183 research outputs found
Systems training and development of personnel at the oil and gas companies
Training is a process of development of specific skills through special training methods. Staff training ensures professional knowledge and skills of modern production requirements. Modern business is growing, the competition grows, and as a result, organizations need to make more efforts to develop rapidly and be successful. This fact began to realize by progressive Russian oil and gas companies, which are increasingly focused on the creation of professional personnel management system. Training systems currently used by most major oil and gas companies. This allows enterprises to successfully exist in a competitive environment. The article describes the system of training and staff development. Obtained system of training in the workplace and outside it. Presents the advantages and disadvantages of systems
Design White label IPTV application for Apple TV platform
Analysis of IPTV/OTT system of βTelebreeze Corporationβ company was done and general structure of this system was reviewed. βWhite labelβ application for Apple TV was designed and his place in the βTelebreeze Corporationβ system was described
B cell activation and proliferation increase intracellular zinc levels
Zinc ions serve as second messengers in major cellular pathways, including the regulation pathways of proliferation and their proper regulation is necessary for homeostasis and a healthy organism. Accordingly, expression of zinc transporters can be altered in various cancer cell lines and is often involved in producing elevated intracellular zinc levels. In this study, human B cells were infected with EpsteinβBarr virus (EBV) to generate immortalized cells, which revealed traits of tumor cells, such as high proliferation rates and an extended lifespan. These cells showed differentially altered zinc transporter expression with ZIP7 RNA and protein expression being especially increased as well as a corresponding increased phosphorylation of ZIP7 in EBV-transformed B cells. Accordingly, free zinc levels were elevated within these cells. To prove whether the observed changes resulted from immortalization or rather high proliferation, free zinc levels in in vitro activated B cells and in freshly isolated B cells expressing the activation marker CD69 were determined. Here, comparatively increased zinc levels were found, suggesting that activation and proliferation, but not immortalization, act as crucial factors for the elevation of intracellular free zinc
Bir tΓΆvbekar
Ahmet Mithat'Δ±n TercΓΌman-Δ± Hakikat'te tefrika edilen Bir TΓΆvbekar adlΔ± roman
ΠΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΡ ΡΡΠ»ΠΎΠ²ΠΈΠΉ ΡΠΊΡΡΡΠ°Π³ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΌΠ΅Π»Π°Π½ΠΈΠ½ΠΎΠ² ΠΈΠ· Π»ΡΠ·Π³ΠΈ ΠΏΠΎΠ΄ΡΠΎΠ»Π½Π΅ΡΠ½ΠΈΠΊΠ°
ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΡΠΊΡΡΡΠ°Π³ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΌΠ΅Π»Π°Π½ΠΈΠ½ΠΎΠ² ΠΈΠ· Π»ΡΠ·Π³ΠΈ ΠΏΠΎΠ΄ΡΠΎΠ»Π½Π΅ΡΠ½ΠΈΠΊΠ°: ΡΠ°ΡΡΠΎΡΠ° Π²ΠΈΠ±ΡΠ°ΡΠΈΠΉ 24 ΠΡ, ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ ΡΠ°ΡΡΠ²ΠΎΡΠ° Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠ΄Π° Π½Π°ΡΡΠΈΡ 0,36 Π, 3 ΡΡΡΠΏΠ΅Π½ΠΈ ΡΠΊΡΡΡΠ°Π³ΠΈΡΠΎΠ²Π°Π½ΠΈΡ, ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΡΠΊΡΡΡΠ°Π³ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½Π° ΠΊΠ°ΠΆΠ΄ΠΎΠΉ ΡΡΡΠΏΠ΅Π½ΠΈ 20 ΠΌΠΈΠ½ΡΡ. ΠΡΡ
ΠΎΠ΄ ΠΌΠ΅Π»Π°Π½ΠΈΠ½ΠΎΠ² ΠΏΡΠΈ Π΄Π°Π½Π½ΡΡ
ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΡΠΎΡΡΠ°Π²ΠΈΠ» 13,09%. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ ΠΏΡΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ΅ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΠΌΠ΅Π»Π°Π½ΠΈΠ½Π° ΠΈΠ· Π°Π»ΡΡΠ΅ΡΠ½Π°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΡΡΡΡ - Π»ΡΠ·Π³ΠΈ ΠΏΠΎΠ΄ΡΠΎΠ»Π½Π΅ΡΠ½ΠΈΠΊΠ°.Defined are the optimal values of the parameters extraction of melanin from the husks of sunflower: the vibration frequency 24 Hz, the concentration of sodium hydroxide solution 0,36 M, 3 stages of extraction, duration of extraction at each stage in 20 minutes. The degree of extraction of melanin under these conditions were 13,09%. The results obtained determine the possibility of development of technology for production melanines from alternative raw materials - sunflower husk
ΠΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΡΠ΅ Π³Π΅ΠΎΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Ρ ΡΠ΅Π»ΡΡ ΠΎΡΠ΅Π½ΠΊΠΈ ΡΠ΅Ρ Π½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΡΠΊΠ²Π°ΠΆΠΈΠ½ Π½Π° Π‘Π°ΠΌΠΎΡΠ»ΠΎΡΡΠΊΠΎΠΌ Π½Π΅ΡΡΠ΅Π³Π°Π·ΠΎΠ²ΠΎΠΌ ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΠΈ (Π₯Π°Π½ΡΡ-ΠΠ°Π½ΡΠΈΠΉΡΠΊΠΈΠΉ Π°Π²ΡΠΎΠ½ΠΎΠΌΠ½ΡΠΉ ΠΎΠΊΡΡΠ³)
ΠΡΠΎΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΏΡΠΎΠΌΡΡΠ»ΠΎΠ²ΠΎ-Π³Π΅ΠΎΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π½Π° Π‘Π°ΠΌΠΎΡΠ»ΠΎΡΡΠΎΠΊΠΌ ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΠΈ Π΄Π»Ρ ΡΠΊΠ²Π°ΠΆΠΈΠ½Ρ, ΠΊΠΎΡΠΎΡΠ°Ρ Π½Π°Ρ
ΠΎΠ΄ΠΈΡΡΡ ΠΏΠΎΡΠ»Π΅ ΡΠ΅ΠΌΠΎΠ½ΡΠ°. ΠΠ°ΠΏΡΠΎΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ ΡΠ΅ΡΠ°Π΅Ρ Π·Π°Π΄Π°ΡΡ, ΠΏΡΠΎΠ²Π΅ΡΠΊΠ° ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΊΠΎΠ½Π΄ΡΠΊΡΠΎΡΠ° Π² ΠΈΠ½ΡΠ΅ΡΠ²Π°Π»Π΅ 100-250 ΠΌΠ΅ΡΡΠΎΠ².Design of a complex of trade geophysical surveys on Samotlorsokm the field for the well which is after repair. The designed complex has to solve a problem, check of technical condition of the conductor in the range of 100-250 meters
ΠΠΠ‘Π’ΠΠ‘Π£ΠΠΠΠΠ― Π Π‘Π₯ΠΠΠΠ₯ ΠΠΠΠΠΠ§ΠΠΠΠ― Π’ΠΠΠΠΠΠΠΠ ΠΠΠΠΠΠΠ Π‘ΠΠ ΠΠΠΠΠ Π£ΠΠΠ‘ΠΠΠΠΠΠΠΠΠΠ ΠΠΠΠΠΠ’ΠΠΠΠ ΠΠΠΠ ΠΠ¦ΠΠΠΠΠΠ£
ΠΡΠΎΠ±Π»Π΅ΠΌΠ° ΡΠ° ΡΡ Π·Π²'ΡΠ·ΠΎΠΊ Π· Π½Π°ΡΠΊΠΎΠ²ΠΈΠΌΠΈ Ρ ΠΏΡΠ°ΠΊΡΠΈΡΠ½ΠΈΠΌΠΈ Π·Π°Π΄Π°ΡΠ°ΠΌΠΈ. ΠΠ΅ΠΎΠ±Ρ
ΡΠ΄Π½Π° ΡΡΡΠΏΡΠ½Ρ ΠΏΠΎΠ΄ΡΡΠ±Π½Π΅Π½Π½Ρ ΡΡΠ΄ΠΈ ΠΏΠ΅ΡΠ΅Π΄ ΡΡ ΠΏΠ΅ΡΠ΅ΡΠΎΠ±Π»Π΅Π½Π½ΡΠΌ Π²ΠΈΠ·Π½Π°ΡΠ°ΡΡΡΡΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΎΠΌ Π²ΠΊΡΠ°ΠΏΠ»Π΅Π½Π½Ρ ΡΡΠ΄Π½ΠΈΡ
ΠΌΡΠ½Π΅ΡΠ°Π»ΡΠ², Π²ΠΈΠΊΠΎΡΠΈΡΡΠ°Π½Π½ΡΠΌ ΡΡΠ·Π½ΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΡΠ² Π·Π±Π°Π³Π°ΡΠ΅Π½Π½Ρ ΡΠΈΡΠΎ-Π²ΠΈΠ½ΠΈ, Π²ΠΈΠΌΠΎΠ³Π°ΠΌΠΈ Π΄ΠΎ ΡΠΊΠΎΡΡΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΡΠ², ΠΏΠΎΡΠ»ΡΠ΄ΠΎΠ²Π½ΡΡΡΡ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ², ΡΠΎ Π·Π°ΡΡΠΎΡΠΎΠ²ΡΡΡΡΡΡ Ρ ΡΡ
Π΅ΠΌΠ°Ρ
ΠΏΠ΅ΡΠ΅ΡΠΎΠ±ΠΊΠΈ ΠΊΠΎΡΠΈΡΠ½ΠΈΡ
ΠΊΠΎΠΏΠ°Π»ΠΈΠ½. Π§ΠΈΠΌ ΡΠΎΠ½ΡΠ΅ ΠΊΡΠ½ΡΠ΅Π²Π° ΠΊΡΡΠΏΠ½ΡΡΡΡ ΠΏΠΎΠ΄ΡΡΠ±Π½Π΅Π½Π½Ρ ΡΡΠ΄ΠΈ, ΡΠΈΠΌ ΠΌΠ΅Π½ΡΠ΅ Π·Π°Π»ΠΈΡΠ°ΡΡΡΡΡ ΠΌΡΠ½Π΅ΡΠ°Π»ΡΠ½ΠΈΡ
Π·ΡΠΎΡΡΠΊΡΠ² Ρ ΡΠΈΠΌ Π±ΡΠ»ΡΡΠ΅ Π²ΡΡΠΎΠ³ΡΠ΄Π½ΡΡΡΡ ΠΎΡΡΠΈΠΌΠ°Π½Π½Ρ ΡΠΊΡΡΠ½ΠΈΡ
ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΡΠ²
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ°ΡΠ°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΌΠ΅ΡΠ°Π»Π»ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΠΎΡΠΎΡΠΊΠΎΠ², ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ ΡΠ»Π΅ΠΊΡΡΠΎΠΈΠΌΠΏΡΡΠ½ΡΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ, Π² ΡΠΈΠ½ΡΠ΅Π·Π΅ Π€ΠΈΡΠ΅ΡΠ° Π’ΡΠΎΠΏΡΠ°
Π ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΊΠ°ΡΠ°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΌΠ΅ΡΠ°Π»Π»ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΡΠΎΡΠΊΠΎΠ² ΠΠ6 ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΡ
Π² ΡΠΎΠ»ΠΈ ΠΊΠ°ΡΠ°Π»ΠΈΠ·Π°ΡΠΎΡΠ° Π² ΡΠΈΠ½ΡΠ΅Π·Π΅ Π€ΠΈΡΠ΅ΡΠ°-Π’ΡΠΎΠΏΡΠ°. ΠΡΠΏΡΡΠ°Π½ΠΈΡ Π±ΡΠ»ΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Ρ Π½Π° Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎΠΉ ΡΡΡΠ°Π½ΠΎΠ²ΠΊΠ΅, ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΠΎΠΉ ΠΈ ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½Π½ΠΎΠΉ ΠΠΠ Β«ΠΠ°ΡΠ°ΠΊΠΎΠ½Β», Π³.ΠΠΎΠ²ΠΎΡΠΈΠ±ΠΈΡΡΠΊ. ΠΠ»Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΡΠΎΠ½ΠΊΠΎΠ΄ΠΈΡΠΏΠ΅ΡΡΠ½ΡΡ
ΠΏΠΎΡΠΎΡΠΊΠΎΠ² ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΡΡ ΠΌΠ΅ΡΠΎΠ΄ ΡΠ»Π΅ΠΊΡΡΠΎΠΈΡΠΊΡΠΎΠ²ΠΎΠ³ΠΎ Π΄ΠΈΡΠΏΠ΅ΡΠ³ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π² ΠΆΠΈΠ΄ΠΊΠΎΠΉ ΡΡΠ΅Π΄Π΅. ΠΠ»Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΏΠΎΡΠΎΡΠΊΠΎΠ² ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈΡΡ: ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π²Π΅Π»ΠΈΡΠΈΠ½Ρ ΡΠ΄Π΅Π»ΡΠ½ΠΎΠΉ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ ΡΠ°ΡΡΠΈΡ ΠΏΠΎΡΠΎΡΠΊΠΎΠ² ΠΏΠΎ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΠΠ’, ΠΌΠ΅ΡΠΎΠ΄Ρ ΡΠ°ΡΡΡΠΎΠ²ΠΎΠΉ ΠΈ ΡΠΊΠ°Π½ΠΈΡΡΡΡΠ΅ΠΉ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΡΠ°Π·ΠΎΠ²ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π°.The research effort presents the results of a studing catalytic activity of metal powders VK6 used as catalyst in the synthesis of Fischer-Tropsch. Tests were conducted on a laboratory installation, which was designed and manufactured by CJSC "Caticon", Novosibirsk. The method of electrospark dispersion in liquid medium was applied during obtaining a fine powder. To study the physico-chemical properties of the obtained powders were used for determination of the specific surface of particles of powders by BET method, methods of raster and scanning electron microscopy, and X-ray phase analysis
S-thioallylation of proteins by the garlic defence substance allicin and its biological effects
A single clove of edible garlic (Allium sativum L.) of about 10β―g produces up to 5β―mg of allicin (diallylthiosulfinate), a thiol-reactive sulfur-containing defence substance that gives injured garlic tissue its characteristic smell. Allicin induces apoptosis or necrosis in a dose-dependent manner but biocompatible doses influence cellular metabolism and signalling cascades. Oxidation of protein thiols and depletion of the glutathione pool are thought to be responsible for allicin's physiological effects. Here, we studied the effect of allicin on post-translational thiol-modification in human Jurkat T-cells using shotgun LC-MS/MS analyses. We identified 332 proteins that were modified by S-thioallylation in the Jurkat cell proteome which causes a mass shift of 72β―Da on cysteines. Many S-thioallylated proteins are highly abundant proteins, including cytoskeletal proteins tubulin, actin, cofilin, filamin and plastin-2, the heat shock chaperones HSP90 and HSPA4, the glycolytic enzymes GAPDH, ALDOA, PKM as well the protein translation factor EEF2. Allicin disrupted the actin cytoskeleton in murine L929 fibroblasts. Allicin stimulated the immune response by causing Zn2+ release from proteins and increasing the Zn2+-dependent IL-1-triggered production of IL-2 in murine EL-4 T-cells. Furthermore, allicin caused inhibition of enolase activity, an enzyme considered a cancer therapy target. In conclusion, our study revealed the widespread extent of S-thioallylation in the human Jurkat cell proteome and showed effects of allicin exposure on essential cellular functions of selected targets, many of which are targets for cancer therapy
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