816 research outputs found

    Brain-derived neurotrophic factor association with amygdala response in major depressive disorder

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    Background: Brain-derived neurotrophic factor (BDNF) has an essential role in synaptic plasticity and neurogenesis. BDNF mediates amygdala-dependent learning for both aversive and appetitive emotional memories. The expression of BDNF in limbic regions is posited to contribute the development of depression, and amygdala responsivity is a potential marker of depressive state. Methods: The present study examined the relationship between platelet BDNF levels and amygdala volume and function in major depressive disorder (MDD). Participants were 23 MDD (mean age 38.9 years) and 23 healthy controls (mean age 38.8 years). All participants were recruited from the community. MDD participants were in a current depressive episode of moderate severity and medication-free. Amygdala responses were acquired during a functional MRI task of implicit emotional processing with sad facial expressions. Results: Significant correlation was observed between platelet BDNF levels and left amygdala responses, but no significant correlations were found with right amygdala responses or with amygdala volumes. Limitations: Interactions with neuroprotective as well as neurotoxic metabolites in the kyneurenine pathway were not examined. Conclusions: Relationship between BDNF levels and amygdala responsivity to emotionally salient stimuli in MDD could reflect the importance of BDNF in amygdala-dependent learning with clinical implications for potential pathways for treatment

    A spectral survey of an ultra-hot Jupiter: Detection of metals in the transmission spectrum of KELT-9 b

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    Context: KELT-9 b exemplifies a newly emerging class of short-period gaseous exoplanets that tend to orbit hot, early type stars - termed ultra-hot Jupiters. The severe stellar irradiation heats their atmospheres to temperatures of 4,000\sim 4,000 K, similar to the photospheres of dwarf stars. Due to the absence of aerosols and complex molecular chemistry at such temperatures, these planets offer the potential of detailed chemical characterisation through transit and day-side spectroscopy. Studies of their chemical inventories may provide crucial constraints on their formation process and evolution history. Aims: To search the optical transmission spectrum of KELT-9 b for absorption lines by metals using the cross-correlation technique. Methods: We analyse 2 transits observed with the HARPS-N spectrograph. We use an isothermal equilibrium chemistry model to predict the transmission spectrum for each of the neutral and singly-ionized atoms with atomic numbers between 3 and 78. Of these, we identify the elements that are expected to have spectral lines in the visible wavelength range and use those as cross-correlation templates. Results: We detect absorption of Na I, Cr II, Sc II and Y II, and confirm previous detections of Mg I, Fe I, Fe II and Ti II. In addition, we find evidence of Ca I, Cr I, Co I, and Sr II that will require further observations to verify. The detected absorption lines are significantly deeper than model predictions, suggesting that material is transported to higher altitudes where the density is enhanced compared to a hydrostatic profile. There appears to be no significant blue-shift of the absorption spectrum due to a net day-to-night side wind. In particular, the strong Fe II feature is shifted by 0.18±0.270.18 \pm 0.27 km~s1^{-1}, consistent with zero. Using the orbital velocity of the planet we revise the steller and planetary masses and radii.Comment: Submitted to Astronomy and Astrophysics on January 18, 2019. Accepted on May 3, 2019. 26 pages, 11 figure

    Technological Devices in the Archives: A Policy Analysis

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    Doing research in the archive is the cornerstone of humanities scholarship. Various archives institute policies regarding the use of technological devices, such as mobile phones, laptops, and cameras in their reading rooms. Such policies directly affect the scholars as the devices mediate the nature of their interaction with the source materials in terms of capturing, organizing, note taking, and record keeping for future use of found materials. In this paper, we present our analysis of the policies of thirty archives regarding the use of technology in their reading rooms. This policy analysis, along with data from interviews of scholars and archivists, is intended to serve as a basis for developing mobile applications for assisting scholars in their research activities. In this paper we introduce an early prototype of such a mobile application— AMTracker.Informatio

    Home sweet home: a critical comment on Saunders and Williams

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    While accepting the need for research which focuses on the social meaning of the home, this article takes issue with some of Saunders’ and Williams’ formulations for a research programme — in particular, the emphasis given to physical and design features of the home at the expense of an understanding of more fundamental gender and generational relations within the home. It attempts to uncover the assumptions lying behind those formulations, to clarify some of the conceptual confusions, and to point out some of the serious theoretical difficulties which such formulations have to resolve. It argues that theoretical advance in this area does not have to depend upon the adoption of a Weberian perspective, but must be situated within a broader theory of the production and maintenance of ideology, and this theory must be explicitly linked with theories of power and kinship. In particular, it is emphasised that power relations within the home, associated mainly with gender and age differences, need to be investigated in greater depth if the social significance of the home is to be properly understood

    Linear stability in billiards with potential

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    A general formula for the linearized Poincar\'e map of a billiard with a potential is derived. The stability of periodic orbits is given by the trace of a product of matrices describing the piecewise free motion between reflections and the contributions from the reflections alone. For the case without potential this gives well known formulas. Four billiards with potentials for which the free motion is integrable are treated as examples: The linear gravitational potential, the constant magnetic field, the harmonic potential, and a billiard in a rotating frame of reference, imitating the restricted three body problem. The linear stability of periodic orbits with period one and two is analyzed with the help of stability diagrams, showing the essential parameter dependence of the residue of the periodic orbits for these examples.Comment: 22 pages, LaTex, 4 Figure

    Accelerated BEP : a phase I trial of dose-dense BEP for intermediate and poor prognosis metastatic germ cell tumour

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    Background: We used bleomycin, etoposide, cisplatin (BEP), the most effective regimen in the treatment of germ cell tumours (GCTs) and increased dose-density by using pegfilgrastim to shorten cycle length. Our aim was to assess safety and tolerability. Methods: Sixteen male patients with intermediate or poor prognosis metastatic GCT were treated with four cycles of 3-day BEP with G-CSF on a 14-day cycle for a planned relative dose-density of 1.5 compared with standard BEP. Results: Eleven intermediate and five poor prognosis patients were treated. In all, 14 of 16 patients completed the study treatment. Toxicities were comparable to previous studies using standard BEP, except for mucositis and haematological toxicity that were more severe. The overall relative dose-density for all 16 patients was mean 1.38 (range 0.72–1.5; median 1.46). Complete response was achieved after chemotherapy alone in two patients (13%) and following chemotherapy plus surgery in nine additional patients (56%). Four patients (25%) had a partial response and normalised their marker levels. At a median follow-up of 4.4 years (range 2.1–6.8) the estimated 5-year progression-free survival probability is 81% (95% CI 64–100%). Conclusion: Accelerated BEP is tolerable without major additional toxicity. A randomised controlled trial will be required to obtain comparative efficacy data
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