26 research outputs found
Strong structural effect of the position of a single acetylaminofluorene adduct within a mutation hot spot
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Mutagenicity of 7-iodo and 7-fluoro derivatives of N-hydroxy- and N-acetoxy-n-2-acetylaminoflourene in the Salmonella typbimurium assay
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Observing Translesion Synthesis of an Aromatic Amine DNA Adduct by a High-fidelity DNA Polymerase
No full textTrading Places: How Do DNA Polymerases Switch during Translesion DNA Synthesis?
No full textThe replicative bypass of base damage in DNA (translesion DNA synthesis [TLS]) is a ubiquitous mechanism for relieving arrested DNA replication. The process requires multiple polymerase switching events during which the high-fidelity DNA polymerase in the replication machinery arrested at the primer terminus is replaced by one or more polymerases that are specialized for TLS. When replicative bypass is fully completed, the primer terminus is once again occupied by high-fidelity polymerases in the replicative machinery. This review addresses recent advances in our understanding of DNA polymerase switching during TLS in bacteria such as E. coli and in lower and higher eukaryotes
Involvement of DnaE, the Second Replicative DNA Polymerase from Bacillus subtilis, in DNA Mutagenesis
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