2,842 research outputs found

    Extending Barrett’s esophagus cancer risk profile towards genetic abnormalities

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    Within-ring movement of free water in dehydrating Norway spruce sapwood visualized by neutron radiography

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    This study is a first approach to visualize moisture distribution and movement between annual rings during sapwood drying by neutron imaging (NI). While Norway spruce [Picea abies (L.) Karst.] sapwood beams were allowed to dehydrate on a balance at ambient conditions, NI was performed in 1-10 min time steps. From NI raw files, radial dimensional changes were calculated during dehydration and transmission profiles were drawn for different relative moisture content (MC) steps from full saturation until equilibrium moisture content. The NI technique proved to be a useful tool to visualize the movement of free water within, and between, annual rings. Removal of free water in the middle part of the wood beam did not proceed continuously from the surface to the central part, but was strongly influenced by wood anatomy. Water is removed from earlywood during early stages of dehydration and later, at higher moisture loss (<50% MC), from the main latewood parts. It is therefore concluded that the radial dimensional changes measured at moderate moisture loss are not only caused by cell wall shrinkage of the outer wood parts located beneath the wood surface, but a result of elastic deformation of earlywood tracheids under the influence of negative hydrostatic pressure

    High-resolution ultrasound visualization of the recurrent motor branch of the median nerve: normal and first pathological findings

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    Purpose To evaluate in a prospective study the possibility of visualization and diagnostic assessment of the recurrent motor branch (RMB) of the median nerve with high-resolution ultrasound (HRUS). Materials and methods HRUS with high-frequency probes (1822 MhZ) was used to locate the RMB in eight fresh cadaveric hands. To verify correct identification, ink-marking and consecutive dissection were performed. Measurement of the RMB maximum transverse-diameter, an evaluation of the origin from the median nerve and its course in relation to the transverse carpal ligament, was performed in both hands of ten healthy volunteers (n=20). Cases referred for HRUS examinations for suspected RMB lesions were also assessed. Results The RMB was clearly visible in all anatomical specimens and all volunteers. Dissection confirmed HRUS findings in all anatomical specimens. Mean RMB diameter in volunteers was 0.7 mm 0.1 (range, 0.61). The RMB originated from the radial aspect in 11 (55%), central aspect in eight (40%) and ulnar aspect in one (5%) hand. Nineteen (95%) extraligamentous courses and one (5%) subligamentous course were detected. Three patients with visible RMB abnormalities on HRUS were identified. Conclusion HRUS is able to reliably visualize the RMB, its variations and pathologies. Key Points Ultrasound allows visualization of the recurrent motor branch of the median nerve. Ultrasound may help clinicians to assess patients with recurrent motor branch pathologies. Patient management may become more appropriate and targeted therapy could be improved.(VLID)354468

    Resolution limits of drift tubes

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    Measurements of the drift-tube response to charged particle tracks are compared with a complete simulation. The measured resolution of typically 80\,μ\mum agrees well with the simulation and allows the individual factors limiting the resolution such as diffusion, charge deposit fluctuations, gas gain fluctuations and signal processing to be studied. The results with respect to the dependence of the drift chamber resolution on gas gain, gas pressure and electronics parameters are reported

    Front-end electronics for drift tubes in a high-rate environment

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    A front-end electronics readout for drift tubes in a high-rate environment is presented. This system allows us to encode several pieces of information (leading edge time, trailing edge time, signal charge and piled-up hits from multiple tracks) into a single readout channel that is presented to the TDC. The advantage of active baseline restoration compared to bipolar signal shaping is discussed

    Rate effects in high-resolution drift chambers

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    The impact of high counting rates on the spatial resolution of cylindrical drift tubes is investigated in detail and the results are compared with simulations. Electronics effects and space-charge effects are quantitatively analysed. A spatial resolution of σ<80 μm\sigma < 80\,\mu\mathrm{m} can be achieved even at rates as high as 1500\,Hz/cm wire length (300\,kHz per wire)

    Chronic hyperglycemia is associated with acute kidney injury in patients undergoing CABG surgery – a cohort study

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    Background Chronic hyperglycemia (CHG) with HbA1c as an indicator affects postoperative mortality and morbidity after coronary artery bypass grafting surgery (CABG). Acute kidney injury (AKI) is one of the frequent postoperative complications after CABG impacting short-and long-term outcomes. We investigated the association between CHG and postoperative incidence of AKI in CABG patients with and without history of diabetes mellitus (DM). Methods This cohort study consecutively enrolled patients undergoing CABG in 2009 at the department for cardiovascular surgery. CHG was defined as HbA1c ≥ 6.0 %. Patients with advanced chronic kidney disease (CKD) were excluded. The incidence of postoperative AKI and its association with CHG was analyzed by univariate and multivariate logistic regression modeling. Results Three-hundred-seven patients were analyzed. The incidence of AKI was 48.2 %. Patients with CHG (n = 165) were more likely to be female and had greater waist circumference as well as other comorbid conditions, such as smoking, history of DM, CKD, hypertension, pulmonary hypertension, and chronic obstructive pulmonary disease (all p ≤ 0.05). Preoperative eGFR, atrial fibrillation (AF), history of DM and CHG were associated with an increased risk of postoperative AKI in univariate analyses. In multivariate modelling, history of DM as well as preoperative eGFR and AF lost significance, while age, CHG and prolonged OP duration (p < 0.05) were independently associated with postoperative AKI. Conclusions Our results suggest that CHG defined on a single measurement of HbA1c ≥ 6.0 % was associated with the incidence of AKI after CABG. This finding might implicate that treatment decisions, including the selection of operative strategies, could be based on HbA1c measurement rather than on a recorded history of diabetes

    Dependence of Drift Tube Performance on the Anode Wire Diameter

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    Cylindrical pressurized drift tubes with different anode wire diameters wereoperated in a 170~GeV muon test beam. The dependences of spatialresolution, efficiency and streamer probability on the anode wirediameter were measured. The resolution measurements are compared with a simulation
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