The Development and Performance Characterization of the Next Generation Electronics Designed for the Antarctic Impulsive Transient Antenna.

Ph.D. Thesis. University of Hawaiʻi at Mānoa 2017

Measurement of Galactic 26Al with the Compton Spectrometer and Imager

International audienceThe Compton Spectrometer and Imager (COSI) is a balloon-borne compact Compton telescope designed to survey the 0.2-5 MeV sky. COSI's energy resolution of ~0.2% at 1.8 MeV, single-photon reconstruction, and wide field of view make it capable of studying astrophysical nuclear lines, particularly the 1809 keV γ-ray line from decaying Galactic 26Al. Most 26Al originates in massive stars and core-collapse supernova nucleosynthesis, but the path from stellar evolution models to Galaxy-wide emission remains unconstrained. In 2016, COSI had a successful 46 day flight on a NASA superpressure balloon. Here, we detail the first search for the 1809 keV 26Al line in the COSI 2016 balloon flight using a maximum-likelihood analysis. We find a Galactic 26Al flux of (8.6 ± 2.5) × 10-4 ph cm-2 s-1 within the Inner Galaxy (∣ℓ∣ ≤ 30°, ∣b∣ ≤ 10°) with 3.7σ significance above background. Within uncertainties, this flux is consistent with expectations from previous measurements by SPectrometer on INTEGRAL (SPI) and the Compton Telescope on the Compton Gamma-Ray Observatory (COMPTEL). This analysis demonstrates COSI's powerful capabilities for studies of γ-ray lines and underscores the scientific potential of future compact Compton telescopes. In particular, the next iteration of COSI as a NASA Small Explorer satellite has recently been approved for launch in 2025

Imaging the 511 keV positron annihilation sky with COSI

International audienceThe balloon-borne Compton Spectrometer and Imager (COSI) had a successful 46-day flight in 2016. The instrument is sensitive to photons in the energy range 0.2–5 MeV. Compton telescopes have the advantage of a unique imaging response and provide the possibility of strong background suppression. With its high-purity germanium detectors, COSI can precisely map γ-ray line emission. The strongest persistent and diffuse γ-ray line signal is the 511 keV emission line from the annihilation of electrons with positrons from the direction of the Galactic center. While many sources have been proposed to explain the amount of positrons, , the true contributions remain unsolved. In this study, we aim at imaging the 511 keV sky with COSI and pursue a full-forward modeling approach, using a simulated and binned imaging response. For the strong instrumental background, we describe an empirical approach to take the balloon environment into account. We perform two alternative methods to describe the signal: Richardson–Lucy deconvolution, an iterative method toward the maximum likelihood solution, and model fitting with predefined emission templates. Consistently with both methods, we find a 511 keV bulge signal with a flux between 0.9 and , confirming earlier measurements, and also indications of more extended emission. The upper limit we find for the 511 keV disk, , is consistent with previous detections. For large-scale emission with weak gradients, coded aperture mask instruments suffer from their inability to distinguish isotropic emission from instrumental background, while Compton telescopes provide a clear imaging response, independent of the true emission

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10−8- 1.2 ×10−43). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3×10−4). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p = 4.3×10−3, n = 22,044), increased triglycerides (p = 2.6×10−14, n = 93,440), increased waist-to-hip ratio (p = 1.8×10−5, n = 77,167), increased glucose two hours post oral glucose tolerance testing (p = 4.4×10−3, n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL- cholesterol concentrations (p = 4.5×10−13, n = 96,748) and decreased BMI (p = 1.4×10−4, n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance

Searching for VHE gamma-ray emission associated with IceCube neutrino alerts using FACT, H.E.S.S., MAGIC, and VERITAS

The realtime follow-up of neutrino events is a promising approach to search for astrophysical neutrino sources. It has so far provided compelling evidence for a neutrino point source: the flaring gamma-ray blazar TXS 0506+056 observed in coincidence with the high-energy neutrino IceCube-170922A detected by IceCube. The detection of very-high-energy gamma rays (VHE, E&gt;100GeV E &gt; 100 G e V ) from this source helped establish the coincidence and constrained the modeling of the blazar emission at the time of the IceCube event. The four major imaging atmospheric Cherenkov telescope arrays (IACTs) - FACT, H.E.S.S., MAGIC, and VERITAS - operate an active follow-up program of target-of-opportunity observations of neutrino alerts sent by IceCube. This program has two main components. One are the observations of known gamma-ray sources around which a cluster of candidate neutrino events has been identified by IceCube (Gamma-ray Follow-Up, GFU). Second one is the follow-up of single high-energy neutrino candidate events of potential astrophysical origin such as IceCube-170922A. GFU has been recently upgraded by IceCube in collaboration with the IACT groups. We present here recent results from the IACT follow-up programs of IceCube neutrino alerts and a description of the upgraded IceCube GFU system