THE ELEPHANT SHOOTING: COLONIAL LAW AND INDIRECT RULE IN KAOKO, NORTHWESTERN NAMIBIA, IN THE 1920s AND 1930s

The law as a means of sociopolitical control in colonial states has gained significance as an issue in the recent historiography of Africa. This article discusses the making of a criminal case in colonial Kaoko, northwestern Namibia in the 1920s and 30s. It focuses on the problem of African voice and narrative and the ways in which they have been transformed into written evidence in the course of legal investigation. It demonstrates that the archival documents which emerged from this case require careful methodological scrutiny if they are to be used for the reconstruction of the region's past. It goes beyond colonial law as constituting a particular discourse to conceive colonial law as a space for intervention and agency for both colonized and colonizers. The central argument raised in the article is that while the South African administration in northwestern Namibia allegedly aimed at prosecuting culprits and securing evidence for their transgressions, men and women in Kaoko used colonial law as an arena for the negotiation of social and political issues. Concerned with the case's impact on the configuration of gender, the article shows how colonial law became both a site of male representation and power, and a space for female contestation of male claims to sociopolitical master

Recursos tributarios en el orden nacional

El sistema impositivo argentino, como cualquier otro, tiene como función la aplicación de tributos. Los contribuyentes y responsables de dicho sistema muchas veces se sienten perjudicados por sufrir liquidaciones impositivas por parte de los organismos recaudadores nacionales que consideran excesivas y alejadas de la realidad, violando los principios de equidad y razonabilidad en el funcionamiento del sistema tributario nacional. En esta situación, la legislación tributaria prevé remedios o medios de impugnación que posibilitan la revisión en instancias posteriores del pronunciamiento del órgano jurisdiccional, y que se denominan recursos tributarios. El objetivo del presente trabajo de investigación es describir de la manera más sencilla y clara, todo lo referido a la rama recursiva del derecho tributario nacional. Se realizó con la premisa de que resultara una guía práctica y de utilidad para todos aquellos interesados en conocer sobre la materia recursiva - impositiva, así como también para los Contadores Públicos Nacionales en lo que se refiere a su actuación profesional en dicha rama.Fil: Laporte, Carina Ruth. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.Fil: Parada Rizzo, Lorena. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.Fil: Nuñez, María Laura. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas

Trace Metals do not Accumulate over Time in The Edible Mediterranean Jellyfish Rhizostoma pulmo (Cnidaria, Scyphozoa) from Urban Coastal Waters

Jellyfish as food represent a millennial tradition in Asia. Recently, jellyfish have also been proposed as a valuable source of protein in Western countries. To identify health risks associated with the potential human consumption of jellyfish as food, trace element accumulation was assessed in the gonads and umbrella tissues of the Mediterranean Rhizostoma pulmo (Macri, 1778), sampled over a period of 16 months along the shallow coastal waters a short distance from the city of Taranto, an area affected by metallurgic and oil refinery sources of pollution. Higher tissue concentrations of trace elements were usually detected in gonads than in umbrella tissue. In particular, significant differences in the toxic metalloid As, and in the metals Mn, Mo, and Zn, were observed among different tissues. The concentrations of vanadium were slightly higher in umbrella tissues than in gonads. No positive correlation was observed between element concentration and jellyfish size, suggesting the lack of bioaccumulation processes. Moreover, toxic element concentrations in R. pulmo were found below the threshold levels for human consumption allowed by Australian, USA, and EU Food Regulations. These results corroborate the hypothesis that R. pulmo is a safe, potentially novel food source, even when jellyfish are harvested from coastal areas affected by anthropogenic impacts

Looking for the best immune-checkpoint inhibitor in pre-treated NSCLC patients: An indirect comparison between nivolumab, pembrolizumab and atezolizumab

