A interdisciplinaridade no ensino da arte

Anais do II Seminário Seminário Estadual PIBID do Paraná: tecendo saberes / organizado por Dulcyene Maria Ribeiro e Catarina Costa Fernandes — Foz do Iguaçu: Unioeste; Unila, 2014O presente trabalho tem por objetivo apresentar uma das propostas desenvolvidas no âmbito do Projeto PIBID Interdisciplinar Artes Cênicas e Música, discutindo o ensino da Arte no âmbito educacional. Para tanto, são levantados pontos relevantes do trabalho desenvolvido pelo Projeto no Colégio de Aplicação Pedagógica (CAP) vinculado à Universidade Estadual de Maringá (UEM) e analisados novos caminhos para contribuir para a aprendizagem da Arte dentro da escol

Tumores de pele não melanoma: estudo retrospectivo do perfil epidemiológico e desfecho a partir de margens comprometidas

Introdução: Os carcinomas de pele do tipo não melanoma são responsáveis por 30% dos tumores malignos no Brasil. O objetivo deste artigo foi avaliar o perfil epidemiológico e a conduta tomada a partir do diagnóstico histopatológico de margens comprometidas em pacientes com carcinomas de pele do tipo não melanoma tratados primariamente com cirurgia. Métodos: Estudo tipo coorte retrospectivo observacional. Os dados foram coletados de prontuário eletrônico de 1495 pacientes, apresentando 2457 carcinomas de pele do tipo não melanoma, operados entre janeiro de 2015 a dezembro de 2019. Resultados: Houve maior prevalência em homens (52,4%) e entre a sexta e a sétima décadas de vida (41,1%). O carcinoma basocelular foi o tipo histológico mais comum (75%). O risco de desenvolver carcinoma espinocelular foi 57,2% maior em pacientes com idade acima de 61 anos (risco relativo=1,572 (IC 95%: 1,316-1,878; p0,05). Conclusão: O estudo possibilitou melhor compreensão do perfil dos pacientes com carcinomas de pele do tipo não melanoma, bem como o percentual de margens comprometidas após excisão cirúrgica inicial e o tratamento realizado

Non-melanoma skin tumors: a retrospective study of the epidemiological profile and outcome from compromised margins

Introduction: Non-melanoma skin neoplasms are responsible for 30% of all malignant tumors in Brazil. The main objective of this article was to evaluate the epidemiological profile and the approach taken from the histopathological diagnosis of compromised margins in patients with non-melanoma skin neoplasms treated primarily with surgery. Methods: This is an observational retrospective cohort. Data were collected from electronic medical records of 1495 patients, resulting in 2457 non-melanoma skin neoplasms, from January 2015 to December 2019. Results: There was a higher prevalence in men (52.4%) and between the sixth and seventh decades of life (41.4%). Basal cell carcinoma was the most common histological type (75%). Those over the age of 61 are 57.2% more likely to develop basal cell carcinoma (relative risk=1,572 (95% CI: 1,316-1,878; p0.05). Conclusion: The study allowed a better understanding of the profile of patients with non-melanoma skin neoplasms and the percentage of compromised margins after initial surgical excision and the treatment performed

Evaluation of bioactive glass and platelet-rich plasma for bone healing in rabbit calvarial defects

Made available in DSpace on 2019-09-12T16:57:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2013Bone regeneration is an important objective in clinical dental practice and has been used for different applications. The aim of this study was to evaluate the effectiveness of platelet-rich plasma (PRP) and bioactive glass (BG) for bone healing of surgical calvarial defects in rabbits. Two 8-mm defects were prepared in the parietal bones of ten animals, and the animals were randomly assigned to two groups. In each group, two subgroups were created with five defects each: BC - blood clot, BG, PRP and PRP + BG. Thus, four treatments were performed with five specimens each. The animals were sacrificed after 12 weeks and the specimens were analyzed radiographically, histologically and histomorphometrically. Data were subjected to ANOVA and Tukey's tests (alpha = 0.05). Outcomes demonstrated that the PRP group had higher bone density (%) values than the groups not treated with PRP (P < 0.05). Histometrically, both groups treated with PRP (PRP: 25.6 +/- 9.9; PRP + BG: 25.8 +/- 12.4) demonstrated higher percentages of new bone formation than the groups not treated with PRP (BG: 6.1 +/- 4.3; BC: 7.8 +/- 5.6) (P < 0.05). The results suggested that PRP improved bone repair and that bioactive glass alone, or in association with PRP, did not improve bone healing.[Penteado, Luiz A. M.] Univ Fed Alagoas, Dept Dent, Maceio, AL, Brazil[Penteado, Luiz A. M.; Penteado, Roberta A. P. M.] Univ Ctr Maceio, Dept Dent, Maceio, AL, Brazil[Colombo, Carlos E. D.] Universidade de Taubaté (Unitau), Dept Dent, Sao Paulo, Brazil[Assis, Angelica O.; Gurgel, Bruno C. V.] Univ Fed Rio Grande do Norte, Dept Dent, BR-59056000 Natal, RN, Brazi

