Two-Stage Liver Transplantation with Temporary Porto-Middle Hepatic Vein Shunt

Two-stage liver transplantation (LT) has been reported for cases of fulminant liver failure that can lead to toxic hepatic syndrome, or massive hemorrhages resulting in uncontrollable bleeding. Technically, the first stage of the procedure consists of a total hepatectomy with preservation of the recipient's inferior vena cava (IVC), followed by the creation of a temporary end-to-side porto-caval shunt (TPCS). The second stage consists of removing the TPCS and implanting a liver graft when one becomes available. We report a case of a two-stage total hepatectomy and LT in which a temporary end-to-end anastomosis between the portal vein and the middle hepatic vein (TPMHV) was performed as an alternative to the classic end-to-end TPCS. The creation of a TPMHV proved technically feasible and showed some advantages compared to the standard TPCS. In cases in which a two-stage LT with side-to-side caval reconstruction is utilized, TPMHV can be considered as a safe and effective alternative to standard TPCS

Surface roughness of glazed feldspar, alumina, and zirconia-based ceramics

The aim of this study was to compare the mean surface roughness (Ra) of feldspar-, alumina-, and zirconia-based ceramics, testing the hypothesis that the feldspathic ceramics have lower average surface roughness (Ra) than the ceramics used for infrastructure. Eight disk specimens (5mm in diameter; 2mm in thickness) of each ceramic material were fabricated according to the manufacturer's specifi cations: V7-feldspathic veneer ceramic (Vita VM7); VA-feldspathic veneer ceramic (Vitadur-α); IA-slip casted, glass-infi ltrated alumina-based ceramic (Vita In-Ceram Alumina); IZS-slip casted, glass-infi ltrated zirconia-reinforced alumina-based ceramic (Vita In-Ceram Zirconia); IZB-dry-pressed block ofglass-infi ltrated zirconia-reinforced alumina-based ceramic (Vita In-Ceram Zirconia 2000 for Cerec InLab). All materials were glazed as recommended by the manufacturer. Four Ra readings (Mitutoyo SJ 400) per specimen were performed, averaging the value per specimen (n=8). Ra values were statistically analyzed using one-way ANOVA and Tukey test (α=0.05). V7 showed the lowest mean Ra value (0.43±0.07 μm) compared to the other ceramics. There were no statistical differences between the mean Ra values of VA (0.94±0.2 μm), IA (0.7±0.13 μm), IZS (0.98±0.3 μm) and IZB (0.75±0.4 μm). The testing hypothesis was partially accepted. V7 showed a smoother ceramic surface than the VA. There were no statistically differences between the mean Ra value of the high crystalline content ceramics (IA, IZS, IZB)

Minimal Dark Matter predictions for galactic positrons, anti-protons, photons

We present the energy spectra of the fluxes of positrons, anti-protons and photons generated by Dark Matter annihilations in our galaxy, as univocally predicted by the model of Minimal Dark Matter. Due to multi-TeV masses and to the Sommerfeld enhancement of the annihilation cross section, distinctive signals are generated above the background, even with a modest astrophysical boost factor, in the range of energies soon to be explored by cosmic ray experiments.Comment: 16 pages, 6 figures, 3 tables of fit parameters. v3: in an addendum at page 17 we show that the Minimal Dark Matter prediction agrees with the anomaly in the positron spectrum announced by the PAMELA collaboratio

Physical activity in the prevention of peripheral artery disease in the elderly

Aging is a well-known cardiovascular risk factor and cardiovascular diseases (CVD) are estimated to be the most common cause of death in the elderly. Peripheral arterial disease (PAD) represents an important clinical manifestation of CVD leading to increase morbidity and mortality, especially in elderly population. The correct management of PAD population includes the prevention of cardiovascular events and relief of symptoms, most commonly intermittent claudication. Progressive physical activity is an effective treatment to improve walking distance and to reduce mortality and cardiovascular events in patients with PAD, however the ability to effectively engage in physical activity often declines with increasing age. The maintenance and increase of reserve functional capacity are important concepts in the elderly population. Ultimately, the goal in participation of physical activity in the healthy elderly population is maintenance and development of physical functional reserve capacity. Therefore, for individuals suffering of PAD, appropriate physical activity in the form of supervised exercise may serve as a primary therapy. Although there are few direct comparisons of therapeutic exercise programs vs. pharmacological or surgical interventions, these increases in walking distance are greater than those reported for the most widely used agents for claudication, pentoxyphylline, and cilostazol. Despite a reduction in mortality and improvement of quality of life caused by physical activity in the PAD population, the molecular, cellular, and functional changes that occur during physical activity are not completely understood. Therefore, this review article aims at presenting an overview of recent established clinical and molecular findings addressing the role of physical activity on PAD in the older population

Influence of Polymeric Restorative Materials on the Stress Distribution in Posterior Fixed Partial Dentures: 3D Finite Element Analysis

This study evaluated the effect of interim restorative materials (acrylic resin (AR), resin composite (RC) or polyetheretherketone (PEEK) for dental computer-aided design/computer-aided manufacturing (CAD/CAM)) on the stress distribution of a posterior three-unit fixed partial denture

Nanofibrous antibiotic‐eluting matrices: Biocompatibility studies in a rat model

This study evaluated the biocompatibility of degradable polydioxanone (PDS) electrospun drug delivery systems (hereafter referred as matrices) containing metronidazole (MET) or ciprofloxacin (CIP) after subcutaneous implantation in rats. Sixty adult male rats were randomized into six groups: SHAM (sham surgery); PDS (antibiotic‐free matrix); 1MET (one 25 wt% MET matrix); 1CIP (one 25 wt% CIP matrix); 2MET (two 25 wt% MET matrices); and 2CIP (two 25 wt% CIP matrices). At 3 and 30 days, animals were assessed for inflammatory cell response (ICR), collagen fibers degradation, and oxidative profile (reactive oxygen species [ROS]; lipid peroxidation [LP]; and protein carbonyl [PC]). At 3 days, percentages of no/discrete ICR were 100, 93.3, 86.7, 76.7, 50, and 66.6 for SHAM, PDS, 1MET, 1CIP, 2MET, and 2CIP, respectively. At 30 days, percentages of no/discrete ICR were 100% for SHAM, PDS, 1MET, and 1CIP and 93.3% for 2MET and 2CIP. Between 3 and 30 days, SHAM, 1CIP, and 2CIP produced collagen, while 1MET and 2MET were unchanged. At 30 days, the collagen fiber means percentages for SHAM, PDS, 1MET, 1CIP, 2MET, and 2CIP were 63.7, 60.7, 56.6, 62.6, 51.8, and 61.7, respectively. Antibiotic‐eluting matrices showed similar or better oxidative behavior when compared to PDS, except for CIP‐eluting matrices, which showed higher levels of PC compared to SHAM or PDS at 30 days. Collectively, our findings indicate that antibiotic‐eluting matrices may be an attractive biocompatible drug delivery system to fight periodontopathogens. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B, 2019.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152674/1/jbmb34389.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/152674/2/jbmb34389_am.pd