Letter from Ed. S[cribner\u27s] M[onthly] [Robert Underwood Johnson] to John Muir, 1878 Apr 24.

[letterhead: Editorial Rooms of Scribner’s Monthly, 743 Broadway, New York.] Apl. 24. 1878Mr John Muir, Dear Sir; We have read your “Douglass Squirrel” and have not been surprised to find it a desirable paper. We have marked it [underlined: accepted] and will pass it over to our Art Editor, Mr. Drake, for illustration. Your Lake sketch has just come to hand and will receive early attention. Condense your [Page 2]Farm Life observations some time (when you have taken the subject to heart) and let us see the result. Mrs Foote is now in the East but her familiarity with California [ scenery?] would enable her to make charming pictures out of the [illegible]dest sketches. It is not necessary to repeat that we hold your work in high regard. You know that we are Sincerely yours, Ed. [ S.M.?] 0078

Letter from Ed. S[cribner\u27s]M[onthly] [Robert Underwood Johnson] to John Muir, 1880 May 20.

[letterhead] May 20” 1880 Dear Mr. Muir: Your last letter to me has been displaced, but we have just recalled the [proposition?] you make of the articles on Alaska. We should very much like two and probably three papers on that subject to add to those we have on hand, in a definite announcement for next year. (The “California Alps Excursion” will appear in the forth coming July number). We want to[Page 2]begin these in November and go right on with them at only an interval of a month or so. We hope you will continue to give us the first chance at what you write, for unless there should be some [unlooked?] to prevent our handling the material, for cont[illegible], we should like to publish for you.With sincere regard, [Ed. S. M.?]0091

Letter from Eds. Scribner\u27s Monthly [Robert Underwood Johnson] to John Muir, 1877 Sep 28.

Editorial Rooms of Scribner’s Monthly, 743 Broadway, New York, Sept 28 1877.John Muir, Esq., Dear Sir: We suppose that Mr Drake has already men- tioned the contem- plated publication of your paper on the California bird in the January numb[illegible]. Meanwhile we be[illegible] that you will tell00753[Page 2]us whether you have in mind any other papers suitable for Scribner. In fact we should be glad to learn what are your enthusiasms and whether you have time to put them on paper. We have thought of a paper on Farm Life in California – the picturesque side of it – but do not know whether you would write spontaneously of the subject. As our best work is unsolicited, we hesitate about naming subjects, but trust that, if our [overtures?] are welcome to you, you will frankly write us, suggesting the topics that are nearest your heart. We are indeed[in margin: Most sincerely yours, Eds. Scribner’s Monthly

Heavy episodic drinking on college campuses: Does changing the legal drinking age make a difference

ABSTRACT. Objective: This article extends the compartmental model previously developed by Scribner et al. in the context of college drinking to a mathematical model of the consequences of lowering the legal drinking age. Method: Using data available from 32 U.S. campuses, the analyses separate underage and legal age drinking groups into an eight-compartment model with different alcohol availability (wetness) for the underage and legal age groups. The model evaluates the likelihood that underage students will incorrectly perceive normative drinking levels to be higher than they actually are (i.e., misperception) and adjust their drinking accordingly by varying the interaction between underage students in social and heavy episodic drinking compartments. Results: The results evaluate the total heavy episodic drinker population and its dependence on the difference in misperception, as well as its dependence on underage wetness, legal age wetness, and drinking age. Conclusions: Results suggest that an unrealistically extreme combination of high wetness and low enforcement would be needed for the policies related to lowering the drinking age to be effective. (J. Stud. Alcohol Drugs, 72

Sunitinib malate in the treatment of recurrent or persistent uterine leiomyosarcoma: A Gynecologic Oncology Group phase II study

New agents are needed for patients with metastatic uterine leiomyosarcoma who progress after treatment with doxorubicin or gemcitabine-docetaxel. Agents targeting tumor vasculature have potential for activity in leiomyosarcoma. We aimed to assess the activity of sunitinib in patients with recurrent uterine leiomyosarcoma who had received one or two prior therapies by determining the frequency of patients who survived progression-free for at least six months or who achieved objective tumor response. We also aimed to characterize the toxicity of sunitinib and to estimate time-to-progression

Coordination by Cdc42 of actin, contractility, and adhesion for melanoblast movement in mouse skin

YesThe individual molecular pathways downstream of Cdc42, Rac, and Rho GTPases are well documented, but we know surprisingly little about how these pathways are coordinated when cells move in a complex environment in vivo. In the developing embryo, melanoblasts originating from the neural crest must traverse the dermis to reach the epidermis of the skin and hair follicles. We previously established that Rac1 signals via Scar/WAVE and Arp2/3 to effect pseudopod extension and migration of melanoblasts in skin. Here we show that RhoA is redundant in the melanocyte lineage but that Cdc42 coordinates multiple motility systems independent of Rac1. Similar to Rac1 knockouts, Cdc42 null mice displayed a severe loss of pigmentation, and melanoblasts showed cell-cycle progression, migration, and cytokinesis defects. However, unlike Rac1 knockouts, Cdc42 null melanoblasts were elongated and displayed large, bulky pseudopods with dynamic actin bursts. Despite assuming an elongated shape usually associated with fast mesenchymal motility, Cdc42 knockout melanoblasts migrated slowly and inefficiently in the epidermis, with nearly static pseudopods. Although much of the basic actin machinery was intact, Cdc42 null cells lacked the ability to polarize their Golgi and coordinate motility systems for efficient movement. Loss of Cdc42 de-coupled three main systems: actin assembly via the formin FMNL2 and Arp2/3, active myosin-II localization, and integrin-based adhesion dynamics.Cancer Research UK (to L.M.M. [A17196], R.H.I. [A19257], and S.W.G.T.) and NIH grants P01-GM103723 and P41-EB002025 (to K.M.H.). N.R.P. is supported by a Pancreatic Cancer Research Fund grant (to L.M.M.). Funding to Prof. Rottner by the Deutsche Forschungsgemeinschaft (grant RO2414/3-2)