Tratamento cirúrgico das lesões traumáticas do plexo braquial em adultos: uma visão geral

Traumatic injuries to the brachial plexus in adults are severely debilitating. They generally affect young individuals. A thorough understanding of the anatomy, clinical evaluation, imaging and electrodiagnostic assessments, treatment options and proper timing of surgical interventions will enable nerve surgeons to offer optimal care to patients. Advances in microsurgical technique have improved the outcome for many of these patients. The treatment options offer patients with brachial plexus injuries the possibility of achieving elbow flexion, shoulder stability with limited abduction and the hope of limited but potentially useful hand function.As lesões traumáticas do plexo braquial em adultos são severamente debilitantes e, em geral, afetam indivíduos jovens. Uma ampla compreensão da anatomia, da avaliação clínica, dos estudos eletrodiagnósticos e por imagem, das opções de tratamento e do momento apropriado para o tratamento cirúrgico irá permitir que o cirurgião de nervos ofereça o tratamento ideal ao paciente. Os avanços na técnica microcirúrgica melhoraram os resultados para muitos desses pacientes. As opções de tratamento oferecem aos pacientes com lesões do plexo braquial a possibilidade de obter flexão do cotovelo, estabilidade do ombro com abdução limitada e a esperança de função limitada mas potencialmente útil da mão

A study of the effect of rotational mixing on massive stars evolution: Surface abundances of Galactic O7-8 giant stars

Context. Massive star evolution remains only partly constrained. In particular, the exact role of rotation has been questioned by puzzling properties of OB stars in the Magellanic Clouds. Aims. Our goal is to study the relation between surface chemical composition and rotational velocity, and to test predictions of evolutionary models including rotation. Methods. We have performed a spectroscopic analysis of a sample of fifteen Galactic O7-8 giant stars. This sample is homogeneous in terms of mass, metallicity and evolutionary state. It is made of stars with a wide range of projected rotational velocities. Results. We show that the sample stars are located on the second half of the main sequence, in a relatively narrow mass range (25-40 M⊙ ). Almost all stars with projected rotational velocities above 100 km s -1 have N/C ratios about ten times the initial value. Below 100 km s -1 a wide range of N/C values is observed. The relation between N/C and surface gravity is well reproduced by various sets of models. Some evolutionary models including rotation are also able to consistently explain slowly rotating, highly enriched stars. This is due to differential rotation which efficiently transports nucleosynthesis products and allows the surface to rotate slower than the core. In addition, angular momentum removal by winds amplifies surface braking on the main sequence. Comparison of the surface composition of O7-8 giant stars with a sample of B stars with initial masses about four times smaller reveal that chemical enrichment scales with initial mass, as expected from theory. Conclusions. Although evolutionary models that include rotation face difficulties in explaining the chemical properties of O- and B-type stars at low metallicity, some of them can consistently account for the properties of main-sequence Galactic O stars in the mass range 25-40 M ⊙.Instituto de Astrofísica de La Plat

Increasing the dimension of linear systems solved by classical or quantum binary optimization: A new method to solve large linear equation systems

Recently, binary optimization has become an attractive research topic due to the development of quantum computing and specialized classical systems inspired by quantum computing. These hardware systems promise to speed up the computation significantly. In this work, we propose a new method to solve linear systems written as a binary optimization problem. The procedure solves the problem efficiently and allows it to handle large linear systems. Our approach is founded on the geometry of the original linear problem and resembles the gradient conjugate method. The conjugated directions used can significantly improve the algorithm's convergence rate. We also show that a partial knowledge of the intrinsic geometry of the problem can divide the original problem into independent sub-problems of smaller dimensions. These sub-problems can then be solved using quantum or classical solvers. Although determining the geometry of the problem has an additional computational cost, it can substantially improve the performance of our method compared to previous implementations.Comment: 12 pages, 10 figure

Histologic and Histomorphometric Analysis of Posterior Region of the Human Temporomandibular Disc

Objective The aim of this study was to analyze histologic and histomorphometric features of the articular disc in groups with and without disc displacement. Study design A sample of 39 temporomandibular joints TMJs (31 case specimens, 8 control specimens) from 28 patients (mean age 31.2 years) were recruited for this study. The patients were considered to be affected and treated surgically with disc repositioning when presenting painful clinical signs of disc displacement after unsuccessful nonsurgical treatment for at least 6 months. Of the control patients, 4 presented condyle fracture which required opening to be reduced for treatment, and 4 displayed active condyle hyperplasia. The posterior region of the disc was removed and sent for histologic and histomorphometric analysis. Histologic (hematoxylin-eosin) and histomorphometric (picro-Sirius red) analyses were performed. Statistically significant differences between the analyzed groups were accessed through the chi-squared test (P ≤ .05). The Mann-Whitney U test was used to observe the differences between mean values when variables did not present normal distribution [Kolmogorov-Smirnov(a) test]. Results There were no significant differences between the groups in relation to the parameters studied by histologic and histomorphometric analysis (using or not using polarization). Conclusions To the limits of this study, there were no significant histologic and histomorphometric differences in the articular disc between groups with and without TMJ dysfunction

