An Integrated Learning Approach to Teaching an Undergraduate Information Systems Course

This paper describes the redesign and implementation of an introductory Information Systems class. The redesign was guided by principles drawn from the experiential and active learning literature. Central to the redesign are two simulated companies: petGRO, a fictional ERP-enabled pet food and accessories e-tailer; and beans4all, a technology consulting company of which all registered students are employees. Students work in solution crews throughout the semester to solve a set of technology-related challenges that their client, petGRO, is facing. Initial student response to the redesign has been mixed. Survey responses indicate that students have an increased interest in IS after taking the course. There was a significant increase in students’ perception of the usefulness of the knowledge gained from the course in subsequent courses. However, this result is countered by a decrease in students’ perception of whether the course led to an improvement in their academic skills. Open-ended comments reveal the polarizing nature of the redesign but with more positive than negative comments

Development of a drainage and flood control management program for urbanizing communities. Part I

Submitted to Office of Water Research and Technology, U.S. Dept. of Interior.Bibliography: pages [29]-41.September 1978.Urbanization causes an alteration of the stormwater runoff response of the urbanizing watershed which, in turn, increases stormwater damages downstream. Few communities have successfully implemented programs for managing these development induced drainage impacts due in part to the uncertainties associated with any drainage management program. Which rainfall-runoff model should be used, how sensitive is project analysis to poor discharge prediction, how should project cost be allocated, and so on. The objective of this research is to clarify these uncertainties and develop a readily implementable drainage and flood control management program for the mitigation of development-induced drainage impacts. These objectives are realized through a detailed examination of and recommendation on the three major elements of a drainage management program: the Technical element which establishes the method of flood hydrology calculation, the Financial element which establishes the methods for drainage and flood control cost calculation and cost allocation, and the Regulatory element which establishes the enforcement mechanism of the drainage management program. The recommended Technical element is based on the sensitivity of project analysis to poor runoff prediction, and on the predictive capability of various rainfall-runoff models. This predictive capability was evaluated for some of the more popular rainfall-runoff models through a statistical analysis of published results from those models. The recommended Financial element is based on a thorough review of the legal issues regarding: 1) municipal and developer liability with respect to development-induced drainage impacts, 2) project cost calculation, and 3) project cost apportionment. A new approach for apportioning drainage and flood control facility costs between developers and the municipal government is presented. The approach utilizes existing engineering analysis techniques to divide project costs in proportion to the reduced liability attributable to the developers and to the municipal government. Two Regulatory elements are proposed for the drainage management program. The changes to existing legislation that are necessary to enforce the drainage management program under the proposed regulatory component are discussed and sample legislation is included for each. The report is divided into two parts. Part II is the complete project report with detailed discussions of the methods and data used, and of the research findings. Part I is written as a user publication. It summarizes the research methods and results, and discusses the recommended drainage management program.OWRT Project no. B-161-COLO; supported in part by funds provided by the United States Department of the Interior, Office of Water Research and Technology, as authorized by the Water Resources Research Act of 1964, and pursuant to Grant Agreement No.(s) 14-34-0001-7112; and in part by funds provided by the Urban Drainage and Flood Control District, Denver, Colorado; and in part by the City of Lakewood, Colorado

Autologous stromal vascular fraction therapy for rheumatoid arthritis: rationale and clinical safety

Advancements in rheumatoid arthritis (RA) treatment protocols and introduction of targeted biological therapies have markedly improved patient outcomes, despite this, up to 50% of patients still fail to achieve a significant clinical response. In veterinary medicine, stem cell therapy in the form of autologous stromal vascular fraction (SVF) is an accepted therapeutic modality for degenerative conditions with 80% improvement and no serious treatment associated adverse events reported. Clinical translation of SVF therapy relies on confirmation of veterinary findings in targeted patient populations. Here we describe the rationale and preclinical data supporting the use of autologous SVF in treatment of RA, as well as provide 1, 3, 6, and 13 month safety outcomes in 13 RA patients treated with this approach

Feasibility of combination allogeneic stem cell therapy for spinal cord injury: a case report

