連続変位観測記録から見たフィリピン・マニラ首都圏にあるマリキナ断層のクリープ性状

Continuous monitoring of the fault creep along the Western Marikina Valley Fault System (MarikinaFault), in the southern part of Metro Manila, Philippines, was started from Sep. 2008. Although the dataobtained includes daily fluctuation due to thermal deformation of the metal used to fix equipment, the totalmovement obtained by this monitoring and that of repeated leveling survey show similar amounts. Theaverage slip late by this continuous monitoring is about 0.01mm/day form Sep. 14, 2008 to Jan 16, 2009. Butno movement has been detected during Jan. 16 and July 7, 2009. Further monitoring is necessary to clearlythe characteristics of the creep

Data Collection Challenges and Recommendations for Early Career Researchers

Data collection is critical to the social research process. When implemented correctly, data collection enhances the quality of a social research study. However, doctoral students and early career researchers may encounter challenges with data collection. This article reports on the data collection challenges in dissertation research encountered by doctoral students enrolled in a public health program at a southeastern United States urban university. Each doctoral student shared at least one challenge and how it affected the data collection process. Additionally, the doctoral students shared how the identified challenges were addressed or suggested recommendations. Understanding these experiences of doctoral students is helpful for doctoral students and early career researchers conducting social research. The lessons learned may guide faculty in research mentoring and structuring research seminars for doctoral students

Recruitment in Qualitative Public Health Research: Lessons Learned During Dissertation Sample Recruitment

The purpose of this article is to describe the recruitment challenges faced by eight public health graduate students when conducting qualitative dissertation research. The authors summarize their dissertation studies, describe recruitment challenges, and provide strategies and recommendations used to address challenges. The authors identified twelve recruitment issues which they grouped into three major categories: (a) obtaining consent; (b) working with gatekeepers; and (c) accessing participants. The authors propose three recommendations to consider in participant recruitment, which are: (a) collaborate with gatekeepers; (b) use additional recruitment tools; and (c) understand your target population. The compilation of experiences from multiple graduate students from a diverse selection of topics provides valuable insight and resources when planning a qualitative research study in the field of public health

Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol

<p>Abstract</p> <p>Background</p> <p>Pterostilbene, a naturally occurring phenolic compound produced by agronomically important plant genera such as <it>Vitis </it>and <it>Vacciunium</it>, is a phytoalexin exhibiting potent antifungal activity. Additionally, recent studies have demonstrated several important pharmacological properties associated with pterostilbene. Despite this, a systematic study of the effects of pterostilbene on eukaryotic cells at the molecular level has not been previously reported. Thus, the aim of the present study was to identify the cellular pathways affected by pterostilbene by performing transcript profiling studies, employing the model yeast <it>Saccharomyces cerevisiae</it>.</p> <p>Methods</p> <p><it>S. cerevisiae </it>strain S288C was exposed to pterostilbene at the IC₅₀concentration (70 μM) for one generation (3 h). Transcript profiling experiments were performed on three biological replicate samples using the Affymetrix GeneChip Yeast Genome S98 Array. The data were analyzed using the statistical methods available in the GeneSifter microarray data analysis system. To validate the results, eleven differentially expressed genes were further examined by quantitative real-time RT-PCR, and <it>S. cerevisiae </it>mutant strains with deletions in these genes were analyzed for altered sensitivity to pterostilbene.</p> <p>Results</p> <p>Transcript profiling studies revealed that pterostilbene exposure significantly down-regulated the expression of genes involved in methionine metabolism, while the expression of genes involved in mitochondrial functions, drug detoxification, and transcription factor activity were significantly up-regulated. Additional analyses revealed that a large number of genes involved in lipid metabolism were also affected by pterostilbene treatment.</p> <p>Conclusion</p> <p>Using transcript profiling, we have identified the cellular pathways targeted by pterostilbene, an analog of resveratrol. The observed response in lipid metabolism genes is consistent with its known hypolipidemic properties, and the induction of mitochondrial genes is consistent with its demonstrated role in apoptosis in human cancer cell lines. Furthermore, our data show that pterostilbene has a significant effect on methionine metabolism, a previously unreported effect for this compound.</p

Perception of Filipino physicians on the roles and scope of practice of physical therapy in the Philippines: A multi-method quantitative study

Introduction: Physical therapists (PTs) are licensed practitioners who can assess, diagnose, and provide treatment interventions that restore patients to optimal function. While PTs can deliver complete management plans, the practice of physical therapy (PT) in the Philippines follows a referral system where physicians are the first contact of the patient, emphasizing the importance of physician\u27s perception towards the role of PTs and scope of PT service. This study aimed to determine the internal consistency of the Perception on Physical Therapists Questionnaire (PoPTQ), and to use this tool to report the existing perceptions of Filipino physicians on the practice of PT. Method: This study was divided into two phases and utilized a multi-method quantitative research design. For Phase 1 (psychometric), 18 questionnaires administered to Filipino physicians were used to compute Cronbach\u27s α of PoPTQ. A total of 134 questionnaires of the same population were analyzed for Phase 2 (cross-sectional), in which descriptive statistics and cross tab analysis were used to report the respondents\u27 perceptions. Both phases utilized online means of data gathering done via convenience sampling. Results: Phase 1 revealed a Cronbach\u27s α value of 0.528 for all items of PoPTQ. Phase 2 showed that physicians who have attended lectures discussing the roles of PTs or have experience with working with them have a higher referral rate than those with no prior exposure to PTs. Discussion: Filipino physicians believe that PTs can establish strong patient-therapist relationships, treat different patients, and acknowledge the roles of PTs in clinical and research settings. Data suggest that adequate foundational knowledge, positive perceptions, and high awareness of PTs\u27 roles and scope of practice are observed among Filipino physicians. However, there remains a need to increase collaboration opportunities between PTs and physicians in their academic years and programs that focus on the promotion of PT roles and scope of practice

PERENCANAAN KEBUTUHAN MATERIAL (PKM) PADA PRODUKSI KINCIR ANGIN KAPASITAS 100 WATT

Banda Ace

Stilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity

It is well known that natural products are a rich source of compounds for applications in medicine, pharmacy, and biology. However, the exact molecular mechanisms of natural agents in human health have not been clearly defined. Here, we demonstrate for the first time that the polyphenolic phytoalexin resveratrol promotes expression and activity of Argonaute2 (Ago2), a central RNA interference (RNAi) component, which thereby inhibits breast cancer stem-like cell characteristics by increasing the expression of a number of tumour-suppressive miRNAs, including miR-16, -141, -143, and -200c. Most importantly, resveratrol-induced Ago2 resulted in a long-term gene silencing response. We also found that pterostilbene, which is a natural dimethylated resveratrol analogue, is capable of mediating Ago2-dependent anti-cancer activity in a manner mechanistically similar to that of resveratrol. These findings suggest that the dietary intake of natural products contributes to the prevention and treatment of diseases by regulating the RNAi pathway