Point perturbations of circle billiards

The spectral statistics of the circular billiard with a point-scatterer is investigated. In the semiclassical limit, the spectrum is demonstrated to be composed of two uncorrelated level sequences. The first corresponds to states for which the scatterer is located in the classically forbidden region and its energy levels are not affected by the scatterer in the semiclassical limit while the second sequence contains the levels which are affected by the point-scatterer. The nearest neighbor spacing distribution which results from the superposition of these sequences is calculated analytically within some approximation and good agreement with the distribution that was computed numerically is found.Comment: 9 pages, 2 figure

An invitation to grieve: reconsidering critical incident responses by support teams in the school setting

This paper proposes that consideration could be given to an invitational intervention rather than an expectational intervention when support personnel respond to a critical incident in schools. Intuitively many practitioners know that it is necessary for guidance/counselling personnel to intervene in schools in and following times of trauma. Most educational authorities in Australia have mandated the formulation of a critical incident intervention plan. This paper defines the term critical incident and then outlines current intervention processes, discussing the efficacy of debriefing interventions. Recent literature suggests that even though it is accepted that a planned intervention is necessary, there is scant evidence as to the effectiveness of debriefing interventions in stemming later symptoms of post traumatic stress disorder. The authors of this paper advocate for an expressive therapy intervention that is invitational rather than expectational, arguing that not all people respond to trauma in the same way and to expect that they will need to recall and retell what has happened is most likely a dangerous assumption. A model of invitation using Howard Gardner’s (1983) multiple intelligences is proposed so that students are invited to grieve and understand emotionally what is happening to them following a critical incident

Granular Rheology in Zero Gravity

We present an experimental investigation on the rheological behavior of model granular media made of nearly elastic spherical particles. The experiments are performed in a cylindrical Couette geometry and the experimental device is placed inside an airplane undergoing parabolic flights to cancel the effect of gravity. The corresponding curves, shear stress versus shear rate, are presented and a comparison with existing theories is proposed. The quadratic dependence on the shear rate is clearly shown and the behavior as a function of the solid volume fraction of particles exhibits a power law function. It is shown that theoretical predictions overestimate the experiments. We observe, at intermediate volume fractions, the formation of rings of particles regularly spaced along the height of the cell. The differences observed between experimental results and theoretical predictions are discussed and related to the structures formed in the granular medium submitted to the external shear.Comment: 10 pages, 6 figures to be published in Journal of Physics : Condensed Matte

Independent evaluation of a simple clinical prediction rule to identify right ventricular dysfunction in patients with shortness of breath

BACKGROUND: Many patients have unexplained persistent dyspnea after negative computed tomographic pulmonary angiography (CTPA). We hypothesized that many of these patients have isolated right ventricular (RV) dysfunction from treatable causes. We previously derived a clinical decision rule (CDR) for predicting RV dysfunction consisting of persistent dyspnea and normal CTPA, finding that 53% of CDR-positive patients had isolated RV dysfunction. Our goal is to validate this previously derived CDR by measuring the prevalence of RV dysfunction and outcomes in dyspneic emergency department patients. METHODS: A secondary analysis of a prospective observational multicenter study that enrolled patients presenting with suspected PE was performed. We included patients with persistent dyspnea, a nonsignificant CTPA, and formal echo performed. Right ventricular dysfunction was defined as RV hypokinesis and/or dilation with or without moderate to severe tricuspid regurgitation. RESULTS: A total of 7940 patients were enrolled. Two thousand six hundred sixteen patients were analyzed after excluding patients without persistent dyspnea and those with a significant finding on CTPA. One hundred ninety eight patients had echocardiography performed as standard care. Of those, 19% (95% confidence interval [CI], 14%-25%) and 33% (95% CI, 25%-42%) exhibited RV dysfunction and isolated RV dysfunction, respectively. Patients with isolated RV dysfunction or overload were more likely than those without RV dysfunction to have a return visit to the emergency department within 45 days for the same complaint (39% vs 18%; 95% CI of the difference, 4%-38%). CONCLUSION: This simple clinical prediction rule predicted a 33% prevalence of isolated RV dysfunction or overload. Patients with isolated RV dysfunction had higher recidivism rates and a trend toward worse outcomes

