LHC bounds on large extra dimensions

We derive new dominant bounds on the coefficient of the effective operator generated by tree-level graviton exchange in large extra dimensions from pp \rightarrow jj data at LHC: M_T > 2.1TeV (ATLAS after 3.1/pb of integrated luminosity), M_T > 3.4 TeV (CMS after 36/pb), MT > 3.2 TeV (ATLAS after 36/pb). We clarify the role of on-shell graviton exchange and compare the full graviton amplitude to ATLAS data, setting bounds on the fundamental quantum-gravity scale.Comment: 16 pages, 6 figures. v2: updated with CMS data. v3: updated with ATLAS data at 36/pb; final published versio

Different Roles Played by Adipose-Derived Stem Cells in Peripheral Nerve Regeneration: State of the Art.

Peripheral nerve injury is commonly attributable to traffic and industrial accidents, natural disasters, and war damage. Destruction of nerve fibers results in denervation of targeted muscles, whic..

Minute ventilation to carbon dioxide output (V’E/V’CO2 slope) is the strongest death predictor before larger lung resections

The minute ventilation to CO2 production ratio (V’E/V’CO2 slope) was recently identified as a mortality predictor after lung surgery, but the effect of the resection extent was not taken into account.  The aim of this study was to investigate the role of V’E/V’CO2 slope as preoperative mortality predictor depending on the type of surgery performed. Retrospective analysis was performed on 263 consecutive patients evaluated before surgery for lung cancer. Death within 30 days and serious respiratory complications were considered. Univariate and multivariate regression analyses were used to identify independent predictors of death. Lobectomy or bilobectomy were performed in 186 patients with 29/186 (15.6%) serious pulmonary complications and 6/186 (3.2%) deaths. Pneumonectomy was performed in 77 patients with 14/77 (18.2%) serious complications and 5/77 (6.5%) deaths.  Considering the whole group, the peak oxygen consumption (V'02peak, L/ min; z=-2.66, p<0.008, OR 0.007) and V'E/V'C02 slope (z=2.80, p<0.005, OR 1.14) were independent predictors of mortality whereas in pneumonectomies V'E/V'C02 slope (z=2.34, p<0.02, OR 1.22) was the only independent predictor of mortality. High V’E/V’CO2 slope, age and low V'02peak are predictors of death and severe complications after lung surgery. Before larger resections as pneumonectomies an increased V’E/V’CO2 slope represents the best mortality predictor

Sentidos e indicios de vida de las prácticas religiosas urbanas de las mujeres laicas. Estudio de casos: parroquia santa maría de la paz y parroquia San Nicolás de Bari pastoral urbana, 2011-2012.

La investigación enfoca los sentidos e indicios de vida de las prácticas religiosas de las mujeres que asisten a dos parroquias de la ciudad: Santa María de la Paz, ubicada en los barrios del noroeste, y San Nicolás de Bari, emplazada en la zona periférica noreste de la Ciudad de Córdoba. A modo de hipótesis se plantea la emergencia de nuevos modos de vinculación y de pertenencia a la institución parroquial de los actores sociales laicos que concurren a las mismas, mayoritariamente mujeres con niveles de instrucción medio, que presumible-mente han modificado sus modos de vivir la fe y de practicar la religión a partir de las condiciones de transformación de la cultura urbana experimentada en la Ciudad en los últimos 20 años y que dan origen, a su vez, a nuevos sentidos de la religiosidad urbana y de la construcción de las subjetividades femeninas a partir de las nuevas referencias urbanas e identitarias. El objetivo principal pretende desarrollar un trabajo interdisciplinario de análisis e interpretación de los sentidos de las prácticas de espiritualidad de los crono-topos urbanos de los laicos, particularmente de las mujeres, que asisten a estas parroquias. Se espera obtener un exhaustivo conocimiento de la realidad urbana religiosa-cultural y de las prácticas espirituales de estas dos parroquias. La realización del proyecto de investigación supone un abordaje interdisciplinario bajo una metodología hermenéutica-cualitativa que implica dos momentos: empírico (sociológico: estudio de caso)y crítico hermenéutico (teológico y filosófico)

Clinical Outcomes in Breast Cancer: Innovations and Ideas Commentary on "Expression of CDK13 was Associated with Clinical Outcomes and Expression of HIF-1 and Beclin1 in Breast Cancer Patients"

The oncogenes underlying the development of breast cancer are not fully understood and careful and rigorous research is still necessary in this area. Before considering the role of these molecules ..

