European Paediatric Formulation Initiative (EuPFI)-Formulating Ideas for Better Medicines for Children.

© American Association of Pharmaceutical Scientists 2016, published by Springer US, available online at doi: https://doi.org/10.1208/s12249-016-0584-1The European Paediatric Formulation Initiative (EuPFI), founded in 2007, aims to promote and facilitate the preparation of better and safe medicines for children through linking research and information dissemination. It brings together the capabilities of the industry, academics, hospitals, and regulators within a common platform in order to scope the solid understanding of the major issues, which will underpin the progress towards the future of paediatric medicines we want.The EuPFI was formed in parallel to the adoption of regulations within the EU and USA and has served as a community that drives research and dissemination through publications and the organisation of annual conferences. The membership and reach of this group have grown since its inception in 2007 and continue to develop and evolve to meet the continuing needs and ambitions of research into and development of age appropriate medicines. Five diverse workstreams (age-appropriate medicines, Biopharmaceutics, Administration Devices, Excipients and Taste Assessment & Taste Masking (TATM)) direct specific workpackages on behalf of the EuPFI. Furthermore, EuPFI interacts with multiple diverse professional groups across the globe to ensure efficient working in the area of paediatric medicines. Strong commitment and active involvement of all EuPFI stakeholders have proved to be vital to effectively address knowledge gaps related to paediatric medicines, discuss potential areas for further research and identify issues that need more attention and analysis in the future.Peer reviewedFinal Accepted Versio

A cautionary note on the use of Ornstein Uhlenbeck models in macroevolutionary studies

Phylogenetic comparative methods are increasingly used to give new insights into the dynamics of trait evolution in deep time. For continuous traits the core of these methods is a suite of models that attempt to capture evolutionary patterns by extending the Brownian constant variance model. However, the properties of these models are often poorly understood, which can lead to the misinterpretation of results. Here we focus on one of these models – the Ornstein Uhlenbeck (OU) model. We show that the OU model is frequently incorrectly favoured over simpler models when using Likelihood ratio tests, and that many studies fitting this model use datasets that are small and prone to this problem. We also show that very small amounts of error in datasets can have profound effects on the inferences derived from OU models. Our results suggest that simulating fitted models and comparing with empirical results is critical when fitting OU and other extensions of the Brownian model. We conclude by making recommendations for best practice in fitting OU models in phylogenetic comparative analyses, and for interpreting the parameters of the OU model

T1X1.3/95-079 CONTRIBUTION TO T1 STANDARDS PROJECT

This contribution presents results of simulation of jitter generated by an ATM network transporting a DS3 signal, with clock recovery performed by an adaptive clock technique. ************************************************************************************** NOTICE This document has been prepared to assist the Standard Committee T1-Telecommunications. It is offered to the Committee as a basis for discussion and is not a binding proposal on AT&T Communications or AT&T. The requirements presented in this document are subject to change in form and numerical value after more study. AT&T Communications specifically reserves the right to add to, or amend, the statements contained herein. T1X1.3/95-079 1. Introduction This contribution presents an analysis of DS3 jitter generated by an ATM network that uses an adaptive clock frequency recovery technique. The adaptive clock technique is used to recover timing of a Continuous Bit Rate (CBR) signal that is converted to cells as it enters ..

Friends of the Sherlock Holmes Collections Newsletter, 2019, Vol 23, No. 3

Quarterly newsletter of the Friends of the Sherlock Holmes Collections at the University of Minnesota Libraries. This issue includes articles on the triennial conference, "Dark Places, Wicked Companions, and Strange Experiences," held at the University on August 8-11, 2019, the companion exhibition in the Elmer L. Andersen Library, an update from the curator, and regular columns from the Friends president and newsletter editor