Immune-checkpoint inhibitors represent the new standard of care in patients with advanced NSCLC who progressed after first-line treatment. This work aim to assess any difference in both efficacy and safety profiles among Nivolumab, Pembrolizumab and Atezolizumab in pre-treated NSCLC patients. Randomized clinical trials comparing immune-checkpoint inhibitor versus docetaxel in pre-treated patients with advanced NSCLC were included and direct comparison meta-analysis of selected trials have been performed. Subsequently the summary estimates of Nivolumab, Pembrolizumab and Atezolizumab emerging from the direct meta-analysis were selected to provide the pooled estimates of hazard ratio (HR) and relative risk (RR) for the indirect comparisons among these agents. A total of 5 studies met the selection criteria and were included in the meta-analysis. Indirect comparisons for efficacy outcomes showed the RR for ORR nivolumab versus atezolizumab 1.66 (95% CI 1.07â2.58), pembrolizumab versus atezolizumab 1.94 (95% CI 1.30â2.90). No significant differences in both PFS and OS have been observed. Indirect comparisons for safety showed the RR for G3-5 AEs nivolumab versus pembrolizumab 0.41 (95% CI 0.29â0.60), nivolumab versus atezolizumab 0.50 (95% CI 0.35â0.72). No significant differences in both pneumonitis and discontinuation rate have been observed. The results of this work revealed that nivolumab and pembrolizumab are associated with a significant increase of ORR as compared to atezolizumab and nivolumab is associated with a significant lower incidence of G3-5 AEs as compared to the other drugs. These evidences could support the oncologists to select the best drug for each patient

Space Flight Effects on Antioxidant Molecules in Dry Tardigrades: The TARDIKISS Experiment

The TARDIKISS (Tardigrades in Space) experiment was part of the Biokon in Space (BIOKIS) payload, a set of multidisciplinary experiments performed during the DAMA (Dark Matter) mission organized by Italian Space Agency and Italian Air Force in 2011. This mission supported the execution of experiments in short duration (16 days) taking the advantage of the microgravity environment on board of the Space Shuttle Endeavour (its last mission STS-134) docked to the International Space Station. TARDIKISS was composed of three sample sets: one flight sample and two ground control samples. These samples provided the biological material used to test as space stressors, including microgravity, affected animal survivability, life cycle, DNA integrity, and pathways of molecules working as antioxidants. In this paper we compared the molecular pathways of some antioxidant molecules, thiobarbituric acid reactive substances, and fatty acid composition between flight and control samples in two tardigrade species, namely, Paramacrobiotus richtersi and Ramazzottius oberhaeuseri. In both species, the activities of ROS scavenging enzymes, the total content of glutathione, and the fatty acids composition between flight and control samples showed few significant differences. TARDIKISS experiment, together with a previous space experiment (TARSE), further confirms that both desiccated and hydrated tardigrades represent useful animal tool for space research

The Microbial Community Associated with Rhizostoma pulmo: Ecological Significance and Potential Consequences for Marine Organisms and Human Health

Jellyfish blooms are frequent and widespread in coastal areas worldwide, often associated with significant ecological and socio-economic consequences. Recent studies have also suggested cnidarian jellyfish may act as vectors of bacterial pathogens. The scyphomedusa Rhizostoma pulmo is an outbreak-forming jellyfish widely occurring across the Mediterranean basin. Using combination of culture-based approaches and a high-throughput amplicon sequencing (HTS), and based on available knowledge on a warm-affinity jellyfish-associated microbiome, we compared the microbial community associated with R. pulmo adult jellyfish in the Gulf of Taranto (Ionian Sea) between summer (July 2016) and winter (February 2017) sampling periods. The jellyfish-associated microbiota was investigated in three distinct compartments, namely umbrella, oral arms, and mucus secretion. Actinobacteria, Bacteroidetes, Chlamydiae, Cyanobacteria, Deinococcus-Thermus, Firmicutes, Fusobacteria, Planctomycetes, Proteobacteria, Rhodothermaeota, Spirochaetes, Tenericutes, and Thaumarchaeota were the phyla isolated from all the three R. pulmo compartments in the sampling times. In particular, the main genera Mycoplasma and Spiroplasma, belonging to the class Mollicutes (phylum Tenericutes), have been identified in all the three jellyfish compartments. The taxonomic microbial data were coupled with metabolic profiles resulting from the utilization of 31 different carbon sources by the BIOLOG Eco-Plate system. Microorganisms associated with mucus are characterized by great diversity. The counts of culturable heterotrophic bacteria and potential metabolic activities are also remarkable. Results are discussed in terms of R. pulmo ecology, the potential health hazard for marine and human life as well as the potential biotechnological applications related to the associated microbiome

Antioxidant Response during the Kinetics of Anhydrobiosis in Two Eutardigrade Species

