Factors contributing to the time taken to consult with symptoms of lung cancer: a cross-sectional study

<b>Objectives</b>: To determine what factors are associated with the time people take to consult with symptoms of lung cancer, with a focus on those from rural and socially deprived areas. <b>Methods</b>: A cross-sectional quantitative interview survey was performed of 360 patients with newly diagnosed primary lung cancer in three Scottish hospitals (two in Glasgow, one in NE Scotland). Supplementary data were obtained from medical case notes. The main outcome measures were the number of days from (1) the date participant defined first symptom until date of presentation to a medical practitioner; and (2) the date of earliest symptom from a symptom checklist (derived from clinical guidelines) until date of presentation to a medical practitioner. <b>Results</b>: 179 participants (50%) had symptoms for more than 14 weeks before presenting to a medical practitioner (median 99 days; interquartile range 31–381). 270 participants (75%) had unrecognised symptoms of lung cancer. There were no significant differences in time taken to consult with symptoms of lung cancer between rural and/or deprived participants compared with urban and/or affluent participants. Factors independently associated with increased time before consulting about symptoms were living alone, a history of chronic obstructive pulmonary disease (COPD) and longer pack years of smoking. Haemoptysis, new onset of shortness of breath, cough and loss of appetite were significantly associated with earlier consulting, as were a history of chest infection and renal failure. <b>Conclusion</b>: For many people with lung cancer, regardless of location and socioeconomic status, the time between symptom onset and consultation was long enough to plausibly affect prognosis. Long-term smokers, those with COPD and/or those living alone are at particular risk of taking longer to consult with symptoms of lung cancer and practitioners should be alert to this

Induced currents, frozen charges and the quantum Hall effect breakdown

Puzzling results obtained from torque magnetometry in the quantum Hall effect (QHE) regime are presented, and a theory is proposed for their explanation. Magnetic moment saturation, which is usually attributed to the QHE breakdown, is shown to be related to the charge redistribution across the sample.Comment: 5 pages, 2 figures, Proceedings of the 11th International Symposium "Nanostructures: Physics and Technology", St.Petersburg, Russia, June 23-28, 2003, expanded version with one figure adde

Enhanced indistinguishability of in-plane single photons by resonance fluorescence on an integrated quantum dot

Integrated quantum light sources in photonic circuits are envisaged as the building blocks of future on-chip architectures for quantum logic operations. While semiconductor quantum dots have been proven to be the highly efficient emitters of quantum light, their interaction with the host material induces spectral decoherence, which decreases the indistinguishability of the emitted photons and limits their functionality. Here, we show that the indistinguishability of in-plane photons can be greatly enhanced by performing resonance fluorescence on a quantum dot coupled to a photonic crystal waveguide. We find that the resonant optical excitation of an exciton state induces an increase in the emitted single-photon coherence by a factor of 15. Two-photon interference experiments reveal a visibility of 0.80 ± 0.03, which is in good agreement with our theoretical model. Combined with the high in-plane light-injection efficiency of photonic crystal waveguides, our results pave the way for the use of this system for the on-chip generation and transmission of highly indistinguishable photons

Probing e-e interactions in a periodic array of GaAs quantum wires

We present the results of non-linear tunnelling spectroscopy between an array of independent quantum wires and an adjacent two-dimensional electron gas (2DEG) in a double-quantum-well structure. The two layers are separately contacted using a surface-gate scheme, and the wires are all very regular, with dimensions chosen carefully so that there is minimal modulation of the 2DEG by the gates defining the wires. We have mapped the dispersion spectrum of the 1D wires down to the depletion of the last 1D subband by measuring the conductance \emph{G} as a function of the in-plane magnetic field \emph{B}, the interlayer bias $V_{\rm dc}$ and the wire gate voltage. There is a strong suppression of tunnelling at zero bias, with temperature and dc-bias dependences consistent with power laws, as expected for a Tomonaga-Luttinger Liquid caused by electron-electron interactions in the wires. In addition, the current peaks fit the free-electron model quite well, but with just one 1D subband there is extra structure that may indicate interactions.Comment: 3 pages, 3 figures; formatting correcte

A prova de exercício cárdio-pulmonar e o prognóstico cirúrgico do cancro do pulmão

