8,400 research outputs found
Invariant NKT cells and rheumatic disease: Focus on primary sjogren syndrome
Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems to play a key role in disease etiology. Invariant natural killer (NK) T cells (iNKT) are a T-cell subset able to recognize glycolipid antigens. Their function remains unclear, but studies have pointed out their ability to modulate the immune system through the promotion of specific cytokine milieu. In this review, we discussed the possible role of iNKT in pSS development, as well as their implications as future markers of disease activity
No light shining through a wall : new results from a photoregeneration experiment
Recently, axion-like particle search has received renewed interest. In
particular, several groups have started ``light shining through a wall''
experiments based on magnetic field and laser both continuous, which is very
demanding in terms of detector background. We present here the 2 limits
obtained so far with our novel set-up consisting of a pulsed magnetic field and
a pulsed laser. In particular, we have found that the axion-like particle two
photons inverse coupling constant is GeV provided that the
particle mass 1 meV. Our results definitively invalidate
the axion interpretation of the original PVLAS optical measurements with a
confidence level greater than 99.9%.Comment: Version that will appear in Physical Review Letters, Vol. 99, n. 18,
(2 Nov 2007
Finite size corrections to disordered systems on Erd\"{o}s-R\'enyi random graphs
We study the finite size corrections to the free energy density in disorder
spin systems on sparse random graphs, using both replica theory and cavity
method. We derive an analytical expressions for the corrections in the
replica symmetric phase as a linear combination of the free energies of open
and closed chains. We perform a numerical check of the formulae on the Random
Field Ising Model at zero temperature, by computing finite size corrections to
the ground state energy density.Comment: Submitted to PR
Detection of bovine papillomavirus type 2 in the peripheral blood of cattle with urinary bladder tumours: possible biological role
Bovine papillomavirus type 2 (BPV-2) infection has been associated with urinary bladder tumours in adult cattle grazing on bracken fern-infested land. In this study, we investigated the
simultaneous presence of BPV-2 in whole blood and urinary bladder tumours of adult cattle in an attempt to better understand the biological role of circulating BPV-2. Peripheral blood samples were collected from 78 cattle clinically suffering from a severe chronic enzootic haematuria. Circulating BPV-2 DNA was detected in 61 of them and in two blood samples from healthy cows. Fifty of the affected animals were slaughtered at public slaughterhouses and neoplastic proliferations in the urinary bladder were detected in all of them. BPV-2 DNA was amplified and sequenced in 78% of urinary bladder tumour samples and in 38.9% of normal samples as a control. Circulating episomal BPV-2 DNA was detected in 78.2% of the blood samples. Simultaneous presence of BPV-2 DNA in neoplastic bladder and blood samples was detected in 37 animals. Specific viral E5 mRNA and E5 oncoprotein were also detected in blood by RT-PCR
and Western blot/immunocytochemistry, respectively. It is likely that BPV-2 can persist and be maintained in an active status in the bloodstream, in particular in the lymphocytes, as a reservoir of viral infection that, in the presence of co-carcinogens, may cause the development of urinary bladder tumours
Collider Phenomenology with Split-UED
We investigate the collider implications of Split Universal Extra Dimensions.
The non-vanishing fermion mass in the bulk, which is consistent with the
KK-parity, largely modifies the phenomenology of Minimal Universal Exta
Dimensions. We scrutinize the behavior of couplings and study the discovery
reach of the Tevatron and the LHC for level-2 Kaluza-Klein modes in the
dilepton channel, which would indicates the presence of the extra dimensions.
Observation of large event rates for dilepton resonances can result from a
nontrivial fermion mass profile along the extra dimensions, which, in turn, may
corroborate extra dimensional explanation for the observation of the positron
excess in cosmic rays.Comment: 23 pages, 15 figure
Parent and self-report health-related quality of life measures in young patients with Tourette syndrome
Tourette syndrome is a neurodevelopmental disorder characterized by tics and comorbid behavioral problems. This study compared child- and parent-reported quality of life and everyday functioning. We assessed 75 children with Tourette syndrome, of which 42 (56%) had comorbid conditions (obsessive-compulsive disorder = 25; attention-deficit hyperactivity disorder = 6; both comorbidities = 4). All patients completed psychometric instruments, including the Gilles de la Tourette Syndrome-Quality of Life Scale for Children and Adolescents (child report) and the Child Tourette's Syndrome Impairment Scale (parent report). Data were compared for patients with pure Tourette syndrome, Tourette syndrome + obsessive-compulsive disorder, Tourette syndrome + attention-deficit hyperactivity disorder, and Tourette syndrome + both comorbidities. There were no group differences in quality of life. However, there were differences for total, school, and home activities impairment scores. Children and parents may not share similar views about the impact of Tourette syndrome on functioning. The measurement of health-related quality of life in Tourette syndrome is more complex in children than adults
The Ising M-p-spin mean-field model for the structural glass: continuous vs. discontinuous transition
The critical behavior of a family of fully connected mean-field models with
quenched disorder, the Ising spin glass, is analyzed, displaying a
crossover between a continuous and a random first order phase transition as a
control parameter is tuned. Due to its microscopic properties the model is
straightforwardly extendable to finite dimensions in any geometry.Comment: 10 pages, 1 figure, 1 tabl
Single Production in Collisions at the NLC
Single production in collisions at the NLC can be used to
probe the Majorana nature of the heavy neutrinos present in the Left-Right
Symmetric Model below the kinematic threshold for their direct production. For
colliders in the TeV range, typical cross sections of order
are obtained, depending on the specific choice of model parameters.
Backgrounds arising from Standard Model processes are shown to be small. This
analysis greatly extends the kinematic range of previous studies wherein the
production of an on-shell, like-sign pair of 's at the NLC was considered.Comment: 13pp, 3 figures (available on request), LaTex, SLAC-PUB-647
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