Dynamic Models of Reputation and Competition in Job-Market Matching

A fundamental decision faced by a firm hiring employees - and a familiar one to anyone who has dealt with the academic job market, for example - is deciding what caliber of candidates to pursue. Should the firm try to increase its reputation by making offers to higher-quality candidates, despite the risk that the candidates might reject the offers and leave the firm empty-handed? Or should it concentrate on weaker candidates who are more likely to accept the offer? The question acquires an added level of complexity once we take into account the effect one hiring cycle has on the next: hiring better employees in the current cycle increases the firm's reputation, which in turn increases its attractiveness for higher-quality candidates in the next hiring cycle. These considerations introduce an interesting temporal dynamic aspect to the rich line of research on matching models for job markets, in which long-range planning and evolving reputational effects enter into the strategic decisions made by competing firms. We develop a model based on two competing firms to try capturing as cleanly as possible the elements that we believe constitute the strategic tension at the core of the problem: the trade-off between short-term recruiting success and long-range reputation-building; the inefficiency that results from underemployment of people who are not ranked highest; and the influence of earlier accidental outcomes on long-term reputations. Our model exhibits all these phenomena in a stylized setting, governed by a parameter q that captures the difference in strength between the two top candidates in each hiring cycle. We show that when q is relatively low the efficiency of the job market is improved by long-range reputational effects, but when q is relatively high, taking future reputations into account can sometimes reduce the efficiency

TIP55, a splice isoform of the KAT5 acetyltransferase, is essential for developmental gene regulation and organogenesis

Regulation of chromatin structure is critical for cell type-specific gene expression. Many chromatin regulatory complexes exist in several different forms, due to alternative splicing and differential incorporation of accessory subunits. However, in vivo studies often utilize mutations that eliminate multiple forms of complexes, preventing assessment of the specific roles of each. Here we examined the developmental roles of the TIP55 isoform of the KAT5 histone acetyltransferase. In contrast to the pre-implantation lethal phenotype of mice lacking all four Kat5 transcripts, mice specifically deficient for Tip55 die around embryonic day 11.5 (E11.5). Prior to developmental arrest, defects in heart and neural tube were evident in Tip55 mutant embryos. Specification of cardiac and neural cell fates appeared normal in Tip55 mutants. However, cell division and survival were impaired in heart and neural tube, respectively, revealing a role for TIP55 in cellular proliferation. Consistent with these findings, transcriptome profiling revealed perturbations in genes that function in multiple cell types and developmental pathways. These findings show that Tip55 is dispensable for the pre- and early post-implantation roles of Kat5, but is essential during organogenesis. Our results raise the possibility that isoform-specific functions of other chromatin regulatory proteins may play important roles in development

The Grizzly, November 13, 2003

The Power of Puppets: Spiral Q at Ursinus • Registration Frustration • Philly Re-elects John Street as Mayor • First Injectable Male Contraceptive • Campus Connection: Spotlight on NYU and Student Suicide • Rush Begins at Ursinus • Cellphones Used to Cheat: Will This Technology Tempt Students at Ursinus? • Opinions: John Street: A Better Choice for Philadelphia Mayor; Die in Peace or Stay Alive?; Careers over Children; Why You Should Vote • Academy of Sportfighting • Networking for Holidays • Halloween Extravaganzas: Frightful Night for the Senior Class; Smoking Party • Musical Performances in UC History • Myrin Library now Recycles! • Field Hockey\u27s Season Cut Short • Women\u27s Soccer Team has a Record Breaking Season • UC Football: Skid Continueshttps://digitalcommons.ursinus.edu/grizzlynews/1548/thumbnail.jp

Stakeholder-driven development and implementation of CRICIT: an app to support high-quality data capture and protocol monitoring for outpatient clinical trials with vulnerable populations

Abstract Introduction:Choosing an appropriate electronic data capture system (EDC) is a critical decision for all randomized controlled trials (RCT). In this paper, we document our process for developing and implementing an EDC for a multisite RCT evaluating the efficacy and implementation of an enhanced primary care model for individuals with opioid use disorder who are returning to the community from incarceration. Methods:Informed by the Knowledge-to-Action conceptual framework and user-centered design principles, we used Claris Filemaker software to design and implement CRICIT, a novel EDC that could meet the varied needs of the many stakeholders involved in our study. Results:CRICIT was deployed in May 2021 and has been continuously iterated and adapted since. CRICIT’s features include extensive participant tracking capabilities, site-specific adaptability, integrated randomization protocols, and the ability to generate both site-specific and study-wide summary reports. Conclusions:CRICIT is highly customizable, adaptable, and secure. Its implementation has enhanced the quality of the study’s data, increased fidelity to a complicated research protocol, and reduced research staff’s administrative burden. CRICIT and similar systems have the potential to streamline research activities and contribute to the efficient collection and utilization of clinical research data

