New insular taxa from the oldest Terre Rosse fissure filling (Gargano, Southeastern Italy).

A rich amount of fossil remains of a highly diversified vertebrate fauna, known as “Mikrotia fauna”, has been retrieved from the red soil deposits (Terre Rosse) which fill the extensive palaeokarst network that affects the Mesozoic limestone along the north-western slopes of Mount Gargano (Southern Italy). The faunal assemblages reveal a rather complex history of bioevents such as dispersals and extinctions, which occurred when the area was isolated. These reconstructions were based on the materials collected during the seventies and the eighties of the last century. Forty years after its discovery, the Gargano Terre Rosse finally yielded evidence of an older faunal settlement. The peculiar assemblage of the M013 fissure allows to explain some of the controversial aspects of the Gargano faunal history, namely, the matter of the biochronology of the older fissure fillings and the issue of the arrivals of the taxa in the insular domain. The taxonomic study of the small mammal assemblage from fissure M013, sampled by a team of the University of Torino during the 2005-09 excavations in the Dell’Erba Quarry (Apricena, Foggia), is here presented. Insectivores include a small-sized endemic Galericinae Apulogalerix cf. pusillus, together with a Crocidosoricinae, Lartetium cf. dehmi. Gliridae are well represented by the endemic species Stertomys simplex and S.lyrifer. Cricetids (l.s.) are represented by a single remain belonging to the endemic Hattomys cf. nazarii, but also by a new genus and species of an endemic and rather primitive Cricetodontinae. The latter shows a very hypsodont dental crown, stocky cusps and tubercle-like crests. Some of its features are typical of the continental genera of Cricetodontinae (i.e. large size, thick and crenulated enamel), however the very large size and the very high hypsodonty indicate the endemic nature of this taxon. The occlusal pattern appears rather primitive due to the very low, poorly developed, interrupted ectolophs and share some features with the primitive species of the genus Cricetodon. Murids include Mikrotia parva together with a second larger species, which is not yet identified. A third Murinae rodent is quite abundant, and belongs to a new genus and species. Its dentition is more brachyodont than in Mikrotia parva, the upper teeth are stephanodont and, accordingly, the transversal crests are joined by a longitudinal crest in the lower molars. Tubercle t7 is absent in the upper molars, t2bis is always present, while t1bis is usually absent in the first upper molar. Tubercle t1 is placed in a distal position respect to the t3, the posterolabial tubercle t12 is well-developed. Tubercles t3, t6 and t9 are roughly equidistant forming a regular pattern: a character that is found in Mikrotia and not in the other murid species, in which t6 is closer to t9. This morphological characters reveal a close relationship with Mikrotia, but they do not occur jointly in any of the Late Miocene-Earliest Pliocene European genera of murids, thus the phylogenetic origin of this new genus is still unclear. The occurrence of this new Murinae and of a Cricetodontinae distinguishes M013 from all the other Terre Rosse fissure fillings of Gargano. Stertomys lyrifer and S. simplex were previously known only from the very ancient fissure Rinascita 1. Because both taxa characterize M013 and Rinascita 1, the two fissures are believed to be very close chronologically. Also the Crocidosoricinae characterises the older fissure fillings. In contrast, M013 is the only fissure lacking Apodemus and Prolagus, which are otherwise present in all the other Gargano infillings. The accumulated evidence indicates M013 as the oldest of Gargano’s faunal assemblages, despite the occurrence of Hattomys cf. nazarii, Mikrotia cf. parva and Mikrotia sp1, which most probably results from infiltrations from younger fissure fillings. The M013 assemblage is an absolute novelty for the Abruzzo-Apulian Palaeobioprovince and opens a new perspectives for the timing and mode of dispersal of the forerunners of the Gargano fauna

Phylogenetic relationships of genus Stertomys (Gliridae) from the “Terre Rosse” fissure filling (Gargano, Apulia)