Cellular therapy for spinal cord injury (SCI) is overviewed focusing on bone marrow mononuclear cells, olfactory ensheathing cells, and mesenchymal stem cells. A case is made for the possibility of combining cell types, as well as for allogeneic use. We report the case of 29 year old male who suffered a crush fracture of the L1 vertebral body, lacking lower sensorimotor function, being a score A on the ASIA scale. Stem cell therapy comprised of intrathecal administration of allogeneic umbilical cord blood ex-vivo expanded CD34 and umbilical cord matrix MSC was performed 5 months, 8 months, and 14 months after injury. Cell administration was well tolerated with no adverse effects observed. Neuropathic pain subsided from intermittent 10/10 to once a week 3/10 VAS. Recovery of muscle, bowel and sexual function was noted, along with a decrease in ASIA score to "D". This case supports further investigation into allogeneic-based stem cell therapies for SCI

Groups of diffeomorphisms and geometric loops of manifolds over ultra-normed fields

The article is devoted to the investigation of groups of diffeomorphisms and loops of manifolds over ultra-metric fields of zero and positive characteristics. Different types of topologies are considered on groups of loops and diffeomorphisms relative to which they are generalized Lie groups or topological groups. Among such topologies pairwise incomparable are found as well. Topological perfectness of the diffeomorphism group relative to certain topologies is studied. There are proved theorems about projective limit decompositions of these groups and their compactifications for compact manifolds. Moreover, an existence of one-parameter local subgroups of diffeomorphism groups is investigated.Comment: Some corrections excluding misprints in the article were mad

Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis

The stromal vascular fraction (SVF) of adipose tissue is known to contain mesenchymal stem cells (MSC), T regulatory cells, endothelial precursor cells, preadipocytes, as well as anti-inflammatory M2 macrophages. Safety of autologous adipose tissue implantation is supported by extensive use of this procedure in cosmetic surgery, as well as by ongoing studies using in vitro expanded adipose derived MSC. Equine and canine studies demonstrating anti-inflammatory and regenerative effects of non-expanded SVF cells have yielded promising results. Although non-expanded SVF cells have been used successfully in accelerating healing of Crohn's fistulas, to our knowledge clinical use of these cells for systemic immune modulation has not been reported. In this communication we discuss the rationale for use of autologous SVF in treatment of multiple sclerosis and describe our experiences with three patients. Based on this rationale and initial experiences, we propose controlled trials of autologous SVF in various inflammatory conditions

A phase I and pharmacologic study of the combination of bortezomib and pegylated liposomal doxorubicin in patients with refractory solid tumors

Pre-clinical studies combining the proteasome inhibitor bortezomib with anthracyclines have shown enhanced anti-tumor activity. We therefore conducted a phase I trial of bortezomib and pegylated liposomal doxorubicin (PLD) in patients with refractory solid tumors

Estado, escolas e famílias: públicos escolares e regulação da educação

O texto apresenta alguns resultados de uma investigação recentemente concluída que, genericamente, se inscreve nos complexos processos de (multi)regulação da educação. O estudo desenvolveu-se num concelho do norte de Portugal (convencionalmente designado Vila Formosa), circunscrevendo-se às escolas com oferta de ensino secundário. A análise dos dados sugere que, na topografia complexa dos processos de (multi)regulação do campo escolar, a combinação de medidas de política educativa com recursos e cursos de acção que as diferentes escolas e as diversas categorias de famílias e jovens detêm e adoptam constituem uma tríade de fontes de dinâmicas, umas vezes convergentes, outras vezes em tensão que, por seus efeitos sociológicos cumulativos, geram a reordenação do campo de lutas concorrenciais em torno da educação, lutas essas que parecem penalizar sobretudo as famílias que já sofrem de outras desvantagens.The text presents some results of a recently concluded investigation that, generically, is part of the complex processes of the (multi) regulation of education. The study was developed in a district in the north of Portugal (conventionally designated Vila Formosa) and was limited to schools that offered secondary education. The analysis of the data suggests that, in the complex topography of the processes of (multi)regulation of the school field, the combination of measures of educational policy with resources and courses of action that the different schools and the diverse categories of families and young people possess and adopt constitute a triad of dynamic sources, sometimes convergent and sometimes tense, that, by their cumulative sociological effects, generate the re-ordination of the field of competing struggles in education that seem to penalize, above all, the families that already suffer other disadvantages.El texto presenta algunos resultados de una investigación recientemente finalizada que, genéricamente, se inscribe en los complexos procesos de (multi) regulación de la educación. El estudio se desarrolló en un consejo del norte de Portugal (asignado convencionalmente Vila Formosa), circunscribiéndose a las escuelas con oferta de enseñanza secundaria. El análisis de los datos sugiere que, en la compleja topografía de los procesos de (multi)regulación del campo escolar, la combinación de medidas de política educativa con los recursos y los cursos de acción que las diferentes escuelas y las diversas categorías de familias y jóvenes retienen y que adoptan, constituyen una tríada de fuentes de dinámicas, unas veces convergentes, otras veces en tensión que, por sus efectos sociológicos acumulativos, generan la reordenación del campo de luchas competitivas alrededor de la educación y de los resultados de esas luchas que parecen penalizar principalmente a las familias que ya sufren de otras desventajas.(undefined

