547 research outputs found
Peritumoral administration of GPI-anchored TIMP-1 inhibits colon carcinoma growth in Rag-2 gamma chain-deficient mice
Exogenous application of recombinant TIMP-1 protein modified by addition of a glycosylphosphatidylinositol (GPI) anchor allows efficient insertion of the fusion protein into cell membranes. This `cell surface engineering' leads to changes in the proteolytic environment. TIMP-1-GPI shows enhanced as well as novel in vitro biological activities including suppression of proliferation, reduced migration, and inhibition of invasion of the colon carcinoma cell line SW480. Treatment of SW480 tumors implanted in Rag (-/-) common gamma chain (-/-) C57BL/6 mice with peritumorally applied TIMP-1-GPI, control rhTIMP-1 protein, or vehicle shows that TIMP-1-GPI leads to a significant reduction in tumor growth
Stability of an Exciton bound to an Ionized Donor in Quantum Dots
Total energy, binding energy, recombination rate (of the electron hole pair)
for an exciton (X) bound in a parabolic two dimensional quantum dot by a donor
impurity located on the z axis at a distance d from the dot plane, are
calculated by using the Hartree formalism with a recently developed numerical
method (PMM) for the solution of the Schroedinger equation. As our analysis
indicates there is a critical dot radius such that for radius less than the
critical radius the complex is unstable and with an increase of the impurity
distance this critical radius increases. Furthermore, there is a critical value
of the mass ratio such that for mass ratio less than the critical value the
complex is stable. The appearance of this stability condition depends both on
the impurity distance and the dot radius, in a way that with an increase of the
impurity distance we have an increase in the maximum dot radius where this
stability condition appears. For dot radii greater than this maximum dot radius
(for fixed impurity distance) the complex is always stable.Comment: 17 pages, 7 figures Applying a new numerical method which is based on
the adiabatic stability of quantum mechanics, we study the stability of an
exciton (X) bound in a parabolic two dimensional quantum dot by a donor
impurity located on the z axis at a distance d from the dot plan
Post-Newtonian Freely Specifiable Initial Data for Binary Black Holes in Numerical Relativity
Construction of astrophysically realistic initial data remains a central
problem when modelling the merger and eventual coalescence of binary black
holes in numerical relativity. The objective of this paper is to provide
astrophysically realistic freely specifiable initial data for binary black hole
systems in numerical relativity, which are in agreement with post-Newtonian
results. Following the approach taken by Blanchet, we propose a particular
solution to the time-asymmetric constraint equations, which represent a system
of two moving black holes, in the form of the standard conformal decomposition
of the spatial metric and the extrinsic curvature. The solution for the spatial
metric is given in symmetric tracefree form, as well as in Dirac coordinates.
We show that the solution differs from the usual post-Newtonian metric up to
the 2PN order by a coordinate transformation. In addition, the solutions,
defined at every point of space, differ at second post-Newtonian order from the
exact, conformally flat, Bowen-York solution of the constraints.Comment: 41 pages, no figures, accepted for publication in Phys. Rev. D,
significant revision in presentation (including added references and
corrected typos
The Loschmidt Echo as a robust decoherence quantifier for many-body systems
We employ the Loschmidt Echo, i.e. the signal recovered after the reversal of
an evolution, to identify and quantify the processes contributing to
decoherence. This procedure, which has been extensively used in single particle
physics, is here employed in a spin ladder. The isolated chains have 1/2 spins
with XY interaction and their excitations would sustain a one-body like
propagation. One of them constitutes the controlled system S whose reversible
dynamics is degraded by the weak coupling with the uncontrolled second chain,
i.e. the environment E. The perturbative SE coupling is swept through arbitrary
combinations of XY and Ising like interactions, that contain the standard
Heisenberg and dipolar ones. Different time regimes are identified for the
Loschmidt Echo dynamics in this perturbative configuration. In particular, the
exponential decay scales as a Fermi golden rule, where the contributions of the
different SE terms are individually evaluated and analyzed. Comparisons with
previous analytical and numerical evaluations of decoherence based on the
attenuation of specific interferences, show that the Loschmidt Echo is an
advantageous decoherence quantifier at any time, regardless of the S internal
dynamics.Comment: 12 pages, 6 figure
New insights into microstructure of neutron-irradiated tungsten
The development of appropriate materials for fusion reactors that can sustain high neutron fluence at elevated temperatures remains a great challenge. Tungsten is one of the promising candidate materials for plasma-facing components of future fusion reactors, due to several favorable properties as for example a high melting point, a high sputtering resistivity, and a low coefficient of thermal expansion. The microstructural details of a tungsten sample with a 1.25 dpa (displacements per atom) damage dose after neutron irradiation at 800 °C were examined by transmission electron microscopy. Three types of radiation-induced defects were observed, analyzed and characterized: (1) voids with sizes ranging from 10 to 65 nm, (2) dislocation loops with a size of up to 10 nm and (3) W–Re–Os containing σ- and χ-type precipitates. The distribution of voids as well as the nature of the occurring dislocation loops were studied in detail. In addition, nano-chemical analyses revealed that the σ- and χ-type precipitates, which are sometimes attached to voids, are surrounded by a solid solution cloud enriched with Re. For the first time the crystallographic orientation relationship of the σ- and χ-phases to the W-matrix was specified. Furthermore, electron energy-loss spectroscopy could not unambiguously verify the presence of He within individual voids
Host-induced gene silencing in the necrotrophic fungal pathogen Sclerotinia sclerotiorum.
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Energy spectra, wavefunctions and quantum diffusion for quasiperiodic systems
We study energy spectra, eigenstates and quantum diffusion for one- and
two-dimensional quasiperiodic tight-binding models. As our one-dimensional
model system we choose the silver mean or `octonacci' chain. The
two-dimensional labyrinth tiling, which is related to the octagonal tiling, is
derived from a product of two octonacci chains. This makes it possible to treat
rather large systems numerically. For the octonacci chain, one finds singular
continuous energy spectra and critical eigenstates which is the typical
behaviour for one-dimensional Schr"odinger operators based on substitution
sequences. The energy spectra for the labyrinth tiling can, depending on the
strength of the quasiperiodic modulation, be either band-like or fractal-like.
However, the eigenstates are multifractal. The temporal spreading of a
wavepacket is described in terms of the autocorrelation function C(t) and the
mean square displacement d(t). In all cases, we observe power laws for C(t) and
d(t) with exponents -delta and beta, respectively. For the octonacci chain,
0<delta<1, whereas for the labyrinth tiling a crossover is observed from
delta=1 to 0<delta<1 with increasing modulation strength. Corresponding to the
multifractal eigenstates, we obtain anomalous diffusion with 0<beta<1 for both
systems. Moreover, we find that the behaviour of C(t) and d(t) is independent
of the shape and the location of the initial wavepacket. We use our results to
check several relations between the diffusion exponent beta and the fractal
dimensions of energy spectra and eigenstates that were proposed in the
literature.Comment: 24 pages, REVTeX, 10 PostScript figures included, major revision, new
results adde
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