Outcomes of conjunctival compression sutures for hypotony after glaucoma filtering surgery

3openopenQuaranta L.; Riva I.; Floriani I.C:Quaranta, Luciano; Riva, Ivano; Floriani I., C

Los saurios y anfisbénidos de Bolivia (Reptilia, Squamata): lista patrón, localidades y bibliografía

The number of Bolivian lizards and amphisbaenids is increased from 79 (Fugler, 1989) to 102 in this updated and comprehensive list, which includes all new species and taxonomic changes published recently, as well as locality data. Coordinates for the localities are provided in a locality list. Three species are reported herein for the first time: Kentropyx pelviceps, Liolaemus schmidti, and Uranoscodon superciliosus.El número de saurios y anfisbénidos conocidos en Bolivia se incrementa de 79 especies (Fugler, 1989) a 102 en la presente lista actualizada, que incorpora todas las especies nuevas, los cambios taxonómicos recientes y todas las localidades de colecta conocidas con sus coordenadas. Tres especies son citadas para Bolivia por primera vez en este trabajo: Kentropyx pelviceps, Liolaemus schmidti y Uranoscodon superciliosus

Sensitivity Analysis and Quantification of the Role of Governing Transport Mechanisms and Parameters in a Gas Flow Model for Low-Permeability Porous Media

Recent models represent gas (methane) migration in low-permeability media as a weighted sum of various contributions, each associated with a given flow regime. These models typically embed numerous chemical/physical parameters that cannot be easily and unambiguously evaluated via experimental investigations. In this context, modern sensitivity analysis techniques enable us to diagnose the behavior of a given model through the quantification of the importance and role of model input uncertainties with respect to a target model output. Here, we rely on two global sensitivity analysis approaches and metrics (i.e., variance-based Sobol’ indices and moment-based AMA indices) to assess the behavior of a recent interpretive model that conceptualizes gas migration as the sum of a surface diffusion mechanism and two weighted bulk flow components. We quantitatively investigate the impact of (i) each uncertain model parameter and (ii) the type of their associated probability distribution on the evaluation of methane flow. We then derive the structure of an effective diffusion coefficient embedding all complex mechanisms of the model considered and allowing quantification of the relative contribution of each flow mechanism to the overall gas flow

Analisis Faktor yang Mempengaruhi Pendapatan Petani Padi Pengguna Pupuk Organik dan Anorganik di Kecamatan Harau

Penelitian ini dilatar belakangi oleh adanya ketergantungan petani menggunakan pupuk anorganik dan meningkatnya harga pupuk anorganik tersebut yang berakibat pada bertambahnya biaya produksi dan berkurangnya keuntungan USAhatani padi, sehingga berpengaruh terhadap kesejahteraan keluarga petani. Berdasarkan penelitian sebelumnya diperoleh informasi bahwa terdapat perbedaan pendapatan petani padi pengguna pupuk organik dengan pendapatan petani padi pengguna pupuk anorganik di Kecamatan Harau. Oleh karena itu, tujuan dari penelitian ini adalah untuk menganalisis faktor-faktor yang mempengaruhi pendapatan petani padi pengguna pupuk organik dan anorganik di Kecamatan Harau. Penelitian ini dilakukan dengan menggunakan survey kepada petani padi di Kecamatan Harau. Analisa data dilakukan secara kuantitatif yaitu melalui analisa regresi linier berganda dan dilanjutkan dengan uji F. Berdasarkan hasil penelitian diketahui bahwa faktor yang  mempengaruhi  secara  nyata  pendapatan  petani  padi pengguna pupuk organik dan anorganik  di  Kecamatan  Harau adalah: Luas lahan dan biaya produksi. Sedangkan faktor  yang mempengaruhi secara tidak nyata adalah: umur petani, pendidikan petani, jumlah produksi dan harga produksi

Efficacy and safety of trabeculectomy vs nonpenetrating surgical procedures: a systematic review and meta-analysis

To date, only a few studies have directly compared nonpenetrating surgery (NPS) and trabeculectomy (TE). Therefore, there is no strong evidence as to which surgical technique leads to the best results in terms of ocular hypotensive effect and safety

An original deconvolution approach for oil production allocation based on geochemical fingerprinting

We tackle oil commingling scenarios and develop an original deconvolution approach for geochemical production allocation. This yields robust assessment of the proportions of oils forming a mixture originating from commingling oils associated with diverse reservoirs or, wells. Our study starts from considering that production allocation performed by means of geochemical fingerprinting is relevant in the context of modern and sustainable use of georesources, with the added benefit of favoring shared facilities and production equipment. A geochemical production allocation workflow is typically structured according to two steps: (i) determination of the chromatograms associated with the mixture (and eventually with each of the End Members, EMs, constituting the fluids in the mixture), and (ii) the use of a deconvolution algorithm to estimate the mass fraction of each EM. Concerning the latter step, we introduce an original approach and the ensuing deconvolution algorithm (hereafter termed PGM) that does not require additional laboratory efforts in comparison with traditional approaches. We also present extensions of widely used deconvolution algorithms, which we frame in a (stochastic) Monte Carlo context to improve their robustness and reliability. The new PGM approach is assessed jointly with a suite of typically used approaches and algorithms against new laboratory-based commingling scenarios. The latter are based on the design and introduction of a novel and low-cost experimental method. The results of the study (i) constitute a unique and rigorous comparison of the traditionally employed production allocation deconvolution algorithms, (ii) document the critical importance of the number of features of the chromatograms used during a quantitative deconvolution, and (iii) suggest that our new PGM approach is very robust and accurate compared to existing approaches

Differential allelic expression of SOS1 and hyperexpression of the activating SOS1 c.755C variant in a Noonan syndrome family

Noonan syndrome (NS) is a genetic condition characterized by congenital heart defects, short stature and characteristic facial features. We here present the case of a girl with moderate learning disabilities, delayed language development, craniofacial features and skin anomalies reminiscent of NS. After a mutation screening of the known NS genes PTPN11, SOS1, RAF1, KRAS, GRB2, BRAF and SHOC2 we found the heterozygous c.755T>C variant in SOS1 causing the p.I252T amino-acid substitution, which was considered possibly pathogenetic by bioinformatic predictions. The same variant was present in the proband's mother, displaying some NS features, and mateRNAl grandfather showing no NS traits, but also by a healthy subject in 1000 genomes project database without phenotype informations. The functional analysis revealed that SOS1 c.755C activated the RAS-ERK intracellular pathway, whereas no effects on RAC-JNK cascade have been detected. After a comparison between the sequence of SOS1 cDNA from peripheral blood and SOS1 genomic DNA, we showed for the first time a differential allelic expression of the SOS1 gene in healthy individuals, thus occurring as a physiologic condition. Interestingly, we found that the mutated allele C was 50% more expressed than the wild-type allele T in all familial carriers. The comparable amount of SOS1 mRNA between mutated individuals and the controls indicates that the variant does not affect SOS1 expression. The present study provides a first evidence of allelic imbalance of SOS1 and pinpoints this condition as a possible mechanism underlying a different penetrance of some SOS1-mutated alleles in unrelated carriers