20 research outputs found
Risk assessment in contemporary outpatients with non-valvular atrial fibrillation recently on vitamin K antagonists
Atrial Fibrillation increases the risk of embolic stroke by five fold. Vitamin K
antagonists (VKAs) are still the most used oral anticoagulants in patients with nonvalvular
atrial fibrillation (NVAF) and are highly effective for the prevention of
thromboembolic (TE) complications in these patients. However, achieving the best
benefit and safety from VKAs in the clinical practice remains a major challenge mainly
because of their unpredictable anticoagulant response. In this thesis, we aimed to
evaluate the quality of oral anticoagulation in a real world cohort of patients with
NVAF recently on VKAs and to assess the risk of TE and major bleeding complications
in a contemporary cohort of outpatients with NVAF anticoagulated with VKAs.
Furthermore, in this thesis we also aimed to assess the usefulness and reliability of
different contemporary risk estimation scales in atrial fibrillation