Stertomys is an endemic genus of Gliridae commonly found in the Late Miocene “Terre Rosse” fissure fillings from Gargano (southern Italy). The taxonomy of this genus have been recently reconsidered and, up to date, five new species have been described beside the giant Stertomys laticrestatus Daams & Freudenthal 1985. The species have different biochronological range and may be assigned to two groups according to their size and complexity of the dental pattern. The smaller and morphologically simpler group includes Stertomys simplex Martín-Suárez & Freudenthal 2007, Stertomys daamsi Freudenthal & Martín-Suárez 2006 (occurring in the older fissures) and Stertomys degiulii Rinaldi & Masini 2009, while the larger and more complex one takes Stertomys lyrifer Martín-Suárez & Freudenthal 2007, Stertomys daunius Freudenthal & Martín-Suárez 2006 (occurring in the older fissures) and S. laticrestatus. These two informal groups have been considered also as representing two distinct phylogenetic branches deriving from a common ancestor. Phylogenetic relationships among those species and their possible continental ancestor, however, have never been investigated in detail. In this contribution we presents the results of a parsimony phylogenetic analysis performed using PAUP software. The six Stertomys species have been considered together with several other related glirid taxa, distributed over a rather wide geographical and stratigraphical range, with the aim to verify if Stertomys is a monophyletic taxon and to identify its possible relationships with continental taxa, thus bringing some new contribution to the still open question. of the ancestry of this endemic taxon

A Scoping Review of Populist Radical Right Parties' Influence on Welfare Policy and its Implications for Population Health in Europe.

BACKGROUND: In light of worrying public health developments such as declining life expectancy gains and increasing health inequalities, there is a heightened interest in the relationship between politics and health. This scoping review explores the possible welfare policy consequences of populist radical right (PRR) parties in Europe and the implications for population health. The aim is to map the available empirical evidence regarding the influence of PRR parties on welfare policy reforms and to understand how this relationship is mediated by political system characteristics in different countries. METHODS AND ANALYSIS: A scoping review of peer-reviewed empirical literature addressing the relationship between PRR parties, political systems and welfare policy in Europe was performed using the methodology by the Joanna Briggs Institute. Data was charted on main study characteristics, concepts and relevant results, after which a qualitative content analysis was performed. The data was categorised according to the political system characteristics: constitution, political economy, interest representation and partisanship. Five expert interviews were conducted for validation purposes. Early evidence from 15 peer-reviewed articles suggests that exclusionary welfare chauvinistic positions of PRR parties are likely to have negative effects on the access to welfare provisions and health of vulnerable population groups. Differences in implementation of welfare chauvinistic policy reforms are partly explained by mediation of the constitutional order (judicial institutions at national and European Union [EU] level), political economy (healthcare system funding and European single market) and partisanship (vote-seeking strategies by PRR and mainstream parties). No clear evidence was found regarding the influence of interest representation on welfare chauvinistic policies. DISCUSSION: While early evidence suggests that the welfare chauvinistic ideology of PRR parties is harmful for public health, the possible mediating role of political system characteristics on PRR welfare policy influence offers risk and protective factors explaining why the PRR ideology plays out differently across Europe

Bridging the Gap Between Public Health and Political Science to Study the Populist Radical Right in its Multiple Manifestations: A Response to Recent Commentaries.

</jats:p

A new small mammal assemblage from the Pirro 12 “Terre Rosse” fissure filling (Gargano, Southeastern Italy).

