Imaging in-stent restenosis: an inexpensive, reliable, and rapid preclinical model.

Preclinical models of restenosis are essential to unravel the pathophysiological processes that lead to in-stent restenosis and to optimize existing and future drug-eluting stents. A variety of antibodies and transgenic and knockout strains are available in rats. Consequently, a model for in-stent restenosis in the rat would be convenient for pathobiological and pathophysiological studies. In this video, we present the full procedure and pit-falls of a rat stent model suitable for high throughput stent research. We will show the surgical procedure of stent deployment, and the assessment of in-stent restenosis using the most elegant technique of OCT (Optical Coherence Tomography). This technique provides high accuracy in assessing plaque CSAs (cross section areas) and correlates well with histological sections, which require special and time consuming embedding and sectioning techniques. OCT imaging further allows longitudinal monitoring of the development of in-stent restenosis within the same animal compared to one-time snapshots using histology

Ethical implications of heart transplantation in elderly patients

AbstractJ Thorac Cardiovasc Surg 2001;121:434-

TASTE-AVERSION LEARNING AND ITS IMPLICATIONS FOR RODENT CONTROL

Although bait shyness has long been recognized as a problem to be overcome in the control of vertebrate pests, it has recently been suggested that the phenomenon might be turned to an advantage and used as an alternative, non-lethal form of control. Unfortunately, this technique has not proven to be as useful as hoped, as the work which has been done on coyotes is inconclusive at best and some recent work on rodents has cast serious doubts upon the method\u27s potential. However, an extensive literature dealing with the formation of poison-based food aversions now exists, and insights gained from these studies can be used to increase the efficacy of traditional, lethal control techniques. For example, the efficacy of pre-baiting may be greatly increased if the pre-bait is treated with a non-toxic flavor which mimics the flavor of the subsequently used toxin, even if this non-toxic flavor decreases the acceptability of the pre-bait

TASTE-AVERSION LEARNING AND ITS IMPLICATIONS FOR RODENT CONTROL

Although bait shyness has long been recognized as a problem to be overcome in the control of vertebrate pests, it has recently been suggested that the phenomenon might be turned to an advantage and used as an alternative, non-lethal form of control. Unfortunately, this technique has not proven to be as useful as hoped, as the work which has been done on coyotes is inconclusive at best and some recent work on rodents has cast serious doubts upon the method\u27s potential. However, an extensive literature dealing with the formation of poison-based food aversions now exists, and insights gained from these studies can be used to increase the efficacy of traditional, lethal control techniques. For example, the efficacy of pre-baiting may be greatly increased if the pre-bait is treated with a non-toxic flavor which mimics the flavor of the subsequently used toxin, even if this non-toxic flavor decreases the acceptability of the pre-bait

History and Logic Model NASA Goddard Space Flight Center Instrument Project Division (IPD) Schedule and Cost Study

No abstract availabl