Role of Acute Graft-Versus-Host Disease in the Risk of Bacteremia and Invasive Fungal Disease after Allogeneic Hemopoietic Stem Cell Transplantation in Children. Results from a Single-Center Observational Study

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Osteogenic differentiation of MG63 cells in biodegradable scaffolds based on gelatin and genipin

Gelatin is a denatured collagen and commercially available as a biodegradable polymer. It has been extensively utilized for pharmaceutical and medical purposes, and its biosafety has been proven through long clinical applications. It showed an high cell attachment and proliferation, thus it has been widely considered as one of the best material to be used in medicine regenerative. Scaffolds based on pure gelatin showed a low mechanical and biological stability, so that a chemical crosslinking is necessary to improve its mechanical proprieties and success in clinical application. The aim of this study was to test the influence of a new porous composite scaffold based on gelatin/genipin composition on cell adhesion, proliferation and osteogenic potential. Genipin is a natural non toxic crosslinking agent which significantly improve the mechanical stability of the scaffold1. Osteoblast like cell (MG63) were seeded in collagen/genipin scaffolds for 24h, 7, 14, 21 and 28 days. Cell proliferation assay, light and electron microscopy analysis were performed to evaluate cell growth and morphological changes induced by cell/ scaffold interactions. Real Time PCR were carried out to evaluate the expression of the osteogenic markers such as collagen type I, osteonectin, osteopontin, ostecalcin and alkaline phosphatase proteins in MG63 seeded on gelatin/genipin scaffolds. Our results showed that gelatin/genipin scaffold is an excellent substrate for the growth and cell proliferation. Microscopy analysis showed an high cell adhesion on scaffold surface and an deep penetration in the macropores of the sponge. The Real Time data reveal a significant difference in the expression of the ostegenic markers in MG63 grown on gelatin/genipin scaffold compared to control samples. In conclusion, our data demonstrated that gelatin/genipin scaffold showed an high biocompatibility with human cells and an high osteogenic potential and it could be a potential tool in regenerative medicine

Novel understanding on genetic mechanisms of enteric neuropathies leading to severe gut dysmotility

The enteric nervous system (ENS) is the third division of the autonomic autonomic nervous system and the largest collection of neurons outside the central nervous system (CNS). The ENS has been referred to as "the brain in the gut" or "the second brain of the human body" because of its highly integrated neural circuits controlling a vast repertoire of gut functions, including absorption/secretion, splanchnic blood vessels, some immunological aspects, intestinal epithelial barrier, and gastrointestinal (GI) motility. The latter function is the result of the ENS fine-tuning over smooth musculature, along with the contribution of other key cells, such as enteric glia (astrocyte like cells supporting and contributing to neuronal activity), interstitial cells of Cajal (the pacemaker cells of the GI tract involved in neuromuscular transmission), and enteroendocrine cells (releasing bioactive substances, which affect gut physiology). Any noxa insult perturbing the ENS complexity may determine a neuropathy with variable degree of neuro-muscular dysfunction. In this review, we aim to cover the most recent update on genetic mechanisms leading to enteric neuropathies ranging from Hirschsprung's disease (characterized by lack of any enteric neurons in the gut wall) up to more generalized form of dysmotility such as chronic intestinal pseudo-obstruction (CIPO) with a significant reduction of enteric neurons. In this line, we will discuss the role of the RAD21 mutation, which we have demonstrated in a family whose affected members exhibited severe gut dysmotility. Other genes contributing to gut motility abnormalities will also be presented. In conclusion, the knowledge on the molecular mechanisms involved in enteric neuropathy may unveil strategies to better manage patients with neurogenic gut dysmotility and pave the way to targeted therapies