Urinary iodine in patients with auto-immune thyroid disorders in Santo andré, SP, is comparable to normal controls and has been steady for the last 10 years

OBJECTIVE: Evaluate whether the increase of iodine in the diet would be the triggering factor for auto-immune thyropathies in the city of Santo André, SP. METHODS: Urinary iodine was determined in samples isolated from 58 patients, divided in 4 Groups, and in 13 normal individuals (controls). RESULTS: Urinary Iodine: Group 1 - hyperthyroidism = 203.5±152.71 µg/ L(mean±sd); Group 2 - hypothyroidism = 258.31±148,2 µg/L; Group 3 - chronic auto-immune thyroiditis = 244.29±191.6 µg/L; group 4 (Amiodarone) = 1157.5±261.8 µg/L; Group 5 - Controls = 262.31±146.2 µg/L. On comparing the means of urinary iodine among the groups, the means for groups 1, 2, 3, and 5 did not present significant differences (p>0.05), and all differed from group 4 (p 0,05) e todos diferiram do grupo 4 (p < 0,05). A iodúria dos grupos 1, 2, 3 e 5, obtida em 2002 e 2003, não diferiram dos valores determinados em 1994 em escolares em Santo André. CONCLUSÃO: Este estudo evidencia que o iodo não deve ser considerado o agente responsável pelas tireopatias autoimunes em Santo André, e outros fatores ambientais devem ser investigados.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade de São Paulo Departamento de Clínica Médica Disciplina de EndocrinologiaUniversidade de São Paulo (USP) Faculdade de Medicina Departamento de Saúde da Coletividade da Faculdade de Medicina da Fundação ABCUniversidade Federal de São Paulo (UNIFESP) Departamento d Medicina, Escola Paulista de Medicina Disciplina de EndocrinologiaUNIFESP, Depto. d Medicina, Escola Paulista de Medicina Disciplina de EndocrinologiaSciEL

Chemical Constituents and Evaluation of Antimicrobial and Cytotoxic Activities of Kielmeyera coriacea

Many essential oils (EOs) of different plant species possess interesting antimicrobial effects on buccal microorganisms and cytotoxic properties. EOs of Kielmeyera coriacea Mart. & Zucc. were analyzed by gas chromatography coupled to mass spectrometry (GC-MS). The EO from leaves is rich in sesquiterpenes hydrocarbons and oxygenated sesquiterpenes. The three major compounds identified were germacrene-D (24.2%), (E)-caryophyllene (15.5%), and bicyclogermacrene (11.6%). The inner bark EO is composed mainly of sesquiterpenes hydrocarbons and the major components are alpha-copaene (14.9%) and alpha-(E)-bergamotene (13.0%). The outer bark EO is composed mainly of oxygenated sesquiterpenes and long-chain alkanes, and the major components are alpha-eudesmol (4.2%) and nonacosane (5.8%). The wood EO is mainly composed of long-chain alkanes and fatty acids, and the major components are nonacosane (9.7%) and palmitic acid (16.2%). The inner bark EO showed the strongest antimicrobial activity against the anaerobic bacteria Prevotella nigrescens (minimum inhibitory concentration-MIC of 50 µg mL−1). The outer bark and wood EOs showed MICs of 100 µg mL−1 for all aerobic microorganisms tested. The EOs presented low toxicity to Vero cells. These results suggest that K. coriacea, a Brazilian plant, provide initial evidence of a new and alternative source of substances with medicinal interest

Host Plant Record for the Fruit Flies, Anastrepha fumipennis and A. nascimentoi (Diptera, Tephritidae)

The first host plant record for Anastrepha fumipennis Lima (Diptera: Tephritidae) in Geissospermum laeve (Vell.) Baill (Apocynaceae) and for A. nascimentoi Zucchi found in Cathedra bahiensis Sleumer (Olacaceae) was determined in a host plant survey of fruit flies undertaken at the “Reserva Natural da Companhia Vale do Rio Doce”. This reserve is located in an Atlantic Rain Forest remnant area, in Linhares county, state of Espírito Santo, Brazil. The phylogenetic relationships of Anastrepha species and their hosts are discussed. The occurrence of these fruit fly species in relation to the distribution range of their host plants is also discussed