Low-field magnetoresistance in granular Pb films near the insulator-superconductor transition

We have studied the insulator-superconductor transition in quench-condensed granular Pb films from 0.1 to 10 K. Resistance measurements were made in zero magnetic field and low noise conditions. Magnetoresistance measurements were also performed for low magnetic fields (less than 100 G). The magnetoresistance results on the superconducting side of the transition suggest that we are directly probing the finite length scales associated with the range of phase coherence in these granular materials

Crossover from phase fluctuation to amplitude-dominated superconductivity: A model system

We have experimentally studied a model system that demonstrates the crossover from a superconductor that is dominated by phase fluctuations, to one in which the amplitude of the order parameter is the controlling influence on Tc. This model system is comprised of two-dimensional granular Pb with an overlayer of Ag. The system displays many aspects of the phase diagram of the concentration dependence of Tc in the high-Tc superconductors, and this crossover has been applied to explain the phase diagram in that case. We point out the similarities and differences between the model system presented in this paper and the high-Tc superconductors

Tunneling into granular Pb films in the superconducting and insulating regimes

Tunneling measurements have been performed on both sides of the insulator-superconductor transition in quench-condensed granular Pb films. The results indicate that the Pb film consists of fully superconducting grains with essentially bulk values for the superconducting energy gap and transition temperature, even when the film exhibits insulating behavior in transport measurements. The density of states inferred from measurements in perpendicular magnetic field are consistent with magnetic spin-flip broadening

Scanning Josephson Tunneling Microscopy of Single Crystal Bi\u3csub\u3e2\u3c/sub\u3eSr\u3csub\u3e2\u3c/sub\u3eCaCu\u3csub\u3e2\u3c/sub\u3eO\u3csub\u3e8+δ\u3c/sub\u3e with a Conventional Superconducting Tip

We have performed both Josephson and quasiparticle tunneling in vacuum tunnel junctions formed between a conventional superconducting scanning tunneling microscope tip and overdoped Bi2Sr2CaCu2O8+δ single crystals. A Josephson current is observed with a peak centered at a small finite voltage due to the thermal-fluctuation-dominated superconducting phase dynamics. Josephson measurements at different surface locations yield local values for the Josephson IcRn product. Corresponding energy gap measurements were also performed and a surprising inverse correlation was observed between the local IcRn product and the local energy gap

Negative magnetoresistance, negative electroresistance, and metallic behavior on the insulating side of the two-dimensional superconductor-insulator transition in granular Pb films

Granular Pb thin films on the insulating side of the two-dimensional superconductor-insulator transition are observed to exhibit a large negative magnetoresistance and electroresistance change in resistance with electric field at low temperatures. At high measurement voltages and low temperatures, the film resistances become temperature independent creating a metallic state. These phenomena are explained as manifestations of transport due to intergranular quasiparticle tunneling. This explanation might also provide insights into the similar behavior observed in other superconductors

Perioperative donor bone marrow infusion augments chimerism in heart and lung transplant recipients

Background.: We and others have demonstrated that a low level of donor cell chimerism was present for years after transplantation in tissues and peripheral blood of heart and lung recipients; it was associated, in the latter, with a lower incidence of chronic rejection. To augment this phenomenon, we initiated a trial combining simultaneous infusion of donor bone marrow with heart or lung allotransplantation. Methods.: Between September 1993 and January 1995, 15 nonconditioned patients received either heart (n = 10) or lung (n = 5) allografts concurrently with an infusion of unmodified donor bone marrow (3.0 × 108 cells/kg), and were maintained on an immunosuppressive regimen consisting of tacrolimus and steroids. Results.: There was no complication associated with the infusion of donor bone marrow. Chimerism was detectable in 73% of bone marrow-augmented patients up to the last sample tested. Of the 5 control recipients who did not receive bone marrow infusion, only 1 had detectable chimerism by flow on postoperative day 15, which dwindled to an undetectable level by postoperative day 36. None of the patients had evidence of donor-specific immune modulation by mixed lymphocyte reaction. Conclusions.: The combined infusion of donor bone marrow and heart or lung transplantation, without preconditioning of the recipient, is safe and is associated with an augmentation of donor cell chimerism. © 1995 The Society of Thoracic Surgeons

Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding

Newly generated actin free barbed ends at the front of motile cells provide sites for actin filament assembly driving membrane protrusion. Growth factors induce a rapid biphasic increase in actin free barbed ends, and we found both phases absent in fibroblasts lacking H+ efflux by the Na-H exchanger NHE1. The first phase is restored by expression of mutant cofilin-H133A but not unphosphorylated cofilin-S3A. Constant pH molecular dynamics simulations and nuclear magnetic resonance (NMR) reveal pH-sensitive structural changes in the cofilin C-terminal filamentous actin binding site dependent on His133. However, cofilin-H133A retains pH-sensitive changes in NMR spectra and severing activity in vitro, which suggests that it has a more complex behavior in cells. Cofilin activity is inhibited by phosphoinositide binding, and we found that phosphoinositide binding is pH-dependent for wild-type cofilin, with decreased binding at a higher pH. In contrast, phosphoinositide binding by cofilin-H133A is attenuated and pH insensitive. These data suggest a molecular mechanism whereby cofilin acts as a pH sensor to mediate a pH-dependent actin filament dynamics

Incorporating temporal and spatial variability of salt-marsh foraminifera into sea-level reconstructions

Foraminifera from salt-marsh environments have been used extensively in quantitative relative sea-level reconstructions due to their strong relationship with tidal level. However, the influence of temporal and spatial variability of salt-marsh foraminifera on quantitative reconstructions remains unconstrained. Here, we conducted a monitoring study of foraminifera from four intertidal monitoring stations in New Jersey from high marsh environments over three years that included several extreme weather (temperature, precipitation, and storm surge) events. We sampled four replicates from each station seasonally (four times per year) for a total of 188 samples. The dead foraminiferal assemblages were separated into four site-specific assemblages. After accounting for systematic trends in changes in foraminifera over time among stations, the distribution of foraminiferal assemblages across monitoring stations explained ~87% of the remaining variation, while ~13% can be explained by temporal and/or spatial variability among the replicate samples. We applied a Bayesian transfer function to estimate the elevation of the four monitoring stations. All samples from each station predicted an elevation estimate within a 95% uncertainty interval consistent with the observed elevation of that station. Combining samples into replicate- and seasonal-aggregate datasets decreased elevation estimate uncertainty, with the greatest decrease in aggregate datasets from Fall and Winter. Information about the temporal and spatial variability of modern foraminiferal distributions was formally incorporated into the Bayesian transfer function through informative foraminifera variability priors and was applied to a Common Era relative sea-level record in New Jersey. The average difference in paleomarsh elevation estimates and uncertainties using an informative vs uninformative prior was minimal