Anhydrobiosis, a peculiar adaptive strategy existing in nature, is a reversible capability of organisms to tolerate a severe loss of their body water when their surrounding habitat is drying out. In the anhydrobiotic state, an organism lacks all dynamic features of living beings since an ongoing metabolism is absent. The depletion of water in the anhydrobiotic state increases the ionic concentration and the production of reactive oxygen species (ROS). An imbalance between the increased production of ROS and the limited action of antioxidant defences is a source of biomolecular damage and can lead to oxidative stress. The deleterious effects of oxidative stress were demonstrated in anhydrobiotic unicellular and multicellular organisms, which counteract the effects using efficient antioxidant machinery, mainly represented by ROS scavenger enzymes. To gain insights into the dynamics of antioxidant patterns during the kinetics of the anhydrobiosis of two tardigrade species, Paramacrobiotus spatialis and Acutuncus antarcticus, we investigated the activity of enzymatic antioxidants (catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase) and the amount of non-enzymatic antioxidants (glutathione) in the course of rehydration. In P. spatialis, the activity of catalase increases during dehydration and decreases during rehydration, whereas in A. antarcticus, the activity of superoxide dismutase decreases during desiccation and increases during rehydration. Genomic varieties, different habitats and geographical regions, different diets, and diverse evolutionary lineages may have led to the specialization of antioxidant strategies in the two specie

Mucosal Immunoregulatory Properties of Tsukamurella inchonensis to Reverse Experimental Food Allergy

The intestinal mucosa is lined by epithelial cells, which are key cells to sustain gut homeostasis. Food allergy is an immune-mediated adverse reaction to food, likely due to defective regulatory circuits. Tsukamurella inchonensis is a non-pathogenic bacterium with immunomodulatory properties. We hypothesize that the anti-inflammatory effect of dead T. inchonensis on activated epithelial cells modulates milk allergy through the restoration of tolerance in a mouse model. Epithelial cells (Caco-2 and enterocytes from mouse gut) and macrophages were stimulated with T. inchonensis and induction of luciferase under the NF-κB promoter, ROS and cytokines production were studied. Balb/c mice were mucosally sensitized with cow´s milk proteins plus cholera toxin and orally challenged with the allergen to evidence hypersensitivity symptoms. After that, mice were orally administered with heat-killed T. inchonensis as treatment and then challenged with the allergen. The therapeutic efficacy was in vivo (clinical score and cutaneous test) and in vitro (serum specific antibodies and cytokines-ELISA, and cell analysis-flow cytometry) evaluated. Heat-killed T. inchonensis modulated the induction of pro-inflammatory chemokines, with an increase in anti-inflammatory cytokines by intestinal epithelial cells and by macrophages with decreased OX40L expression. In vivo, oral administration of T. inchonensis increased the frequency of lamina propria CD4+CD25+FoxP3+ T cells, and clinical signs were lower in T. inchonensis-treated mice compared with milk-sensitized animals. In vivo depletion of Tregs (anti-CD25) abrogated T. inchonensis immunomodulation. In conclusion, these bacteria suppressed the intestinal inflammatory immune response to reverse food allergy.Fil: Smaldini, Paola Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; ArgentinaFil: Trejo, Fernando Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; ArgentinaFil: Rizzo, Gaston Pascual. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; ArgentinaFil: Comerci, Diego José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Kampinga, Jaap. Actinopharma Ltd.; Reino UnidoFil: Docena, Guillermo H.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentin

Evaluation of compost of swine waste as amendment for production of cut wallflowers (Matthiolaincana)

The intensification of swine production systems generates accumulation of manure, which if not stabilized can generate negative impact on the environment. At the same time, the demand for organic materials to amend the soil for the production of cut flowers has increased. The objective of the work was to evaluate the use of swine compost as an amendment in different proportions through the growth of wallflowers (Matthiolaincana). The trial consisted of four treatments with three repetitions each: T1: 15l/m2 , T2: 30l/m2 , T3: 60 l/m2 and T4: no incorporation of compost. A 12m x 1m flowerbed was used, divided into 12 experimental units. Phosphorus (P), calcium (Ca), magnesium (Mg), potassium (K), nitrates (NO3 - ), pH and electrical conductivity (EC) in a ratio of 1 / 5 (v/v sample / water), and organic matter (OM) were analyzed for each treatment. In addition compost quality and the presence of Escherichia coli and Salmonella spp. were also analyzed. The carbon / nitrogen (C / N) ratio of the compost was 14.1 and the respirometric index (IRE) of 0.55 mg O2 g -1 MO h-1 According to the TMECC (2001)[1], these values establish that the compost was stable and mature, on the other hand, the absence of pathogens E. coli and Salmonella ssp. was verified. The high electrical conductivity (CE) (5.53 dS.m-1 ) and the high concentration of sodium (11464 mg/l) in the compost were limiting for the development of wallflower (wallflower plant). The amendment with doses superior to 30 l/m 2 , caused a reduction of the growth and consequently lower quality of the floral stick. The evaluated swine compost is viable as an amendment to produce cut wallflowers up to 15l/m2.Inst. de Microbiología y Zoología Agrícola IMyZAFil: Riera, Nicolas Iván. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Microbiología y Zoología Agrícola; ArgentinaFil: Barbaro, Lorena Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Floricultura; ArgentinaFil: Karlanian, Monica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Floricultura; ArgentinaFil: Beily, Marí­a Eugenia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Microbiología y Zoología Agrícola; ArgentinaFil: Rizzo, Pedro Federico. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Microbiología y Zoología Agrícola; ArgentinaFil: Crespo, Diana Elvira. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Microbiología y Zoología Agrícola; ArgentinaFil: Giuffré, Lidia. Universidad de Buenos Aires. Facultad de Agronomía, Departamento de Recursos Naturales, Medio Ambiente. Cátedra de Edafología; Argentin

Caracterización de diferentes compost para su uso como componente de sustratos

Actualmente el uso de sustrato se ha incrementado en varios sectores agrícolas. Entre los materiales empleados para su formulación se encuentran los compost, y como todo componente es importante conocer sus propiedades previo a su uso. El objetivo de este trabajo fue caracterizar 15 compost de diferentes orígenes, para evaluarlos como componente de sustrato. Se analizaron los siguientes parámetros: densidad aparente, espacio poroso total, capacidad de retención de agua (CRA), porosidad de aireación (PA), granulometría, pH, conductividad eléctrica (CE), concentración de calcio, magnesio, potasio, sodio y nitratos. Hubo diferencias significativas (P < 0,05) entre los compost para todas las variables analizadas. La densidad aparente fue mayor en el compost de ave de corral. El compost de corteza de pino gruesa tuvo el mayor porcentaje de PA y el compost de residuos de poda el mayor porcentaje de CRA. Los compost de corteza de pino podrían ser componentes que aportarían aireación en una formulación de sustrato. Los valores de pH obtenidos se encontraron entre 4,7 a 8,7 y de CE entre 0,09 a 5,55 dS m-1. La mayoría de los compost superaron el rango adecuado de pH (5,5-6,3) y si bien la mayoría no tuvieron una CE elevada, hubo algunos como el compost de ave de corral, de residuos sólidos urbanos y de residuos porcinos que superaron 1 dS m-1, y podrían causar efectos nocivos en las plantas. Todos los compost son viables para su uso teniendo en cuenta sus propiedades y las condiciones del cultivo en que se va a utilizar el sustrato formulado.The use of substrates in agriculture has increased in recent years. Compost is one of the materials used in substrate formulation, and therefore, it is important to know its properties prior to its use. The objective of this study was to characterize 15 different types of compost from different sources in order to evaluate them as substrate components. The following parameters were determined: bulk density, total pore space, water retention capacity (Cra), aeration porosity (Pa), granulometry, pH, electrical conductivity (EC), and concentrations of calcium, magnesium, potassium, sodium and nitrates. There were significant differences (P < 0.0001) among the compost for all the variables analyzed. Poultry compost had the highest bulk density. Thick pine bark compost had the highest percentage of Pa, while pruning waste compost recorded the highest percentage of Cra . Pine bark compost could increase aeration in a substrate formulation. The pH values obtained ranged from 4.7 to 8.7, while CE values varied between 0.09 and 5.55 dS m-1. Most of the compost exceeded an optimal pH range (5.5-6.3). On the contrary, most compost did not reach high EC values. However, some types of compost, such as those from poultry, urban solid waste and pig waste, exceeded 1 dS m-1, and could cause harmful effects on plants. All types of compost are viable for use provided both compost properties and crop conditions are considered to decide which substrate to use.EEA Cerro AzulFil: Barbaro, Lorena Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Cerro Azul; ArgentinaFil: Karlanian, Monica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Floricultura; ArgentinaFil: Rizzo, Pedro Federico. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Microbiología y Zoología Agrícola; ArgentinaFil: Riera, Nicolas Iván. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Microbiología y Zoología Agrícola; Argentin