The Pirro 12 fissure filling has been discovered and sampled by a team of the University of Torino during the 2005 field survey in the Dell’Erba Quarry (Apricena, Foggia). The occurrence of a very small Deinogalerix and of a very simple Mikrotia supported, at a first glance, the very old position of Pirro 12 in the biochronological succession of endemic faunal settlements of Gargano (Villier, 2011). In this communication the preliminary result of taxonomic studies of the small mammal assemblage of the Pirro 12 filling is presented. The Gliridae is by far the most common family in this site. Two species of the endemic genus Stertomys have been identified: the small-sized Stertomys cf simplex, and the larger-sized Stertomys cf lyrifer. The possible occurrence of Stertomy daamsi still needs to be ascertained. These Myomiminae closely resemble those of fissure Rinascita 1 reported in the literature. Murids are represented by two species of Mikrotia: one is very small, with very brachyodont crown and simple morphology of M/1, while the other is somewhat larger and hyspsodont, and has a slightly more complex occlusal pattern. Another Murinae species is rather common and although it is still being analyzed, it is the first new taxon reported from Pirro 12. A second one is a very large-sized and rather hypsodont cricetid (latu sensu) genus, which cannot be associated with any other cricetid so far reported from the Gargano Terre Rosse. Insectivores are represented by three mandibles without teeth of a small-sized Galericinae, as well as by a single remain of Crocidurinae. The sample is rather poor, and therefore the absence of characterizing taxa should be considered with caution. The occurrence of a new murine and of a new large cricetid distinguishes the Pirro 12 assemblages from all other fissure fillings. The shrew is present also in some old fissure fillings reported in the literature of the 1980’s (Martín-Suárez & Freudenthal, 2007). Stertomys lyrifer and S. symplex are found only in the fissure Rinascita 1, which is the second oldest fissure mentioned in the literature of the late 1970’s (De Giuli et al., 1987). The absence of Apodemus and Prolagus, two genera which are virtually present in all known fissure fillings from the Gargano, the absence of Hattomys, the endemic resident cricetidae, the absence of Apocricetus, Neocricetodon and Democriceton which are instead found in older fissures (i.e., Rinascita 1 and Biancone), together with the extreme primitiveness of Microtia, prove the ancient biochronological age of this fissure, changing the scenario of the oldest faunal settlements of the Abruzzo- Apulian paleo-bioprovince

Bovine Lactoferrin Prevents Invasive Fungal Infections in Very Low Birth Weight Infants: A Randomized Controlled Trial.

BACKGROUND: Lactoferrin is a mammalian milk glycoprotein involved in innate immunity. Recent data show that bovine lactoferrin (bLF) prevents late-onset sepsis in preterm very low birth weight (VLBW) neonates. METHODS: This is a secondary analysis of data from a multicenter randomized controlled trial where preterm VLBW neonates randomly received bLF (100 mg/day; group A1), bLF + Lactobacillus rhamnosus GG (10(6) colony-forming units per day; group A2), or placebo (group B) for 6 weeks. Here we analyze the incidence rates of fungal colonization, invasive fungal infection (IFI), and rate of progression from colonization to infection in all groups. RESULTS: This study included 472 neonates whose clinical, nutritional, and demographical characteristics were similar. Overall, the incidence of fungal colonization was comparable (17.6%, 16.6%, and 18.5% in A1, A2, and B, respectively; P = .89 [A1] and .77 [A2]). In contrast, IFIs were significantly decreased in A1 and A2 (0.7% and 2.0%, respectively) compared with B (7.7%; P = .002 [A1] and .02 [A2]), and this was significantly true both in <1000 g (0.9% [A1] and 5.6% [A2], vs 15.0%) and in 1001 to 1500 g infants (0% and 0% vs 3.7%). The progression rate colonization-infection was significantly lower in the bLF groups: 3.7% (A1) and 12% (A2), vs 41.9%; P < .001 (A1) and P = .02 (A2). No IFI-attributable deaths occurred in the treatment groups, versus 2 in placebo. No adverse effects or intolerances occurred. CONCLUSIONS: Prophylactic oral administration of bLF reduces the incidence of IFI in preterm VLBW neonates. No effect is seen on colonization. The protective effect on IFI is likely due to limitation of ability of fungal colonies to progress toward invasion and systemic disease in colonized infants

Predictors of orphan drug approval in the European Union

Objective: To encourage the development of drugs for rare diseases, orphan drug legislation has been introduced in the USA (1983) and in the EU (2000). Recent literature discusses factors that may influence the development of new orphan medicinal products in the EU. This study aims to identify predictors for successful marketing authorisation of potential orphan drugs in the EU. Methods: A comparison between randomly selected authorised and a matched sample of not-yet-authorised orphan drug designations has been performed. Determinants in the study included characteristics of the indication, of the product and of the sponsor. Data were collected from the public domain only. Results: Orphan drug approval was strongly associated with previous experience of the sponsor in obtaining approval for another orphan drug (OR=17.3, 95% CI=5.6-53.1). Furthermore, existing synthetic entities compared to biotechnology products tended to have a higher likelihood of reaching approval status (OR=3.9, 95% CI=0.9-16.6). Conclusion: This study showed that experience of a company in developing orphan drugs is an important predictor for subsequent authorisation of other orphan drugs. The same applies for existing (synthetic) molecules, for which much knowledge is available. Further research should be directed towards studying the quality of the clinical development program of those designated orphan medicinal products not reaching approval status

Gestational Valproate Alters BOLD Activation in Response to Complex Social and Primary Sensory Stimuli

Valproic acid (VPA) has been used clinically as an anticonvulsant medication during pregnancy; however, it poses a neurodevelopmental risk due to its high teratogenicity. We hypothesized that midgestational (GD) exposure to VPA will lead to lasting deficits in social behavior and the processing of social stimuli. To test this, animals were given a single IP injection of 600 mg/kg of VPA on GD 12.5. Starting on postnatal day 2 (PND2), animals were examined for physical and behavior abnormalities. Functional MRI studies were carried out after PND60. VPA and control animals were given vehicle or a central infusion of a V1a antagonist 90 minutes before imaging. During imaging sessions, rats were presented with a juvenile test male followed by a primary visual stimulus (2 Hz pulsed light) to examine the effects of prenatal VPA on neural processing. VPA rats showed greater increases in BOLD signal response to the social stimulus compared to controls in the temporal cortex, thalamus, midbrain and the hypothalamus. Blocking the V1a receptor reduced the BOLD response in VPA animals only. Neural responses to the visual stimulus, however, were lower in VPA animals. Blockade with the V1a antagonist did not revert this latter effect. Our data suggest that prenatal VPA affects the processing of social stimuli and perhaps social memory, partly through a mechanism that may involve vasopressin V1a neurotransmission

Clinical outcome of skin yaws lesions after treatment with benzathinebenzylpenicillin in a pygmy population in Lobaye, Central African Republic

<p>Abstract</p> <p>Background</p> <p>Yaws is a bacterial skin and bone infectious disease caused by <it>Treponema pallidum pertenue</it>. It is endemic, particularly among pygmies in Central African Republic. To assess the clinical cure rate after treatment with benzathinepenicillin in this population, we conducted a cohort survey of 243 patients in the Lobaye region.</p> <p>Findings and conclusion</p> <p>The rate of healing of lesions after 5 months was 95.9%. This relatively satisfactory level of therapeutic response implies that yaws could be controlled in the Central African Republic. Thus, reinforcement of the management of new cases and of contacts is suggested.</p

Altering the trajectory of early postnatal cortical development can lead to structural and behavioural features of autism

<p>Abstract</p> <p>Background</p> <p>Autism is a behaviourally defined neurodevelopmental disorder with unknown etiology. Recent studies in autistic children consistently point to neuropathological and functional abnormalities in the temporal association cortex (TeA) and its associated structures. It has been proposed that the trajectory of postnatal development in these regions may undergo accelerated maturational alterations that predominantly affect sensory recognition and social interaction. Indeed, the temporal association regions that are important for sensory recognition and social interaction are one of the last regions to mature suggesting a potential vulnerability to early maturation. However, direct evaluation of the emerging hypothesis that an altered time course of early postnatal development can lead to an ASD phenotype remains lacking.</p> <p>Results</p> <p>We used electrophysiological, histological, and behavioural techniques to investigate if the known neuronal maturational promoter valproate, similar to that in culture systems, can influence the normal developmental trajectory of TeA <it>in vivo</it>. Brain sections obtained from postnatal rat pups treated with VPA <it>in vivo </it>revealed that almost 40% of cortical cells in TeA prematurely exhibited adult-like intrinsic electrophysiological properties and that this was often associated with gross cortical hypertrophy and a reduced predisposition for social play behaviour.</p> <p>Conclusions</p> <p>The co-manifestation of these functional, structural and behavioural features suggests that alteration of the developmental time course in certain high-order cortical networks may play an important role in the neurophysiological basis of autism.</p