Raymonden, abri

Le siteSous le nom de Raymonden sont en réalité regroupés deux locus diversement célèbres. Le premier site (Raymonden nord) a fait l’objet de fouilles pionnières dès 1874. Son couloir – exploité plus tardivement par L. Mercier – a, dans les années 1930, livré une séquence allant du Moustérien à l’Aurignacien avec deux niveaux de Châtelperronien. La présence du Magdalénien y a également été relevée.La séquence magdalénienne est en revanche particulièrement bien présente dans le second locus, ..

Design of a duplicated fault-detecting AES chip and yet using clock set-up time violations to extract 13 out of 16 bytes of the secret key

International audienceThe secret keys manipulated by cryptographic circuits can be extracted using fault injections associated with differential cryptanalysis techniques [1]. Such faults can be induced by different means such as lasers, voltage glitches, electromagnetic perturbations or clock skews. Several counter-measures have been proposed such as random delay insertions, circuit duplications or error correcting codes. In this paper, we focus on an AES chip in which the circuit duplication principle has been implemented to detect fault injection. We show that faults based on clock set-up time violations can nevertheless be used to defeat the implemented counter-measure

Neurourology and Urodynamics Diagnostic Criteria for Pudendal Neuralgia by Pudendal Nerve Entrapment (Nantes Criteria)

Aims: The diagnosis of pudendal neuralgia by pudendal nerve entrapment syndrome is essentially clinical. There are no pathognomonic criteria, but various clinical features can be suggestive of the diagnosis. We defined criteria that can help to the diagnosis. Materials and Methods: A working party has validated a set of simple diagnostic criteria (Nantes criteria). Results: The five essentials diagnostic criteria are: (1) Pain in the anatomical territory of the pudendal nerve

Sirènement de boîte de vitesses automobile : confrontation calcul/essais en contexte réel

Le sirènement de boîte de vitesses est un bruit associé aux vibrations carter. La source excitatrice de nature paramétrique (raideur périodique) résulte du contact étroit entre dentures et de leurs micro-géométries. Pour des cas réels, la prédiction reste un problème difficile. Des méthodes numériques permettent de le traiter des échelles micro (denture) aux échelles macro (carter). Un modèle complet de 1,2 millions de ddl est mis en uvre. Les résultats numériques sont confrontés à ceux d essais expérimentaux (100 voies de mesures). De nombreux régimes de fonctionnement ont été réalisés

Relationships between Personality Traits, Medial Temporal Lobe Atrophy, and White Matter Lesion in Subjects Suffering from Mild Cognitive Impairment

Mild cognitive impairment (MCI) is a heterogeneous cognitive status that can be a prodromal stage of Alzheimer’s disease (AD). It is particularly relevant to focus on prodromal stages of AD such as MCI, because patho-physiological abnormalities of AD start years before the dementia stage. Medial temporal lobe (MTL) atrophy resulting from AD lesions and cerebrovascular lesions [i.e., white matter lesions (WML), lacunar strokes, and strokes] are often revealed concurrently on magnetic resonance imaging (MRI) in MCI subjects. Personality changes have been reported to be associated with MCI status and early AD. More specifically, an increase in neuroticism and a decrease in conscientiousness have been reported, suggesting that higher and lower scores, respectively, in neuroticism and conscientiousness are associated with an increased risk of developing the disease. However, personality changes have not been studied concomitantly with pathological structural brain alterations detected on MRI in patients suffering from MCI. Therefore, the objective of the present study was to assess the relationship between MTL atrophy, WML, lacunar strokes, and personality traits in such patients. The severity of WML was strongly associated with lower levels of conscientiousness and higher levels of neuroticism. Conversely, no association was detected between personality traits and the presence of lacunar strokes or MTL atrophy. Altogether, these results strongly suggest that personality changes occurring in a MCI population, at high risk of AD, are associated with WML, which can induce executive dysfunctions, rather than with MTL atrophy

Somatostatin and Neuropeptide Y in Cerebrospinal Fluid: Correlations With Amyloid Peptides Aβ1–42 and Tau Proteins in Elderly Patients With Mild Cognitive Impairment

A combination of low cerebrospinal fluid (CSF) Amyloid β1–42 (Aβ1–42) and high Total-Tau (T-Tau) and Phosphorylated-Tau (P-Tau) occurs at a prodromal stage of Alzheimer’s disease (AD) and recent findings suggest that network abnormalities and interneurons dysfunction contribute to cognitive deficits. Somatostatin (SOM) and Neuropeptide Y (NPY) are two neuropeptides which are expressed in GABAergic interneurons with different fates in AD the former only being markedly affected. The aim of this study was to analyze CSF SOM, NPY and CSF Aβ1–42; T-Tau, P-Tau relationships in 43 elderly mild cognitively impairment (MCI) participants from the Biomarker of AmyLoïd pepTide and AlZheimer’s disease Risk (BALTAZAR) cohort. In these samples, CSF SOM and CSF Aβ1–42 on the one hand, and CSF NPY and CSF T-Tau and P-Tau on the other hand are positively correlated. CSF SOM and NPY concentrations should be further investigated to determine if they can stand for early AD biomarkers.Clinical Trial Registration: www.ClinicalTrials.gov, identifier #NCT01315639

Estudio de las necesidades recreacionales de los habitantes del cantón Milagro y su relación con el turismo en el año 2015.

La palabra recreación define a la acción y efecto de recrear. Por lo tanto, puede hacer referencia a crear o producir de nuevo algo. También se refiere a divertir, alegrar o deleitar, en una búsqueda de distracción en medio del trabajo y de las obligaciones cotidianas. El presente proyecto tiene como finalidad llegar a los centros turísticos de recreación para que puedan ofrecer a niños y adultos una opción de descanso, entretenimiento y diversión a través de las diferentes actividades turísticas que puedan ofrecer a los mismos. El descanso se le otorgo, tanto el sentido de compensación a la fatiga producto del trabajo, como el de la respuesta natural a las necesidades filosóficas del organismo que imponen a la necesidad de dormir. Se descansaba para poder recuperar y para compensar el agotamiento que produce el trabajo intelectual o las tensiones emocionales. El ser humano necesita tiempo de ocio o tiempo libre ya que es importante que se encuentre en óptimas condiciones físicas, emocionalmente y mentalmente para que realicen un mejor desempeño en los estudios como en lo laboral. En esta investigación se busca que los centros recreacionales dispongan de variedades actividades turísticas para que así, la demanda turística realice gasto por turismo interno el mismo que favorecerá a nuestra ciudad

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe