318 research outputs found

    Remote Monitor Alarm System

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    A remote monitor alarm system monitors discrete alarm and analog power supply voltage conditions at remotely located communications terminal equipment. A central monitoring unit (CMU) is connected via serial data links to each of a plurality of remote terminal units (RTUS) that monitor the alarm and power supply conditions of the remote terminal equipment. Each RTU can monitor and store condition information of both discrete alarm points and analog power supply voltage points in its associated communications terminal equipment. The stored alarm information is periodically transmitted to the CMU in response to sequential polling of the RTUS. The number of monitored alarm inputs and permissible voltage ranges for the analog inputs can be remotely configured at the CMU and downloaded into programmable memory at each RTU. The CMU includes a video display, a hard disk memory, a line printer and an audio alarm for communicating and storing the alarm information received from each RTU

    Metabolic regulation of APOBEC-1 Complementation Factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes

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    AbstractAPOBEC-1 Complementation Factor (ACF) is an RNA-binding protein that interacts with apoB mRNA to support RNA editing. ACF traffics between the cytoplasm and nucleus. It is retained in the nucleus in response to elevated serum insulin levels where it supports enhanced apoB mRNA editing. In this report we tested whether ACF may have the ability to regulate nuclear export of apoB mRNA to the sites of translation in the cytoplasm. Using mouse models of obesity-induced insulin resistance and primary hepatocyte cultures we demonstrated that both nuclear retention of ACF and apoB mRNA editing were reduced in the livers of hyperinsulinemic obese mice relative to lean controls. Coincident with an increase in the recovery of ACF in the cytoplasm was an increase in the proportion of total cellular apoB mRNA recovered in cytoplasmic extracts. Cytoplasmic ACF from both lean controls and obese mouse livers was enriched in endosomal fractions associated with apoB mRNA translation and ApoB lipoprotein assembly. Inhibition of ACF export to the cytoplasm resulted in nuclear retention of apoB mRNA and reduced both intracellular and secreted ApoB protein in primary hepatocytes. The importance of ACF for modulating ApoB was supported by the finding that RNAi knockdown of ACF reduced ApoB secretion. An additional discovery from this study was the finding that leptin is a suppressor ACF expression. Dyslipidemia is a common pathology associated with insulin resistance that is in part due to the loss of insulin controlled secretion of lipid in ApoB-containing very low density lipoproteins. The data from animal models suggested that loss of insulin regulated ACF trafficking and leptin regulated ACF expression may make an early contribution to the overall pathology associated with very low density lipoprotein secretion from the liver in obese individuals

    On the topology of stationary black holes

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    We prove that the domain of outer communication of a stationary, globally hyperbolic spacetime satisfying the null energy condition must be simply connected. Under suitable additional hypotheses, this implies, in particular, that each connected component of a cross-section of the event horizon of a stationary black hole must have spherical topology.Comment: 7 pages, Late

    Large capacity oblique all-wing transport aircraft

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    Dr. R. T. Jones first developed the theory for oblique wing aircraft in 1952, and in subsequent years numerous analytical and experimental projects conducted at NASA Ames and elsewhere have established that the Jones' oblique wing theory is correct. Until the late 1980's all proposed oblique wing configurations were wing/body aircraft with the wing mounted on a pivot. With the emerging requirement for commercial transports with very large payloads, 450-800 passengers, Jones proposed a supersonic oblique flying wing in 1988. For such an aircraft all payload, fuel, and systems are carried within the wing, and the wing is designed with a variable sweep to maintain a fixed subsonic normal Mach number. Engines and vertical tails are mounted on pivots supported from the primary structure of the wing. The oblique flying wing transport has come to be known as the Oblique All-Wing (OAW) transport. This presentation gives the highlights of the OAW project that was to study the total concept of the OAW as a commercial transport

    Theorems on gravitational time delay and related issues

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    Two theorems related to gravitational time delay are proven. Both theorems apply to spacetimes satisfying the null energy condition and the null generic condition. The first theorem states that if the spacetime is null geodesically complete, then given any compact set KK, there exists another compact set KK' such that for any p,q∉Kp,q \not\in K', if there exists a ``fastest null geodesic'', γ\gamma, between pp and qq, then γ\gamma cannot enter KK. As an application of this theorem, we show that if, in addition, the spacetime is globally hyperbolic with a compact Cauchy surface, then any observer at sufficiently late times cannot have a particle horizon. The second theorem states that if a timelike conformal boundary can be attached to the spacetime such that the spacetime with boundary satisfies strong causality as well as a compactness condition, then any ``fastest null geodesic'' connecting two points on the boundary must lie entirely within the boundary. It follows from this theorem that generic perturbations of anti-de Sitter spacetime always produce a time delay relative to anti-de Sitter spacetime itself.Comment: 15 pages, 1 figure. Example of gauge perturbation changed/corrected. Two footnotes added and one footnote remove

    Solitons in Five Dimensional Minimal Supergravity: Local Charge, Exotic Ergoregions, and Violations of the BPS Bound

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    We describe a number of striking features of a class of smooth solitons in gauged and ungauged minimal supergravity in five dimensions. The solitons are globally asymptotically flat or asymptotically AdS without any Kaluza-Klein directions but contain a minimal sphere formed when a cycle pinches off in the interior of the spacetime. The solutions carry a local magnetic charge and many have rather unusual ergosurfaces. Perhaps most strikingly, many of the solitons have more electric charge or, in the asymptotically AdS case, more electric charge and angular momentum than is allowed by the usual BPS bound. We comment on, but do not resolve, the new puzzle this raises for AdS/CFT.Comment: 60 pages, 12 figures, 3 table

    Taking Blockchain Seriously

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    In the present techno-political moment it is clear that ignoring or dismissing the hype surrounding blockchain is unwise, and certainly for regulatory authorities and governments who must keep a grip on the technology and those promoting it, in order to ensure democratic accountability and regulatory legitimacy within the blockchain ecosystem and beyond. Blockchain is telling (and showing) us something very important about the evolution of capital and neoliberal economic reason, and the likely impact in the near future on forms and patterns of work, social organization, and, crucially, on communities and individuals who lack influence over the technologies and data that increasingly shape and control their lives. In this short essay I introduce some of the problems in the regulation of blockchain and offer counter-narratives aimed at cutting through the hype fuelling the ascendency of this most contemporary of technologies
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