Oxidation products of DNA, lipid and protein among the individuals progressing towards metabolic syndrome

Oxidative stress (OS) is an early event and at the same time also a consequence in the pathology of MetS. We investigated if oxidation markers of DNA, lipid and protein increased with an increase in the risk parameters of MetS. Participants (male:70, female:90 ≥ 20 yrs) were categorized based on the number of risk factors they had as 3 Risk, 2 Risk, 1 Risk and 0 Risk for MetS and were evaluated for various oxidation markers. Protein carbonyl and advanced oxidation protein product (protein oxidation marker) differed significantly between the four study group while malondialdehyde and hydroxynonenal (lipid peroxidation marker) did not. “8-OH dG” (DNA oxidation marker) differed significantly (P< 0.05) while total antioxidant capacity did not demonstrate significant difference in its values across the group (P> 0.05). Pairwise comparison for statistically significant markers(Protein oxidation markers and 8-OH dG), demonstrated that only 8-OH dG differed significantly between 0 Risk- 3 Risk (P< 0.012) but not between 0 Risk -2 Risk and 0 Risk-1 Risk. Oxidative stress markers of DNA, lipid and protein do not increase with an increase in the risk parameters of MetS. However, it is indeed high in MetS with 3 and more risk parameters. Presence of 2 or 1 Risk also increases OS compared to 0 Risk. There is oxidative stress damage in MetS to lipid and protein but DNA damage was of significant consequence

Gender authorship trends in spine research publications - Research across different countries from 1976 to 2020.

•Gender trends in authorship showed an increase in female authors from 1976 to 2020.•In 2020, Europe had the highest and Asia the lowest proportion of female authors.•The Netherlands had the highest proportion of women and Japan the lowest

Productivity of mixtures and evolutionary populations of wheat, barley, beans and rice

Mixtures of different varieties of barley (Hordeum vulgare), wheat (Triticum ssp.) are grown by farmers in Ethiopia, Iran, Jordan, as a means of diversifying production and/or coping with difficult or uncertain growing conditions. Similarly, mixtures of different varieties of beans (Phaseolus vulgaris) were grown by farmers in Bhutan, Nepal and Uganda, with mixtures of Rice (Oryza sativa) were also grown by Bhutan and Nepal farmers. The mixture of all crops in all countries were grown for three consecutive years under IFAD – EPB project. Varietal diversity can improve farmers’ productivity, capabilities to manage pests and diseases and allows farmers to select suitable cultivars in response to varied or uncertain climatic conditions. Moreover, varietal diversification can improve the nutritional security of smallholder farmers

Oxidation products of DNA, lipid and protein among the individuals progressing towards metabolic syndrome

155-161Oxidative stress (OS) is an early event and at the same time also a consequence in the pathology of MetS. We investigated if oxidation markers of DNA, lipid and protein increased with an increase in the risk parameters of MetS. Participants (male:70, female:90 ≥ 20 yrs) were categorized based on the number of risk factors they had as 3 Risk, 2 Risk, 1 Risk and 0 Risk for MetS and were evaluated for various oxidation markers. Protein carbonyl and advanced oxidation protein product (protein oxidation marker) differed significantly between the four study group while malondialdehyde and hydroxynonenal (lipid peroxidation marker) did not. “8-OH dG” (DNA oxidation marker) differed significantly (PP> 0.05). Pairwise comparison for statistically significant markers(Protein oxidation markers and 8-OH dG), demonstrated that only 8-OH dG differed significantly between 0 Risk- 3 Risk (P< 0.012) but not between 0 Risk -2 Risk and 0 Risk-1 Risk. Oxidative stress markers of DNA, lipid and protein do not increase with an increase in the risk parameters of MetS. However, it is indeed high in MetS with 3 and more risk parameters. Presence of 2 or 1 Risk also increases OS compared to 0 Risk. There is oxidative stress damage in MetS to lipid and protein but DNA damage was of significant consequence. </span

Asia Now Surpasses Europe in Spine Research Productivity : An Analysis from 1976-2020

Study Design. Bibliometric Review Objective. This study aims to understand the worldwide research productivity trends in spine-related research over the past five decades. Summary of Background Data. ?? ??? Methods. We evaluated original research articles published in four prestigious journals on spine research (European Spine Journal, Journal of Neurosurgery: Spine, Spine, and The Spine Journal) from 1976 to 2020. For one year of each decade, the origin of the first and the senior author was assigned to their region of origin. For the year 2020, a detailed analysis of countries and states of origin was performed, and the number of articles was normalized by registered MDs per country (per 10,000 population). Results. We included a total of 4,436 articles and 8,776 authors for analysis. From 1976 to 2020, the percentage of publications originating from North America decreased (77% – 38%). In contrast, Asian contributions drastically increased (3% – 36%), whereas articles originating from Europe only slightly raised (20% – 22%). In 2020, the USA was the most productive country worldwide (34% with most articles from New York (19%), followed by China (16%) and Japan (10%). After normalization to registered MDs (per 10,000 population), the USA proved to have the highest number of articles. Besides this, India now ranked fourth and Egypt eighth in terms of the most productive countries per MDs. Conclusion. North America contributed the largest share of all articles published in the last five decades. Asia, which ranks second in 2020, has overtaken Europe. Normalization to registered MDs can be a helpful tool to reflect a country's research productivity more accurately. Level of Evidence: