The concreteness of concrete art

An analysis of the use of the term 'concrete' in twentieth-century art.PostprintPeer reviewe

The routine art

This essay examines a trend within contemporary art, in which artists make their lifestyle or a specific ongoing activity as significant as any completed work of art that they might produce.PostprintPeer reviewe

The skin is a screen

This essay discusses works produced over the first ten years of the career of the Syrian American artist Diana Al-Hadid, and is to be published in an exhibition catalogue entitled "Diana Al-Hadid: Phantom Limb", in conjunction with a retrospective of her work at NYUAD Art Gallery, Abu Dhabi, and David Winton Bell Gallery, Brown University, Rhode Island.Postprin

Dimensions of participation. Experiences, lessons and tips from agricultural research practitioners in Sub-Saharan Africa

This book is about participation in agricultural research. It documents the experience of practitioners in implementing agricultural research projects in which participation has been a central issue. This experience is documented through case studies, and through summaries of the authors' experience. Reference is made to other literature on aspects of participation, both specific and general. The case studies give first hand accounts of the challenges and successes involved in using participatory approaches in agricultural research projects undertaking technology development and adaptation. Written by practitioners, the case studies cover many practical aspects of design and implementation that are not covered in more academic and conceptual writing on this subject, or in general manuals on how to undertake participatory agricultural research. The existing books, manuals and guidelines adequately outline the key principles and approaches in participatory agricultural research (e.g. Okali et al., 1994; Van Veldhuizen et al., 1997; Sutherland, 1998). This book is different from most others on participatory agricultural research in the following respects: it organizes and compares case-study experiences within topical chapters, rather than having case studies written as separate chapters; it embraces a wider view of participation- in addition to interaction between farmers and researchers, this view includes participation both within project teams and between the project team and other stakeholders in the agricultural research process; it is not a training manual detailing what to do, when to do it and how; however, lessons and tips are provided for the topics covered; it is rooted in project experiences rather than in development discourse, and does not advocate a particular participatory research philosophy, or claim to break new ground in terms of participatory concepts and methods. The aim of the book is to stimulate learning, primarily by presenting examples of how a range of projects handled various components of the participatory research process. These examples are given within a broader discussion of the typical challenges and issues faced by projects and practitioners when using participatory approaches to develop and adapt agricultural technology. Drawing on the case studies and other experiences, some lessons, strategies and tips are outlined in relation to particular topics within participatory agricultural research

Heritability of haemodynamics in the ascending aorta

From Springer Nature via Jisc Publications RouterHistory: received 2020-03-23, accepted 2020-06-25, registration 2020-08-17, pub-electronic 2020-09-01, online 2020-09-01, collection 2020-12Publication status: PublishedFunder: Medical Research Council; doi: http://dx.doi.org/10.13039/501100000265; Grant(s): MR/K501311/1Funder: Engineering and Physical Sciences Research Council; doi: http://dx.doi.org/10.13039/501100000266; Grant(s): EP/N509565/1Funder: British Heart Foundation; doi: http://dx.doi.org/10.13039/501100000274; Grant(s): Personal ChairAbstract: Blood flow in the vasculature can be characterised by dimensionless numbers commonly used to define the level of instabilities in the flow, for example the Reynolds number, Re. Haemodynamics play a key role in cardiovascular disease (CVD) progression. Genetic studies have identified mechanosensitive genes with causal roles in CVD. Given that CVD is highly heritable and abnormal blood flow may increase risk, we investigated the heritability of fluid metrics in the ascending aorta calculated using patient-specific data from cardiac magnetic resonance (CMR) imaging. 341 participants from 108 British Caucasian families were phenotyped by CMR and genotyped for 557,124 SNPs. Flow metrics were derived from the CMR images to provide some local information about blood flow in the ascending aorta, based on maximum values at systole at a single location, denoted max, and a ‘peak mean’ value averaged over the area of the cross section, denoted pm. Heritability was estimated using pedigree-based (QTDT) and SNP-based (GCTA-GREML) methods. Estimates of Reynolds number based on spatially averaged local flow during systole showed substantial heritability (hPed2=41%[P=0.001], hSNP2=39%[P=0.002]), while the estimated heritability for Reynolds number calculated using the absolute local maximum velocity was not statistically significant (12–13%; P>0.05). Heritability estimates of the geometric quantities alone; e.g. aortic diameter (hPed2=29%[P=0.009], hSNP2=30%[P=0.010]), were also substantially heritable, as described previously. These findings indicate the potential for the discovery of genetic factors influencing haemodynamic traits in large-scale genotyped and phenotyped cohorts where local spatial averaging is used, rather than instantaneous values. Future Mendelian randomisation studies of aortic haemodynamic estimates, which are swift to derive in a clinical setting, will allow for the investigation of causality of abnormal blood flow in CVD

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Carl Andre Sculptures, Politics, 1959-1976

This work is premised on the assumption that the excuses for not engaging properly with Carl Andre's corpus will not stand forever, and that his art is capable of sustaining considerably more attention than it has been afforded to date. Focusing predominantly on a select number of works from 1959 (when Andre moved to New York City) to 1976 (the year of the media orchestrated uproar over the Tate Gallery's purchase of Equivalent VIII) this dissertation assessesth e singular nature of his brand of late modernism. Much to the chagrin of many, few US artists of the 1960s aligned themselves so intimately with a Marxist cause or thought so carefully about art's commodity status. This project takes these facts seriously and attempts to approach the art accordingly. The works discussed include America Drill (1963), the Equivalents (1966), Lever (1966), Gold Field (1966), 5x 20 Altstadt Rectangle (1967), Joint (1968), Quincy Book (1973), Twelfth Copper Corner (1975) and Manet (1980)

On Kawara: New York

Review of the career retrospective exhibition of 'On Kawara: Silence' at the Solomon R. Guggenheim Museum, New Yor

Manfred Mohr:Scripted Variations

A discussion of the art of the internationally respected computer artist, Manfred Moh