L'Estuaire (65)

Éditorial: La relance de la revue de l'Estuaire: 15 ans déjà! -- Le chemin de fer et le tourisme au Bas-Saint-Laurent -- Les dames Drapeau -- Histoire oubliée: Une étrange odyssée...des Madelinots s'établissent sur l'Île Nepawa (Abitibi) en 1941 -- Étude démographique de la population de Rimouski 1701-1750 -- Sur la piste des forêts du passé -- Mgr Courchesne: la récupération des forêts pour la colonisation -- Joseph-Pierre Ouellet, 2e architecte de l'église de Trois-Pistoles -- La seigneurie de l'Anse-aux-Coques ou de Lepage-Thivierge -- Nouvelles brèves -- Livres à lir

L'Estuaire, vol. 24 (1)

Éditorial -- Mémoires de guerre d'un Gaspésien -- Emmanuel Coulombe : sur la route d'un menuisier -- Rimouski au temps d'Adèle Lamontagne 1858-1875. Partie 3: Commerce et société -- La pêche au saumon dans l'anse aux Coques -- Le Bas-Saint-Laurent et le fleuve: des relations disparues -- L'aéroport de Rimouski: quelques notes historiques -- Chroniques rimouskoises: Le Séminaire de Rimouski (1863-1967): repères chronologiques -- Vieux écrits: Marius Barbeau et le folklore de la côte nord gaspésienne -- Nouvelles brèves -- Des livres à lire

Cytoplasmic PAR-3 protein expression is associated with adverse prognostic factors in clear cell renal cell carcinoma and independently impacts survival.

International audienceClear cell renal cell carcinomas (ccRCCs) represent 70% of renal cancers, and several clinical and histolopathological factors are implicated in their prognosis. We recently demonstrated that the overexpression of PAR-3 protein encoded by the PARD3 gene could be implicated in renal oncogenesis. The object of this work was to study the association of intratumoral PAR-3 expression with known prognostic parameters and clinical outcome. In this aim, PAR-3 expression was assessed by immunohistochemistry in ccRCC tumors of 101 patients from 2003 to 2005. The immunostaining of PAR-3 was scored either as membranous (mPAR-3) or as both membranous and cytoplasmic (cPAR-3). Cytoplasmic PAR-3 was significantly associated with worse histopathological and clinical prognostic factors: Fuhrman grades 3 and 4, tumor necrosis, sarcomatoid component, adrenal invasion, renal and hilar fat invasion, eosinophilic component, a noninactivated VHL gene, higher tumor grade, lymph node involvement, metastasis, and worse clinical Eastern Cooperative Oncology Group and S classification scores. After multivariate analysis, 2 parameters were independently associated with cPAR-3: necrosis and eosinophilic components. In addition, cPAR-3 patients had shorter overall and progression-free survivals independently from strong prognostic validated factors like metastases. A cytoplasmic expression of PAR-3 is therefore implicated in worse clinical and pathological cancer features in ccRCC and could be useful to identify patients with high-risk tumors