Thermal barrier coatings for gas turbine and diesel engines

The present state of development of thin thermal barrier coatings for aircraft gas turbine engines and thick thermal barrier coatings for truck diesel engines is assessed. Although current thermal barrier coatings are flying in certain gas turbine engines, additional advances will be needed for future engines. Thick thermal barrier coatings for truck diesel engines have advanced to the point where they are being seriously considered for the next generation of engine. Since coatings for truck engines is a young field of inquiry, continued research and development efforts will be required to help bring this technology to commercialization

Some ground-state expectation values for the free parafermion Z(N) spin chain

We consider the calculation of ground-state expectation values for the non-Hermitian Z(N) spin chain described by free parafermions. For N=2 the model reduces to the quantum Ising chain in a transverse field with open boundary conditions. Use is made of the Hellmann-Feynman theorem to obtain exact results for particular single site and nearest-neighbour ground-state expectation values for general N which are valid for sites deep inside the chain. These results are tested numerically for N=3, along with how they change as a function of distance from the boundary.Comment: 17 pages, 4 figures; extra reference

Natural Enemies of Cranberry Fruitworm, \u3ci\u3eAcrobasis Vaccinii\u3c/i\u3e, (Lepidoptera: Pyraudae) in Michigan Highbush Blueberries

A two-year study was conducted in Michigan highbush blueberries to determine the complex of parasitoids attacking cranberry fruitworm, Acrobasis vaccinii. Eight parasitoid species and one fungal pathogen were collected. Parasitism of collected hosts ranged from 6.6% to 28.1%. The more common larval parasitoid encountered was Campoletis patsuiketorum (Hymenoptera: Ichneumonidae). The more common parasitoid recovered from fruitworm hibernacula was Villa lateralis (Diptera: Bombyliidae). This study documented six unreported natural enemies of cranberry fruitworm, including C. patsuiketorum; V. lateralis; Diadegma compressum (Hymenoptera: Ichneumonidae); Compsilura concinnata (Diptera: Tachinidae); Memorilla pyste (Diptera: Tachinidae); an undescribed Microtypus species (Hymenoptera: Braconidae); and a fungal pathogen, Paecilomyces near farinosus. This is the first known host association for the undescribed Microtypus species, and increases the known parasitoid complex of cranberry fruitworm to 17 species

Exceptional Points in the Baxter-Fendley Free Parafermion Model

Certain spin chains, such as the quantum Ising chain, have free fermion spectra which can be expressed as the sum of decoupled two-level fermionic systems. Free parafermions are a simple generalisation of this idea to $Z(N)$-symmetric clock models. In 1989 Baxter discovered a non-Hermitian but $PT$-symmetric model directly generalising the Ising chain, which was much later recognised by Fendley to be a free parafermion spectrum. By extending the model's magnetic field parameter to the complex plane, it is shown that a series of exceptional points emerges, where the quasienergies defining the free spectrum become degenerate. An analytic expression for the locations of these points is derived, and various numerical investigations are performed. These exceptional points also exist in the Ising chain with a complex transverse field. Although the model is not in general $PT$-symmetric at these exceptional points, their proximity can have a profound impact on the model on the $PT$-symmetric real line. Furthermore, in certain cases of the model an exceptional point may appear on the real line (with negative field).Comment: 17 pages, 6 figures, Figure 3 has been changed to use the convention that the quasienergies have arguments in the range (-pi/N, pi/N], + minor change

The present and future of serum diagnostic tests for testicular germ cell tumours

Testicular germ cell tumours (GCTs) are the most common malignancy occurring in young adult men and the incidence of these tumours is increasing. Current research priorities in this field include improving overall survival for patients classified as being 'poor-risk' and reducing late effects of treatment for patients classified as 'good-risk'. Testicular GCTs are broadly classified into seminomas and nonseminomatous GCTs (NSGCTs). The conventional serum protein tumour markers α-fetoprotein (AFP), human chorionic gonadotrophin (hCG) and lactate dehydrogenase (LDH) show some utility in the management of testicular malignant GCT. However, AFP and hCG display limited sensitivity and specificity, being indicative of yolk sac tumour (AFP) and choriocarcinoma or syncytiotrophoblast (hCG) subtypes. Furthermore, LDH is a very nonspecific biomarker. Consequently, seminomas and NSGCTs comprising a pure embryonal carcinoma subtype are generally negative for these conventional markers. As a result, novel universal biomarkers for testicular malignant GCTs are required. MicroRNAs are short, non-protein-coding RNAs that show much general promise as biomarkers. MicroRNAs from two 'clusters', miR-371–373 and miR-302–367, are overexpressed in all malignant GCTs, regardless of age (adult or paediatric), site (gonadal or extragonadal) and subtype (seminomas, yolk sac tumours or embryonal carcinomas). A panel of four circulating microRNAs from these two clusters (miR-371a-3p, miR-372-3p, miR-373-3p and miR-367-3p) is highly sensitive and specific for the diagnosis of malignant GCT, including seminoma and embryonal carcinoma. In the future, circulating microRNAs might be useful in diagnosis, disease monitoring and prognostication of malignant testicular GCTs, which might also reduce reliance on serial CT scanning. For translation into clinical practice, important practical considerations now need addressing.The authors would like to acknowledge grant funding from CwCUK/GOSHCC (M.J.M. N.C. grant W1058), SPARKS (M.J.M. N.C. grant 11CAM01), CRUK (N.C. grant A13080) MRC (M.J.M. grant MC_EX_G0800464) and National Health Service funding to the Royal Marsden/Institute of Cancer Research National Institute for Health Research Biomedical Research Centre for Cancer (R.A.H.). The authors also thank the Max Williamson Fund, the Josh Carrick Foundation and The Perse Preparatory School, Cambridge for support.This is the author accepted manuscript. The final version is available fromNature Publishing Group via https://doi.org/10.1038/nrurol.2016.17

Quantitative proteomics: the copy number of pyruvate dehydrogenase is more than 102-fold lower than that of complex III in human mitochondria

AbstractPyruvate dehydrogenase (PDH) and complex III are two key protein complexes in mitochondrial metabolic activity. Using a novel quantitative Western blotting method, we find that PDH and complex III exist at a steady-state ratio of 1:100, 1:128 and 1:202 in HeLa cell extracts, fibroblast mitochondria and heart tissue mitochondria, respectively. This difference in stoichiometry is reflected in the immunogold labeling intensities of the two complexes and by the much more sparse distribution of PDH in fluorescence microscopy. In Rho0 fibroblasts there is a 64% reduction of complex III but the concentration of PDH remains the same as wild-type

Comparison of Forward, Backward, and Conventional Training in the Learning of a List of CVC Trigrams

Ss were instructed to learn a list of 10 CVC trigrams by either the conventional serial anticipation method, backward conditioning or forward conditioning. The F ratio failed to show a significant difference between the three experimental groups. The results contradict previous results which shown that forward training is more efficient than the other two methods