Heavy- to light-meson transition form factors

Semileptonic heavy -> heavy and heavy -> light meson transitions are studied as a phenomenological application of a heavy-quark limit of Dyson-Schwinger equations. Employing two parameters: E, the difference between the mass of the heavy meson and the effective-mass of the heavy quark; and Lambda, the width of the heavy-meson Bethe-Salpeter amplitude, we calculate f_+(t) for all decays on their entire kinematically accessible t-domain. Our study favours f_B in the range 0.135-0.17 GeV and with E=0.44 GeV and 1/Lambda = 0.14 fm we obtain f_+^{B pi}(0) = 0.46. As a result of neglecting 1/m_c-corrections, we estimate that our calculated values of \rho^2 = 0.87 and f_+^{DK}(0)=0.62 are too low by approximately 15%. However, the bulk of these corrections should cancel in our calculated values of Br(D -> \pi l nu)/Br(D -> K l nu)=0.13 and f_+^{D pi}(0)/f_+^{DK}(0) = 1.16.Comment: 26 pages, 3 figures, REVTE

Decision and Discovery in Defining “Disease”

This version (May 17, 2005) was published in its final form as: Schwartz PH. Decision and discovery in defining 'disease'. In: Kincaid H, McKitrick J, editors. Establishing medical reality: essays in the metaphysics and epistemology of biomedical science. Dordrecht: Springer; 2007. p. 47-63. http://dx.doi.org/10.1007/1-4020-5216-2_5The debate over how to analyze the concept of disease has often centered on the question of whether to include a reference to values, in particular the ‘disvalue’of diseases, or whether to avoid such notions. ‘Normativists,’such as King ([1954], 1981) and Culver and Gert (1982) emphasize the undesirability of diseases, while ‘Naturalists,’ most prominently Christopher Boorse (1977, 1987, 1997), instead require just the presence of biological dysfunction. The debate between normativism and naturalism often deteriorates into stalemate, with each side able to point out significant problems with the other. It starts to look as if neither approach can work. In this paper, I argue that the standoff stems from deeply questionable assumptions that have been used to formulate the opposing positions and guide the debate. In the end, I propose an alternative set of guidelines that offer a more constructive way to devise and compare theories

Analysis of hadronic invariant mass spectrum in inclusive charmless semileptonic B decays

We make an analysis of the hadronic invariant mass spectrum in inclusive charmless semileptonic B meson decays in a QCD-based approach. The decay width is studied as a function of the invariant mass cut. We examine their sensitivities to the parameters of the theory. The theoretical uncertainties in the determination of $|V_{ub}|$ from the hadronic invariant mass spectrum are investigated. A strategy for improving the theoretical accuracy in the value of $|V_{ub}|$ is described.Comment: 13 pages, 5 Postscript figure

Non-leptonic B decays involving tensor mesons

Two-body non-leptonic decays of B mesons into PT and VT modes are calculated using the non-relativistic quark model of Isgur et al.. The predictions obtained for $B \to \pi D^*_2, \rho D_2^*$ are a factor of $3\sim 5$ below present experimental upper limits. Interesting patterns are obtained for ratios of B decays involving mesons with different spin excitations and their relevance for additional tests of forms factor models are briefly discussed.Comment: 11 pages, Latex, to appear in Phys. Rev.

The Rho GDI Rdi1 regulates Rho GTPases by distinct mechanisms

© 2008 by The American Society for Cell Biology. Under the License and Publishing Agreement, authors grant to the general public, effective two months after publication of (i.e.,. the appearance of) the edited manuscript in an online issue of MBoC, the nonexclusive right to copy, distribute, or display the manuscript subject to the terms of the Creative Commons–Noncommercial–Share Alike 3.0 Unported license (http://creativecommons.org/licenses/by-nc-sa/3.0).The small guanosine triphosphate (GTP)-binding proteins of the Rho family are implicated in various cell functions, including establishment and maintenance of cell polarity. Activity of Rho guanosine triphosphatases (GTPases) is not only regulated by guanine nucleotide exchange factors and GTPase-activating proteins but also by guanine nucleotide dissociation inhibitors (GDIs). These proteins have the ability to extract Rho proteins from membranes and keep them in an inactive cytosolic complex. Here, we show that Rdi1, the sole Rho GDI of the yeast Saccharomyces cerevisiae, contributes to pseudohyphal growth and mitotic exit. Rdi1 interacts only with Cdc42, Rho1, and Rho4, and it regulates these Rho GTPases by distinct mechanisms. Binding between Rdi1 and Cdc42 as well as Rho1 is modulated by the Cdc42 effector and p21-activated kinase Cla4. After membrane extraction mediated by Rdi1, Rho4 is degraded by a novel mechanism, which includes the glycogen synthase kinase 3β homologue Ygk3, vacuolar proteases, and the proteasome. Together, these results indicate that Rdi1 uses distinct modes of regulation for different Rho GTPases.Deutsche Forschungsgemeinschaf