Factors related to adolescent drinking in Appalachia

Objectives: To examine the relationships among parental monitoring, perceptions of peer drinking, and adolescent alcohol consumption. Methods: Tenth- and 12thgrade students (N=648) in a rural, Appalachian county were surveyed. Results: A binomial logistic regression revealed a composite of those who had perceptions that many peers drank, low parental monitoring, and no biological male guardian in the home were 8.496 times more likely to have ever been drunk. Other characteristics resulted in lower odds. Conclusions: Parental monitoring and perceptions of peer drinking were important predictors of drinking in this rural sample. Prevention efforts in school and at home should address both variables

Transfer of spectral weight across the gap of Sr2IrO4 induced by La doping

We study with Angle Resolved PhotoElectron Spectroscopy (ARPES) the evolution of the electronic structure of Sr2IrO4, when holes or electrons are introduced, through Rh or La substitutions. At low dopings, the added carriers occupy the first available states, at bottom or top of the gap, revealing an anisotropic gap of 0.7eV in good agreement with STM measurements. At further doping, we observe a reduction of the gap and a transfer of spectral weight across the gap, although the quasiparticle weight remains very small. We discuss the origin of the in-gap spectral weight as a local distribution of gap values

Free-Range Pre-Programmed RC Car

There is a growing interest in the capabilities and utilization of autonomous vehicles. The objective of this project is to design a small scale illustration of an autonomous vehicle driven by user input. An application will be designed that will allow a user to create a track that an RC car will accurately follow. As the car follows the track, a microcontroller on the vehicle will send movement information back to the application. This information is used by the application to process where the vehicle is currently at and where it needs to go. While in motion, on-board sensors will actively detect obstacles in the path and adjust the vehicle’s direction to avoid collision

The effect of stress fracture occurring within the first 12 months of training on subsequent race performance in Thoroughbreds in Hong Kong

BACKGROUND Racehorses are at an increased risk of stress fracture within the first 12 months of racing and when resuming training after a break. Research in these high-risk periods and on the effect of performance post-recovery is limited. OBJECTIVES To describe the occurrence of stress fractures, diagnosed by nuclear scintigraphy (NS), in racehorses' first 12 months training in Hong Kong, and their impact on racing performance and career length. STUDY DESIGN Retrospective 1:2 matched case-control study. METHODS Clinical records of horses with NS-diagnosed stress fractures within 365 days of import between 2006 and 2018 were collated. Cases and controls were matched on import date. Univariable conditional logistic regression compared signalment, pre-fracture training and post-recovery racing performance between cases and matched controls. Shared Frailty Cox regression analysed time from import to fracture and total career length. RESULTS Eighty-seven horses sustained a NS-diagnosed fracture within their first year in Hong Kong (incidence risk 1.7% (95% confidence interval (CI) 1.4-2.1%; N=5,180)). The humerus (42.0%; 95% CI 31.8-52.6%; n=39) and tibia (28.0%; 95% CI 19.1-38.2%; n=26) were most common stress fracture sites. Cases missed a median of 63 days (Interquartile range (IQR) 49-82) of training because of fracture. Within the 12 months following diagnosis, case horses had a median of four (IQR 2-4, p<0.0001) fewer race starts and were down HK$206,188 (IQR HK$0-436,800, p=0.007) in race earnings compared to controls. Career length did not significantly differ between cases and controls (median 2 years and 3 months; IQR 15.3-39.1 months; p=0.2). MAIN LIMITATIONS Only stress fractures diagnosed by NS were included, hence, the study is not representative of all stress fractures occurring in racehorses in Hong Kong. CONCLUSIONS Racehorses sustaining a stress fracture within one year of entering Hong Kong lost significant time in training, earnings and race starts. However, overall career length was unaffected

Short small-polaron lifetime in the mixed-valence perovskite Cs2_2Au2_2I6_6 from high-pressure pump-probe experiments

We study the ultrafast phonon response of mixed-valence perovskite Cs$_2$Au$_2$I$_6$ using pump-probe spectroscopy under high-pressure in a diamond anvil cell. We observed a remarkable softening and broadening of the Au - I stretching phonon mode with both applied pressure and photoexcitation. Using a double-pump scheme we measured a lifetime of the charge transfer excitation into single valence Au$^{2+}$ of less than 4 ps, which is an indication of the local character of the Au$^{2+}$ excitation. Furthermore, the strong similarity between the pressure and fluence dependence of the phonon softening shows that the inter-valence charge transfer plays an important role in the structural transition.Comment: 4 pages, 4 figure

Intraoperative electrocochleographic characteristics of auditory neuropathy spectrum disorder in cochlear implant subjects

Auditory neuropathy spectrum disorder (ANSD) is characterized by an apparent discrepancy between measures of cochlear and neural function based on auditory brainstem response (ABR) testing. Clinical indicators of ANSD are a present cochlear microphonic (CM) with small or absent wave V. Many identified ANSD patients have speech impairment severe enough that cochlear implantation (CI) is indicated. To better understand the cochleae identified with ANSD that lead to a CI, we performed intraoperative round window electrocochleography (ECochG) to tone bursts in children (n = 167) and adults (n = 163). Magnitudes of the responses to tones of different frequencies were summed to measure the “total response” (ECochG-TR), a metric often dominated by hair cell activity, and auditory nerve activity was estimated visually from the compound action potential (CAP) and auditory nerve neurophonic (ANN) as a ranked “Nerve Score”. Subjects identified as ANSD (45 ears in children, 3 in adults) had higher values of ECochG-TR than adult and pediatric subjects also receiving CIs not identified as ANSD. However, nerve scores of the ANSD group were similar to the other cohorts, although dominated by the ANN to low frequencies more than in the non-ANSD groups. To high frequencies, the common morphology of ANSD cases was a large CM and summating potential, and small or absent CAP. Common morphologies in other groups were either only a CM, or a combination of CM and CAP. These results indicate that responses to high frequencies, derived primarily from hair cells, are the main source of the CM used to evaluate ANSD in the clinical setting. However, the clinical tests do not capture the wide range of neural activity seen to low frequency sounds

Global long terminal repeat activation participates in establishing the unique gene expression programme of classical Hodgkin lymphoma

Long terminal repeat (LTR) elements are wide-spread in the human genome and have the potential to act as promoters and enhancers. Their expression is therefore under tight epigenetic control. We previously reported in classical Hodgkin Lymphoma (cHL) that a member of the THE1B class of LTR elements acted as a promoter for the proto-oncogene and growth factor receptor gene CSF1R and that expression of this gene is required for cHL tumour survival. However, to which extent and how such elements participate in globally shaping the unique cHL gene expression programme is unknown. To address this question we mapped the genome-wide activation of THE1-LTRs in cHL cells using a targeted next generation sequencing approach (RACE-Seq). Integration of these data with global gene expression data from cHL and control B cell lines showed a unique pattern of LTR activation impacting on gene expression, including genes associated with the cHL phenotype. We also show that global LTR activation is induced by strong inflammatory stimuli. Together these results demonstrate that LTR activation provides an additional layer of gene deregulation in classical Hodgkin lymphoma and highlight the potential impact of genome-wide LTR activation in other inflammatory diseases