Green urine from propofol

"A 65-year-old female, with past medical history of hypertension and chronic hypoxemic respiratory failure due to chronic obstructive pulmonary disease (COPD), was admitted after endoscopic resection of colonic polyps and a large rectal mass. For this procedure, general anesthesia with intravenous Propofol was utilized. Due to technical difficulty of the procedure, the total anesthesia time was 7 hours and 48 minutes with a total use of 2,951.06 mg of Propofol. On post-procedure day #1, the patient's urine was noted to be green (Figure 1). The patient denied dysuria, frequency, urgency, and foul smell. Additionally, liver function tests, renal function tests, complete blood count, and urinalysis were all within normal limits."Cole T. Bredehoeft (1), Rebecca T. Rist (2), Christian A. Rojas-Moreno (2,3); 1. School of Medicine, University of Missouri. 2. Department of Medicine, University of Missouri. 3. Division of Infectious Diseases, Department of Medicine, University of Missouri.Includes bibliographical reference

Synthetic lethal interactions in yeast reveal functional roles of J protein co-chaperones

J proteins are a diverse family of co-chaperones that cooperate with heat shock protein 70 (Hsp70) to coordinate protein quality control, especially in response to cellular stress. Current models suggest that individual J proteins might play roles in recruiting Hsp70s to specific functions, such as maintaining cell wall integrity or promoting ribosome biogenesis. However, relatively few stresses have been used to test this model and, as a result, only a few specific activities have been identified. To expand our understanding of the J protein network, we used a synthetic lethal approach in which 11 Saccharomyces cerevisiae deletion strains were treated with 12 well-characterized chemical inhibitors. The results defined new roles for specific J proteins in major signaling pathways. For example, an important role for Swa2 in cell wall integrity was identified and activities of the under-explored Jjj1, Apj1, Jjj3 and Caj1 proteins were suggested. More generally, these findings support a model in which some J proteins, such as Ydj1 and Zuo1, play “generalist” roles, while others, such as Apj1 and Jjj2, are “specialists”, having roles in relatively few pathways. Together, these results provide new insight into the network of J proteins

Citizen Science as an Approach for Overcoming Insufficient Monitoring and Inadequate Stakeholder Buy-in in Adaptive Management: Criteria and Evidence

Adaptive management is broadly recognized as critical for managing natural resources, yet in practice it often fails to achieve intended results for two main reasons: insufficient monitoring and inadequate stakeholder buy-in. Citizen science is gaining momentum as an approach that can inform natural resource management and has some promise for solving the problems faced by adaptive management. Based on adaptive management literature, we developed a set of criteria for successfully addressing monitoring and stakeholder related failures in adaptive management and then used these criteria to evaluate 83 citizen science case studies from peer-reviewed literature. The results suggest that citizen science can be a cost-effective method to collect essential monitoring information and can also produce the high levels of citizen engagement that are vital to the adaptive management learning process. The analysis also provides a set of recommendations for citizen science program design that addresses spatial and temporal scale, data quality, costs, and effective incentives to facilitate participation and integration of findings into adaptive management