Resumo: Os autores procuram dar mais um contributo para a avaliação pré-operatória dos doentes com carcinoma de não pequenas células que vão ser sujeitos a cirurgia de ressecção pulmonar.Trata-se de um estudo prospectivo onde foi avaliado o resultado da cirurgia em termos de complicações ocorridas nos 30 dias a seguir à operação. Os autores definiram cada uma das complicações (óbito, enfarte do miocárdio, insuficiências respiratória, cardíaca e renal, embolia pulmonar, pneumonia e septicemia) e ainda analisaram 3 dessas complicações em separado (óbito, enfarte do miocárdio e insuficiência respiratória), as quais designaram por âfraco resultadoâ.Antes da cirurgia, foram avaliados 99 doentes (34 pneumectomias, 56 lobectomias, 6 bilobectomias e 3 ressecções atípicas) com espirometria (FEV1 em litros) e consumo de oxigénio no exercício máximo (VO2peak). Só 26 doentes tinham valores funcionais considerados borderline (FEV1 < 1,5 litros para lobectomia e < 2,0 litros para pneumectomia). Nos resultados apresentados observámos os seguintes valores médios: FEV1=2,06 litros; FEV1=80,4% do valor teórico; VO2peak=18,8 ml/kg/min ou 88,3% do valor teórico. Só existiram 4 óbitos (4%) e 21 doentes tiveram uma ou mais das complicações referenciadas.Os autores não encontraram relação significativa entre as complicações pós-operatórias e o FEV1 em litros. Verificaram ainda que o VO2peak em percentagem do valor teórico previa melhor um âfraco resultadoâ do que o mesmo parâmetro em valor absoluto.Em relação aos óbitos, um dos doentes tinha sido submetido a quimioterapia, o que dificultou a avaliação do desfecho. Nos restantes 3 óbitos, todos os doentes tinham um VO2peak < 62% do valor teórico. Dois dos 3 doentes com VO2peak < 50% tiveram um âfraco resultadoâ. Com VO2peak > 75% só 3 em 20 doentes é que tiveram um âfraco resultadoâ.Apesar de reconhecerem a necessidade de mais e maiores estudos, os autores concluem que VO2peak é importante para prever complicações como óbito, enfarte do miocárdio ou insuficiência respiratória, principalmente se é referido em percentagem do valor teórico. O limite âseguroâ situar-se-ia entre 50 e 60% do valor previsto

Gigahertz-clocked teleportation of time-bin qubits with a quantum dot in the telecommunication C Band

Teleportation is a fundamental concept of quantum mechanics with an important application in extending the range of quantum communication channels via quantum relay nodes. To be compatible with real-world technology such as secure quantum key distribution over fiber networks, such a relay node should ideally operate at gigahertz clock rates and accept time-bin-encoded qubits in the low-loss telecom band around 1550 nm. Here, we show that In As-In P droplet-epitaxy quantum dots, with their sub-Poissonian emission near 1550 nm, are ideally suited for the realization of this technology. To create the necessary on-demand photon emission at gigahertz clock rates, we develop a flexible-pulsed optical-excitation scheme and demonstrate that the fast driving conditions are compatible with a low multiphoton emission rate. We show further that, even under these driving conditions, photon pairs obtained from the biexciton cascade show an entanglement fidelity close to 90%, comparable to the value obtained under continuous-wave excitation. Using asymmetric Mach-Zehnder interferometers and our photon source, we finally construct a time-bin qubit quantum relay able to receive and send time-bin-encoded photons and demonstrate mean teleportation fidelities of 0.82 ± 0.01, exceeding the classical limit by more than ten standard deviations

A quantum dot as a source of time-bin entangled multi-photon states

A quantum computer has the potential to revolutionize multiple industries by enabling a drastic speed-up relative to classical computers for certain quantum algorithms and simulations. Linear optical quantum computing is an approach that uses photons as qubits, which are known for suffering little from decoherence. A source of multiple entangled and indistinguishable photons would be a significant step in the development of an optical quantum computer. Consequently, multiple proposals for the generation of such a stream of photons have recently been put forward. Here we introduce an alternative scheme based on a semiconductor quantum dot (QD) embedded in an optical microcavity in a magnetic field. A single charge carrier trapped in the dot has an associated spin that can be controlled by ultrashort optical pulses. Photons are sequentially generated by resonant scattering from the QD, while the charge spin is used to determine the encoding of the photons into time-bins. In this way a multi-photon entangled state can be gradually built up. With a simple optical pulse sequence we demonstrate a proof of principle experiment of our proposal by showing that the time-bin of a single photon is dependent on the measured state of the trapped charge spin

A Compact Beam Stop for a Rare Kaon Decay Experiment

We describe the development and testing of a novel beam stop for use in a rare kaon decay experiment at the Brookhaven AGS. The beam stop is located inside a dipole spectrometer magnet in close proximity to straw drift chambers and intercepts a high-intensity neutral hadron beam. The design process, involving both Monte Carlo simulations and beam tests of alternative beam-stop shielding arrangements, had the goal of minimizing the leakage of particles from the beam stop and the resulting hit rates in detectors, while preserving maximum acceptance for events of interest. The beam tests consisted of measurements of rates in drift chambers, scintilation counter hodoscopes, a gas threshold Cherenkov counter, and a lead glass array. Measurements were also made with a set of specialized detectors which were sensitive to low-energy neutrons, photons, and charged particles. Comparisons are made between these measurements and a detailed Monte Carlo simulation.Comment: 39 pages, 14 figures, submitted to Nuclear Instruments and Method

Modelling of strain effects in manganite films

Thickness dependence and strain effects in films of $La_{1-x}A_xMnO_3$ perovskites are analyzed in the colossal magnetoresistance regime. The calculations are based on a generalization of a variational approach previously proposed for the study of manganite bulk. It is found that a reduction in the thickness of the film causes a decrease of critical temperature and magnetization, and an increase of resistivity at low temperatures. The strain is introduced through the modifications of in-plane and out-of-plane electron hopping amplitudes due to substrate-induced distortions of the film unit cell. The strain effects on the transition temperature and transport properties are in good agreement with experimental data only if the dependence of the hopping matrix elements on the $Mn-O-Mn$ bond angle is properly taken into account. Finally variations of the electron-phonon coupling linked to the presence of strain turn out important in influencing the balance of coexisting phases in the filmComment: 7 figures. To be published on Physical Review