Other Revenue’ in full-service hotels

Deconfinement at finite chemical potential

In a confining, renormalisable, Dyson-Schwinger equation model of two-flavour QCD we explore the chemical-potential dependence of the dressed-quark propagator, which provides a means of determining the behaviour of the chiral and deconfinement order parameters, and low-energy pion observables. We find coincident, first order deconfinement and chiral symmetry restoration transitions at \mu_c = 375 MeV. f_\pi is insensitive to \mu until \mu \approx \mu_0 = 0.7 mu_c when it begins to increase rapidly. m_\pi is weakly dependent on \mu, decreasing slowly with \mu and reaching a minimum 6% less than its \mu=0 value at \mu=\mu_0. In a two-flavour free-quark gas at \mu=\mu_c the baryon number density would be approximately 3 \rho_0, where \rho_0=0.16 fm^{-3}; while in such a gas at \mu_0 the density is \rho_0.Comment: 11 pages, 3 figures, epsfig.sty, elsart.st

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A New Methodology for Assessing Macromolecular Click Reactions and Its Application to Amine--Tertiary Isocyanate Coupling for Polymer Ligation.

Click reactions have provided access to an array of remarkably complex polymer architectures. However, the term "click" is often applied inaccurately to polymer ligation reactions that fail to respect the criteria that typify a true "click" reaction. With the purpose of providing a universal way to benchmark polymer-polymer coupling efficiency at equimolarity and thus evaluate the fulfilment of click criteria, we report a simple one-pot methodology involving the homodicoupling of α-end-functionalized polymers using a small-molecule bifunctional linker. A combination of SEC analysis and chromatogram deconvolution enables straightforward quantification of the coupling efficiency. We subsequently employ this methodology to evaluate an overlooked candidate for the click reaction family: the addition of primary amines to α-tertiary isocyanates (α-(t)NCO). Using our bifunctional linker coupling strategy, we show that the amine-(t)NCO reaction fulfills the criteria for a polymer-polymer click reaction, achieving rapid, chemoselective, and quantitative coupling at room temperature without generating any byproducts. We demonstrate that amine-(t)NCO coupling is faster and more efficient than the more common amine-tertiary active ester coupling under equivalent conditions. Additionally, we show that the α-(t)NCO end group is unprecedentedly stable in aqueous media. Thus, we propose that the amine-(t)NCO ligation is a powerful new click reaction for efficient macromolecular coupling.Dr Maarten Danial for providing the cyclic peptide.This is the final version of the article. It first appeared from the American Chemical Society via http://dx.doi.org/10.1021/jacs.5b1183