Genome-edited zebrafish model of ABCC8 loss-of-function disease

ATP-sensitive potassium channel (

Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS

ABCC9-related intellectual disability and myopathy syndrome (AIMS) arises from loss-of-function (LoF) mutations in the ABCC9 gene, which encodes the SUR2 subunit of ATP-sensitive potassium (

Up All Night: The Shifting Roles of Home Media Formats as Transmedia Storytelling

In this age of convergence, where media platforms and industries are becoming increasingly connected and intertwined, ‘transmedia’ has become a buzzword that scholars and industry alike have come to perceive as the media production strategy of the future. When scholars theorise transmedia storytelling, they typically prioritise film, TV, videogames and websites. DVDs and Blu-Rays—physical formats that occupy a vital role in extending and repurposing media content across new terrains—are often overlooked. This chapter will question what specific roles they play in extending stories across media platforms. This chapter explores the specific case studies of Doctor Who and the Marvel Cinematic Universe

Expression of <i>kitlga</i> promotes differentiation of new melanocytes in the stump.

<p>A-A’. At the time of amputation and prior to induction of <i>kitlga</i>, melanocytes are well organized and form the proximal portion of the dorsal melanocyte stripe of the caudal fin (yellow trapezoid). B-B’. Following 7 days of <i>kitlga</i> expression, new melanocytes are visible both in the regenerate (brackets) as well as in the stump (grey arrowheads) in association with the dermal fibroblast clone. Red dashed lines indicate the amputation plane. Scale bar  =  250 mm.</p