Antioxidant and antidepressant-like activities of semi-synthetic α-phenylseleno citronellal

AbstractIn this study, the antioxidant and antidepressant-like activities of the semi-synthetic compound α-phenylseleno citronellal (PhSeCIT) and the natural terpenoid R-citronellal (CIT) were evaluated. The biological potential of PhSeCIT and CIT was evaluated by antioxidant in vitro assays, such as 1,1-diphenyl-2-picryl-hydrazyl (DPPH), 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS), ferric ion reducing antioxidant power (FRAP) and linoleic acid oxidation. The compounds were also assessed by ex vivo tests to determine the acute toxicity, levels of thiobarbituric acid reactive species (TBARS), δ-aminolevulinate dehydratase (δ-Ala-D) and Na+/K+ ATPase activities. The antidepressant-like activity of compounds in the tail suspension test (TST) and forced swimming test (FST) was also investigated. The results demonstrated that the addition of an organoselenium group to (R)-citronellal increased its antioxidant properties, since PhSeCIT showed better activity than CIT. The treatment of mice with both compounds did not cause death of any animals. The levels of TBARS were significantly reduced by PhSeCIT in liver and cortex of animals, whereas CIT did not alter these parameters. In the TST and FST, PhSeCIT showed promising antidepressant-like activity, while CIT was not active in this test. Taken together, these data demonstrate the role of selenium in the antioxidant and antidepressant-like activities of (R)-citronellal

Extração assistida por banho ultrassônico de óleo de sementes de cupuaçu (Theobroma grandiflorum) utilizando etanol como solvente

A extração sólido-líquido é um dos processos mais eficientes na obtenção de óleos, principalmente em relação ao rendimento se comparada à prensagem a frio. Solventes verdes, como o etanol, apresentam-se como uma alternativa aos solventes orgânicos derivados do petróleo, já que sua origem é vegetal, oferecendo menores riscos ao meio ambiente e também à saúde humana, além de reduzir o custo do processo. Contudo, o etanol possui uma baixa afinidade química com a fração lipídica dos óleos, reduzindo o rendimento e aumentando o tempo de extração. Para avaliar o processo, foram realizadas extrações do óleo da semente de cupuaçu (Theobroma grandiflorum) em banho ultrassônico utilizando-se do planejamento experimental do tipo estrela, com as variáveis independentes de tempo e proporção solvente/amostra em massa e como variável dependente o teor de óleo obtido. O intervalo de tempo foi de 30 min a 90 min e a proporção solvente/amostra entre 3:1 e 5:1. Ao final deste trabalho, foi possível concluir que as variáveis analisadas impactam no rendimento da extração de forma linear e não possuem interdependência. Assim, construiu-se um modelo empírico para processo no intervalo de 95% de confiança com as variáveis codificadas

Oxygen tension affects histone remodeling of in vitro-produced embryos in a bovine model

In vitro production of bovine embryos is a biotechnology of great economic impact. Epigenetic processes, such as histone remodeling, control gene expression and are essential for proper embryo development. Given the importance of IVP as a reproductive biotechnology, the role of epigenetic processes during embryo development, and the important correlation between culture conditions and epigenetic patterns, the present study was designed as a 2 x 2 factorial to investigate the influence of varying oxygen tensions (O-2; 5% and 20%) and concentrations of fetal bovine serum (0% and 2.5%), during IVC, in the epigenetic remodeling of H3K9me2 (repressive) and H3K4me2 (permissive) in bovine embryos. Bovine oocytes were used for IVP of embryos, cleavage and blastocyst rates were evaluated, and expanded blastocysts were used for evaluation of the histone marks H3K9me2 and H3K4me2. Morulae and expanded blastocysts were also used to evaluate the expression of remodeling enzymes, specific to the aforementioned marks, by real-time polymerase chain reaction. Embryos produced in the presence of fetal bovine serum (2.5%) had a 10% higher rate of blastocyst formation. Global staining for the residues H3K9me2 and H3K4me2 was not affected significantly by the presence of serum. Notwithstanding, the main effect of oxygen tension was significant for both histone marks, with both repressive and permissive marks being higher in embryos cultured at the higher oxygen tension; however, expression of the remodeling enzymes did not differ in morulae or blastocysts in response to the varying oxygen tension. These results suggest that the use of serum during IVC of embryos increases blastocyst rate without affecting the evaluated histone marks and that oxygen tension has an important effect on the histone marks H3K9me2 and H3K4me2 in bovine blastocysts.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP