Submarine Volcanism of the Cabo de Gata Magmatic Arc in the Betic-Rif Orogen, SE Spain: Processes and Products

Volcanic eruptions in subaqueous settings have been traditionally characterized by the study of ancient deposits and, more recently, by indirect observation of the sea floor with different geophysical means. Subaqueous volcanism is largely governed by the physical properties of water and the way water interacts with magma. Among the characteristic products of subaqueous volcanism are hyaloclastite breccias of dense clasts and of pumiceous clasts produced by the quench fragmentation of hot magma in effusive eruptions. Pumice breccias driven by fragmentation of magma in explosive eruptions are not infrequent. The Miocene volcanic zone of Cabo de Gata in southeastern Spain provides excellent exposures where to test the current understanding on subaqueous volcanism. In particular, submarine lavas with a coherent core and an outer carapace of vesicular hyaloclastite together with pumice breccias and crystal tuffs of the El Barronal Formation provide clues to understand transient conditions during explosive and effusive eruptions. Debris avalanches deposits are rather common in Cabo de Gata, such as those of the Los Frailes Formation and the Cerro Estorvillas Formation, and help to understand the instability processes of submarine volcanic edifices and the resultant mass flows. Interbedding of volcanic rocks with shallow water sedimentary rocks allows inferring water depth conditions for volcanism and the subsidence history of the volcano-sedimentary basin

Quickening the pulse: Fractal tempos in continental arc magmatism

The magmatic history of a continental arc can be characterized as punctuated equilibrium, whereby long periods of low-level activity are interrupted periodically by short bursts of high-volume magmatism (“flare-ups”). Geochronological records, most notably from zircon, reveal episodicity in volcanism, pluton formation, and detrital sedimentation in, and associated with, arc segments and volcano-plutonic suites. Distinct tempos can be recognized at all resolvable spatial and temporal scales and are broadly fractal, with each scale reflecting the timescale of processes occurring at different levels in the arc crust. The tempos of continental arc magmatism thus reflect modulation of the mantle-power input as it is progressively filtered through the continental crust

Facies architecture, emplacement mechanisms and eruption style of the submarine andesite El Barronal complex, Cabo de Gata, SE Spain

El Barronal complex consists of a succession of andesite lavas and andesite volcaniclastic facies interbedded with carbonate and siliciclastic sedimentary rocks. Carbonate and siliciclastic rocks were deposited in a shallow-marine environment during periods of volcanic quiescence. Lavas consist of an inner coherent core grading outward into hyaloclastite breccia made of dense clasts that in turn grade into hyaloclastite breccia made of vesicular clasts, in massive to layered zones. Volcaniclastic facies contain clasts produced during explosive eruptions and reworked clasts from sources above wave base. Volcaniclastic facies were deposited from cold granular flows with different grain size populations. Stratigraphy and facies architecture at El Barronal suggest that a succession of several discrete eruptive events occurred with a similar cyclic pattern made of an initial explosive phase followed by effusive emplacement of lavas, in turn followed by a period of quiescence of volcanic activity. Hyaloclastic fragmentation of magma took place in the final stages of lava emplacement, allowing only for local disorganization of the jigsaw-fit texture. © 2013 Elsevier B.V.This research has been funded by projects CGL2005-03511/BTE and HI2006-0073Peer Reviewe

Geochronology, geochemistry and geodynamics of the Cabo de Gata volcanic zone, Southeastern Spain

© 2014 Societa Geologica Italiana, Roma. New 40Ar/39Ar ages and major and trace element geochemistry of the middle-late Miocene Cabo de Gata volcanic complex, southeast Spain, indicate that the volcanic activity of the Cabo de Gata volcanic zone developed over a short period through several pulses of geochemically and isotopically different parental magmas. The oldest volcanic rocks exposed in the Cabo de Gata volcanic zone are the shoshonite and high-K calc-Alkaline rocks of Bujo group, which cry - stallised from a parental magma transitional from calc-Alkaline to alkaline potassic generated through large degrees of partial melting, and then affected by a minor contribution from metasomatised veins and a larger one from the surrounding mantle wedge, in comparison to ultrapotassic melts. Subsequent partial melting of the mantle source produced typical calc-Alkaline parental magmas belonging to the Rodalquilar and Agua Amarga groups. Sr-Nd-Pb isotope and incompatible trace element distributions of Cabo de Gata rocks are in agreement with a mantle-wedge source affected by a two-fold metasomatism. The data suggested that mild potassic to sub-Alkaline subduction-related parental magmas (i.e., high-K calc-Alkaline and calc-Alkaline) were generated in the Cabo de Gata sector within a mantle wedge metasomatised by a fluid-dominated agent. In contrast, the enrichment in K2O of shoshonitic to ultrapotassic magmas was achieved through recycling of subducted sediments through melts that enriched the mantle wedge in K and related elements. Such a scenario can be easily reconciled with a geodynamic setting at the edge of a destructive plate margin with the subducted slab responsible for the recycling of sediments within the mantle wedge.Geochemical, petrographic and analytical work were supported by the Italian MIUR through Cofin_2004 (grants #2004040502_001 and 2004040502_002), Cofin_2008 (grants #2008HMHYFP_002 and 2008HMHYFP_004) and Cofin_2010-2011 (grants #2010TT22SC_001, 2010TT22SC_005 and 2010TT22SC_006; 2010TT22SC_003) projects, to Sandro Conticelli and Massimo Mattei, respectively. Further financial support for geochronological analyses was provided by Spanish projects CGL2009-06968-E, CGL2005-03511/BTE and HI2006-0073 to Carles C. Soriano.Peer Reviewe

Geologic map, volcanic stratigraphy and structure of the Cabo de Gata volcanic zone, Betic-Rif orogen, SE Spain

The geologic map of the Neogene Cabo de Gata volcanic zone is presented together with a comprehensive volcanic stratigraphy and structure based on logging, correlation and mapping. Volcanic rocks are interbedded with sedimentary rocks throughout the Cabo de Gata volcanic zone. The volcano-sedimentary succession of Cabo de Gata has been divided into formations according to lithology, age, composition and stratigraphic position. The contacts between sedimentary units and volcanic units and between formations are unconformities. Sedimentary units were deposited during periods of volcanic repose. The depositional environment of volcanism in Cabo de Gata is characterized as shallow-water submarine to emergent based on lithofacies of volcanic rocks and on fossil content and sedimentary structures of sedimentary rocks. The eruptive style in Cabo de Gata is dominantly effusive, although small-volume explosive eruptions due to magma-water interaction processes and to explosions of lava flow and domes complexes occurred.Peer Reviewe

Bone Microenvironment Specific Roles of ITAM Adapter Signaling during Bone Remodeling Induced by Acute Estrogen-Deficiency

Immunoreceptor tyrosine-based activation motif (ITAM) signaling mediated by DAP12 or Fcε receptor Iγ chain (FcRγ) have been shown to be critical for osteoclast differentiation and maturation under normal physiological conditions. Their function in pathological conditions is unknown. We studied the role of ITAM signaling during rapid bone remodeling induced by acute estrogen-deficiency in wild-type (WT), DAP12-deficient (DAP12-/-), FcRγ-deficient (FcRγ-/-) and double-deficient (DAP12-/-FcRγ-/-) mice. Six weeks after ovariectomy (OVX), DAP12-/-FcRγ-/- mice showed resistance to lumbar vertebral body (LVB) trabecular bone loss, while WT, DAP12-/- and FcRγ-/- mice had significant LVB bone loss. In contrast, all ITAM adapter-deficient mice responded to OVX with bone loss in both femur and tibia of approximately 40%, relative to basal bone volumes. Only WT mice developed significant cortical bone loss after OVX. In vitro studies showed microenvironmental changes induced by OVX are indispensable for enhanced osteoclast formation and function. Cytokine changes, including TGFβ and TNFα, were able to induce osteoclastogenesis independent of RANKL in BMMs from WT but not DAP12-/- and DAP12-/-FcRγ-/- mice. FSH stimulated RANKL-induced osteoclast differentiation from BMMs in WT, but not DAP12-/- and DAP12-/-FcRγ-/- mice. Our study demonstrates that although ITAM adapter signaling is critical for normal bone remodeling, estrogen-deficiency induces an ITAM adapter-independent bypass mechanism allowing for enhanced osteoclastogenesis and activation in specific bony microenvironments

Maternal exposure to polychlorinated biphenyls and the secondary sex ratio: an occupational cohort study

Though commercial production of polychlorinated biphenyls was banned in the United States in 1977, exposure continues due to their environmental persistence. Several studies have examined the association between environmental polychlorinated biphenyl exposure and modulations of the secondary sex ratio, with conflicting results. Our objective was to evaluate the association between maternal preconceptional occupational polychlorinated biphenyl exposure and the secondary sex ratio. We examined primipara singleton births of 2595 women, who worked in three capacitor plants at least one year during the period polychlorinated biphenyls were used. Cumulative estimated maternal occupational polychlorinated biphenyl exposure at the time of the infant's conception was calculated from plant-specific job-exposure matrices. A logistic regression analysis was used to evaluate the association between maternal polychlorinated biphenyl exposure and male sex at birth (yes/no). Maternal body mass index at age 20, smoking status, and race did not vary between those occupationally exposed and those unexposed before the child's conception. Polychlorinated biphenyl-exposed mothers were, however, more likely to have used oral contraceptives and to have been older at the birth of their first child than non-occupationally exposed women. Among 1506 infants liveborn to polychlorinated biphenyl-exposed primiparous women, 49.8% were male; compared to 49.9% among those not exposed (n = 1089). Multivariate analyses controlling for mother's age and year of birth found no significant association between the odds of a male birth and mother's cumulative estimated polychlorinated biphenyl exposure to time of conception. Based on these data, we find no evidence of altered sex ratio among children born to primiparous polychlorinated biphenyl-exposed female workers

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Multisystem Inflammatory Syndrome in Children — Initial Therapy and Outcomes

This article is made available for unrestricted research re-use and secondary analysis in any form or be any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.Background: The assessment of real-world effectiveness of immunomodulatory medications for multisystem inflammatory syndrome in children (MIS-C) may guide therapy. Methods: We analyzed surveillance data on inpatients younger than 21 years of age who had MIS-C and were admitted to 1 of 58 U.S. hospitals between March 15 and October 31, 2020. The effectiveness of initial immunomodulatory therapy (day 0, indicating the first day any such therapy for MIS-C was given) with intravenous immune globulin (IVIG) plus glucocorticoids, as compared with IVIG alone, was evaluated with propensity-score matching and inverse probability weighting, with adjustment for baseline MIS-C severity and demographic characteristics. The primary outcome was cardiovascular dysfunction (a composite of left ventricular dysfunction or shock resulting in the use of vasopressors) on or after day 2. Secondary outcomes included the components of the primary outcome, the receipt of adjunctive treatment (glucocorticoids in patients not already receiving glucocorticoids on day 0, a biologic, or a second dose of IVIG) on or after day 1, and persistent or recurrent fever on or after day 2. Results: A total of 518 patients with MIS-C (median age, 8.7 years) received at least one immunomodulatory therapy; 75% had been previously healthy, and 9 died. In the propensity-score-matched analysis, initial treatment with IVIG plus glucocorticoids (103 patients) was associated with a lower risk of cardiovascular dysfunction on or after day 2 than IVIG alone (103 patients) (17% vs. 31%; risk ratio, 0.56; 95% confidence interval [CI], 0.34 to 0.94). The risks of the components of the composite outcome were also lower among those who received IVIG plus glucocorticoids: left ventricular dysfunction occurred in 8% and 17% of the patients, respectively (risk ratio, 0.46; 95% CI, 0.19 to 1.15), and shock resulting in vasopressor use in 13% and 24% (risk ratio, 0.54; 95% CI, 0.29 to 1.00). The use of adjunctive therapy was lower among patients who received IVIG plus glucocorticoids than among those who received IVIG alone (34% vs. 70%; risk ratio, 0.49; 95% CI, 0.36 to 0.65), but the risk of fever was unaffected (31% and 40%, respectively; risk ratio, 0.78; 95% CI, 0.53 to 1.13). The inverse-probability-weighted analysis confirmed the results of the propensity-score-matched analysis. Conclusions: Among children and adolescents with MIS-C, initial treatment with IVIG plus glucocorticoids was associated with a lower risk of new or persistent cardiovascular dysfunction than IVIG alone. (Funded by the Centers for Disease Control and Prevention.)

Cyclic growth and mass wasting of submarine Los Frailes lava flow and dome complex in Cabo de Gata, SE Spain

The Los Frailes Formation lava-flow and dome complex is a Miocene succession that is part of the Cabo de Gata volcanic zone of SE Spain. The complex comprises dominantly dacitic, subaqueous dome rocks and interstratified sedimentary horizons emplaced over a few tens of thousands of years. Facies of the Los Frailes Formation include coherent lava, in-situ hyaloclastite, locally with microfossil-bearing siltstone matrix, pumiceous and block-rich tuff, and massive monomict breccia and megabreccia, in which clasts are locally several metres in diameter. The monomict megabreccias display both >block facies> and >matrix facies> architecture and show internal deformation at the block-matrix contacts. They are inferred to have derived from debris avalanches. Facies are divided into four volcanic units separated by fossiliferous marine sedimentary units emplaced during hiatuses in volcanism. The Los Frailes Formation lava-flow and dome complex were emplaced in a shallow setting that may have included emergent areas. Lava flows and the margins of dome edifices interacted with sea water to form hyaloclastite, and pyroclastic currents deposited pumiceous materials. Sector collapse of marine domes fed small-volume debris avalanches with generally the same facies and distribution of facies as the larger-scale equivalents on which traditional models are built. © 2012 Elsevier B.V.This research was funded by projects CGL2005-03511/BTE, HI2006-0073 and CGL2009-06968-E from the Ministerio de Ciencia e Innovación of Spain. Chemical analyseswere performedwith the financial support of ItalianMIUR — PRIN 2008 funds, and grant 2008HMHYFP_002 issued to Conticelli.Peer Reviewe