The role of retailer's performance in optimal wholesale price discount policies

The main goal of this paper is to model the effects of wholesale price control on manufacturer’s profit, taking explicitly into account the retailer’s sales motivation and performance. We consider a stylized distribution channel where a manufacturer sells a single kind of good to a single retailer. Wholesale price discounts are assumed to increase the retailer’s motivation thus improving sales. We study the manufacturer’s profit maximization problem as an optimal control model where the manufacturer’s control is the discount on wholesale price and retailer’s motivation is one of the state variables. In particular in the paper we prove that an increasing discount policy is optimal for the manufacturer when the retailer is not efficient while efficient retailers may require to decrease the trade discounts at the end of the selling period. Computational experiments point out how the discount on wholesale price passed by the retailer to the market (passthrough) influences the optimal profit of the manufacturer

The Grizzly, November 20, 2003

Can I Kiss You? • Grade Your Professors Today: Website Spotlight • Did Veterans Day Pass you by? • Opinions: Celebrity Couples: Do we Really Care That Much?; GSA Forum Celebrates the Essence of a Liberal Arts Education; Search for the Right Search Engine; Concerning the Residential Village • All American Cafe • Ursinus College Presents: The Love of the Nightingale; Meet the Director • Come Support Jazz and Concert Bands • Men\u27s Basketball Season Looks Promising • Women\u27s Basketball Team Young, yet Optimistichttps://digitalcommons.ursinus.edu/grizzlynews/1549/thumbnail.jp

The Grizzly, September 25, 2003

The State of Iraq: Critical, but not Hopeless says Trudy Rubin • Family Day Celebrates Students\u27 Second Home • The Journey of a Lifetime • Aftermath of Isabel: A Photo Essay • SERV Serves Students During Campus Emergencies • Opinions: Common Sentiments About the Common Experience; UC Fashion: Mood-Based; People Want to Know the Real Truth; WTO Talks Collapse: Possibly a Good Thing; Out of the Middle East: Part 3 • Collegeville\u27s Hot Spots • Playwriting Debut • Meet the Star Among Us • London Living: A Warm City • The Outhouse Revisited: A Review • Field Hockey: Young Sets School Record in 5-0 win • Men\u27s Soccer: Continuing to Battle Against Tough Competition • UC Football: Albright Stomps the Bearshttps://digitalcommons.ursinus.edu/grizzlynews/1542/thumbnail.jp

CRISPR-enhanced human adipocyte \u27browning\u27 as cell therapy for metabolic disease [preprint]

Obesity and type 2 diabetes (T2D) are associated with poor tissue responses to insulin [1,2], disturbances in glucose and lipid fluxes [3-5] and comorbidities including steatohepatitis [6] and cardiovascular disease [7,8]. Despite extensive efforts at prevention and treatment [9,10], diabetes afflicts over 400 million people worldwide [11]. Whole body metabolism is regulated by adipose tissue depots [12-14], which include both lipid-storing white adipocytes and less abundant \u27brown\u27 and \u27brite/beige\u27 adipocytes that express thermogenic uncoupling protein UCP1 and secrete factors favorable to metabolic health [15-18]. Application of clustered regularly interspaced short palindromic repeats (CRISPR) gene editing [19,20] to enhance \u27browning\u27 of white adipose tissue is an attractive therapeutic approach to T2D. However, the problems of cell-selective delivery, immunogenicity of CRISPR reagents and long term stability of the modified adipocytes are formidable. To overcome these issues, we developed methods that deliver complexes of SpyCas9 protein and sgRNA ex vivo to disrupt the thermogenesis suppressor gene NRIP1 [21,22] with near 100% efficiency in human or mouse adipocytes. NRIP1 gene disruption at discrete loci strongly ablated NRIP1 protein and upregulated expression of UCP1 and beneficial secreted factors, while residual Cas9 protein and sgRNA were rapidly degraded. Implantation of the CRISPR-enhanced human or mouse brown-like adipocytes into high fat diet fed mice decreased adiposity and liver triglycerides while enhancing glucose tolerance compared to mice implanted with unmodified adipocytes. These findings advance a therapeutic strategy to improve metabolic homeostasis through CRISPR-based genetic modification of human adipocytes without exposure of the recipient to immunogenic Cas9 or delivery vectors

The Grizzly, October 16, 2003

Feeling Drained for a Good Cause: Omega Chi Blood Drive • CAB Laugh-off Left Students Rolling in the Aisles • UC in the City Program Announces Easier Access to Philly • Political Pagemakers: Democratic Candidates for President • California Recall Circus has its Star • Club Spotlight: Forensics • Opinions: UC in the City: An Attempt to Fight the Boredom; California Recall Election Democracy at its Best; Video Games as Government Training Tools; Flu Season is Near; Legal BAC Should Still be Lower; Myrin Library: Use It • On the Verge Review: Memorable • Believe it or Not: A Tree in the End Zone • Meet Dr. Zwerling • Job Fair Success • 2003 Homecoming Court • Women\u27s Rugby: A Tough and Spirited Group of Ladies • Field Hockey Team Remains Undefeated in Conference • Men\u27s Soccer Continues to Face Tough Losses • Volleyball 2-3 in Conference Play • Sue Hadfield Named Head Swimming Coachhttps://digitalcommons.ursinus.edu/grizzlynews/1545/thumbnail.jp