3 research outputs found

    Colostrum Features of Active and Recovered COVID-19 Patients Revealed Using Next-Generation Proteomics Technique, SWATH-MS

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    Colostrum performs nutritional, anti-inflammatory and anti-infective functions and promotes immune system formation and organ development. The new coronavirus, SARS-CoV-2, has generated concerns about viral transmission through human milk, with a lack of evidence about human milk’s protective effects against the infection. This study aimed at analyzing presence of the virus and at identifying the protein expression profile of human colostrum in active and COVID-19-recovered patients. Colostrum samples were collected from women with COVID-19 (n = 3), women recently recovered from the infection (n = 4), and non-infected women (n = 5). The samples were analyzed by means of RT-qPCR to determine presence of the virus and using SWATH-MS for proteomic analysis. Proteomic results were then analyzed using bioinformatic methods. The viral tests were negative for SARS-CoV-2 in the colostrum from COVID-19 patients. The proteomic analysis identified 301 common proteins in all samples analyzed. Nineteen proteins were upregulated and 7 were downregulated in the COVID-19 group versus the control samples, whereas 18 were upregulated and 7 were downregulated when comparing the COVID-19 group to the recovered group. Eleven proteins were biomarkers of active COVID-19 infection. Ten were upregulated: ACTN1, CD36, FAM3B, GPRC5B, IGHA2, IGK, PLTP, RAC1, SDCBP and SERPINF1, and one was downregulated: PSAP. These proteins are mainly related to immunity, inflammatory response and protein transport. In conclusion, the results of this study suggest that colostrum is not a vehicle for mother-to-child SARS-CoV-2 transmission. Moreover, the colostrum’s proteome of active and recuperated patients indicate that it could provide immune benefits to infants

    Creative ART Interchange Barcelona-Chicago. Projecte d’intercanvi artístic entre escoles de Barcelona i Chicago

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    La idea de fer aquest projecte va començar l'any 2009/10 quan el Govern de Catalunya va donar una beca a Glòria Martí Rubí per fer una recerca d'educació artística a la ciutat de Chicago (IL), Grand Rapits (MI) i Barcelona(CAT). Durant la recerca hi van haver molts contactes amb artistes, artterapeutes i professors d'art com Rene Arceo que junt amb Glòria Martí són els coordinadors d’aquest nou projecte. L’objectiu és posar en contacte a professors/es i alumnes de l'àrea artística d’ Escoles i Instituts de Chicago i de Barcelona -sense descartar ampliar-ho a tot Catalunya- per intercanviar idees, treballs i experiències. L'art permet conèixer i aprofundir en les realitats culturals de cada país. El tema general a treballar per totes les escoles és “La Meva Ciutat”
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