435 research outputs found
LOFAR ser universum pÄ ett helt nytt sÀtt
Radioteleskopet LOFAR Àr störst i vÀrlden och först i sitt
slag. Med mÀngder av enkla antenner och en oerhört kraftfull
dator skapar det bilder av rymden pÄ ett helt nytt sÀtt
Total hospital stay for hip fracture: measuring the variations due to pre-fracture residence, rehabilitation, complications and comorbidities
SN 2003du: Signatures of the Circumstellar Environment in a Normal Type Ia Supernova?
We present observations of the Type Ia supernova 2003du and report the
detectionof an unusual, high-velocity component in the Ca II infrared triplet,
similar tofeatures previously observed in SN 2000cx and SN 2001el. This feature
exhibits a large expansion velocity (~18,000 km/s) which is nearly constant
between -7 and +2 days relative to maximum light, and disappears shortly
thereafter. Otherthan this feature, the spectral evolution and light curve
resemble those of a normal SN Ia.
We find that the Ca II feature can plausibly be caused by a dense shell
formed when circumstellar material of solar abundance is overrun by the rapidly
expanding outermost layers of the SN ejecta. Model calculations show that the
optical and infrared spectra are remarkably unaffected by the circumstellar
interaction. In particular, no hydrogen lines are detectable in either
absorption or emission. The only qualitatively different features are the
strong, high-velocity feature in the Ca II IR-triplet, and a somewhat weaker O
I feature near 7,300 AA. The morphology and time evolution of these features
provide an estimate for the amount of accumulated matter and an indication of
the mixing in the dense shell. We apply these diagnostic tools to SN 2003du and
infer that about 2 x 10^{-2} M_sun of solar abundance material may have
accumulated in a circumstellar shell prior to the observations. Furthermore,
the early light curve data imply that the circumstellar material was originally
very close to the progenitor system, perhaps from an accretion disk, Roche lobe
or common envelope.Comment: 35 Pages, 11 Figures, to appear in ApJ. Resubmission includes
expanded discussion & new figures to match with accepted journal versio
Community health volunteersâ capacity for hygiene behaviour change: evidence from urban Kenya
Community health volunteers (CHVs) play an important role in health service delivery and are increasingly involved in water, sanitation and hygiene (WASH) behaviour change promotion. However, the realities of CHVs work, engagement with the health sector, and daily challenges remain undocumented. This mixed-methods study explored CHVs capacity to deliver an infant hygiene intervention in an urban informal settlement in Kenya. Findings suggest that CHVs are overburdened, receive inconsistent training, and forced to compromise their commitments in order to sustain their own livelihood. Sustained efforts in appreciating the work of CHVs, sustained supplies for CHVs, operational training in communication behaviour change methods and notable efforts in breaking the vicious circle of poverty in informal settlements would go a long way in promoting healthy seeking behaviours
Concurrent and prospective associations among biological maturation, and physical activity at 11 and 13 years of age
This study examined concurrent and prospective associations between objective measures of biological maturation, body composition and physical activity (PA) in adolescent males (n=671) and females (n=680). Participants born to women recruited to the Avon Longitudinal Study of Parents and Children birth cohort study were assessed at 11 and 13 years. Percentage of predicted adult stature was used as an estimate of biological maturation. PA and time sedentary was assessed over 7 consecutive days using Actigraph accelerometers. Body composition was assessed using whole-body DXA scans. At 11 and 13 years, maturity in males was inversely associated with accelerometer counts-per-minute (CPM) and time engaged in light PA, and positively associated with time sedentary. In females, maturity was inversely associated with accelerometer (CPM) at 11 but not 13 years. Adjusting for accelerometer wear times and corresponding activity levels at 11 years, maturity and percentage fat mass at 11 years did not predict any indices of PA or sedentary behavior in males or females at 13 years. Whereas advanced maturation in males is associated with less PA and more sedentary behavior at 11 and 13 years, maturity at 11 does not predict PA or sedentary behavior at 13 years in either sex
Aerobic glycolysis is required for spatial memory acquisition but not memory retrieval in mice
The consolidation of newly formed memories and their retrieval are energetically demanding processes. Aerobic glycolysis (AG), also known as the Warburg effect, consists of the production of lactate from glucose in the presence of oxygen. The astrocyte neuron lactate shuttle hypothesis posits that astrocytes process glucose by AG to generate lactate, which is used as a fuel source within neurons to maintain synaptic activity. Studies in mice have demonstrated that lactate transport between astrocytes and neurons is required for long-term memory formation, yet the role of lactate production in memory acquisition and retrieval has not previously been explored. Here, we examined the effect of dichloroacetate (DCA), a chemical inhibitor of lactate production, on spatial learning and memory in mice using the Morris water maze (MWM). In vivo hyperpolarized 13 C-pyruvate magnetic resonance spectroscopy revealed decreased conversion of pyruvate to lactate in the mouse brain following DCA administration, concomitant with a reduction in the phosphorylation of pyruvate dehydrogenase. DCA exposure before each training session in the MWM impaired learning, which subsequently resulted in impaired memory during the probe trial. In contrast, mice that underwent training without DCA exposure, but received a single DCA injection before the probe trial exhibited normal memory. Our findings indicate that AG plays a key role during memory acquisition but is less important for the retrieval of established memories. Thus, the activation of AG may be important for learning-dependent synaptic plasticity rather than the activation of signaling cascades required for memory retrieval
High impactâ = âhigh statistical standards? Not necessarily so.
What are the statistical practices of articles published in journals with a high impact factor? Are there differences compared with articles published in journals with a somewhat lower impact factor that have adopted editorial policies to reduce the impact of limitations of Null Hypothesis Significance Testing? To investigate these questions, the current study analyzed all articles related to psychological, neuropsychological and medical issues, published in 2011 in four journals with high impact factors: Science, Nature, The New England Journal of Medicine and The Lancet, and three journals with relatively lower impact factors: Neuropsychology, Journal of Experimental Psychology-Applied and the American Journal of Public Health. Results show that Null Hypothesis Significance Testing without any use of confidence intervals, effect size, prospective power and model estimation, is the prevalent statistical practice used in articles published in Nature, 89%, followed by articles published in Science, 42%. By contrast, in all other journals, both with high and lower impact factors, most articles report confidence intervals and/or effect size measures. We interpreted these differences as consequences of the editorial policies adopted by the journal editors, which are probably the most effective means to improve the statistical practices in journals with high or low impact factors
Bio-Banding in Youth Sports::Background, Concept and Application
Inter-individual differences in size, maturity status, function, and behavior among youth of the same chronological age (CA) have long been a concern in grouping for sport. Bio-banding is a recent attempt to accommodate maturity-associated variation among youth in sport. The historical basis of the concept of maturity-matching and its relevance to youth sport, and bio-banding as currently applied are reviewed. Maturity matching in sport has often been noted but has not been systematically applied. Bio-banding is a recent iteration of maturity matching for grouping youth athletes into âbandsâ or groups based on characteristic(s) other than CA. The percentage of predicted young adult height at the time of observation is the estimate of maturity status of choice. Several applications of bio-banding in youth soccer have indicated positive responses from players and coaches. Bio-banding reduces, but does not eliminate, maturity-associated variation. The potential utility of bio-banding for appropriate training loads, injury prevention, and fitness assessment merits closer attention, specifically during the interval of pubertal growth. The currently used height prediction equation requires further evaluation
Physical activity and movement proficiency:the need for a biocultural approach
âGaps in Our Knowledgeâ are discussed in the context of the need to integrate biological and behavioral factors in a biocultural approach to physical activity and movement proficiency. Specific issues considered include outdoor play, organized and informal activity, biological maturation, tracking of activity, development of movement proficiency, and individual differences. Studies considered are largely based on youth in economically better-off, developed countries in the western culture context. There is a need to extend studies of physical activity and movement proficiency to different cultural contexts.</jats:p
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