MT-ND5 Mutation Exhibits Highly Variable Neurological Manifestations at Low Mutant Load.

Mutations in the m.13094T>C MT-ND5 gene have been previously described in three cases of Leigh Syndrome (LS). In this retrospective, international cohort study we identified 20 clinically affected individuals (13 families) and four asymptomatic carriers. Ten patients were deceased at the time of analysis (median age of death was 10years (range: 5·4months-37years, IQR=17·9years). Nine patients manifested with LS, one with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS), and one with Leber hereditary optic neuropathy. The remaining nine patients presented with either overlapping syndromes or isolated neurological symptoms. Mitochondrial respiratory chain activity analysis was normal in five out of ten muscle biopsies. We confirmed maternal inheritance in six families, and demonstrated marked variability in tissue segregation, and phenotypic expression at relatively low blood mutant loads. Neuropathological studies of two patients manifesting with LS/MELAS showed prominent capillary proliferation, microvacuolation and severe neuronal cell loss in the brainstem and cerebellum, with conspicuous absence of basal ganglia involvement. These findings suggest that whole mtDNA genome sequencing should be considered in patients with suspected mitochondrial disease presenting with complex neurological manifestations, which would identify over 300 known pathogenic variants including the m.13094T>C

Early efficacy of CABG care delivery in a low procedure-volume community hospital: operative and midterm results

BACKGROUND: The Leapfrog Group recommended that coronary artery bypass grafting (CABG) surgery should be done at high volume hospitals (>450 per year) without corresponding surgeon-volume criteria. The latter confounds procedure-volume effects substantially, and it is suggested that high surgeon-volume (>125 per year) rather than hospital-volume may be a more appropriate indicator of CABG quality. METHODS: We assessed 3-year isolated CABG morbidity and mortality outcomes at a low-volume hospital (LVH: 504 cases) and compared them to the corresponding Society of Thoracic Surgeons (STS) national data over the same period (2001–2003). All CABGs were performed by 5 high-volume surgeons (161–285 per year). "Best practice" care at LVH – including effective practice guidelines, protocols, data acquisition capabilities, case review process, dedicated facilities and support personnel – were closely modeled after a high-volume hospital served by the same surgeon-team. RESULTS: Operative mortality was similar for LVH and STS (OM: 2.38% vs. 2.53%), and the corresponding LVH observed-to-expected mortality (O/E = 0.81) indicated good quality relative to the STS risk model (O/E<1). Also, these results were consistent irrespective of risk category: O/E was 0, 0.9 and 1.03 for very-low risk (<1%), low risk (1–3%) and moderate-to-high risk category (>3%), respectively. Postoperative leg wound infections, ventilator hours, renal dysfunction (no dialysis), and atrial fibrillation were higher for LVH, but hospital stay was not. The unadjusted Kaplan-Meier survival for the LVH cohort was 96%, 94%, and 92% at one, two, and three years, respectively. CONCLUSION: Our results demonstrated that high quality CABG care can be achieved at LVH programs if 1) served by high volume surgeons and 2) patient care procedures similar to those of large programs are implemented. This approach may prove a useful paradigm to ensure high quality CABG care and early efficacy at low volume institutions that wish to comply with the Leapfrog standards