871 research outputs found

    The integration of on-line monitoring and reconfiguration functions using IEEE1149.4 into a safety critical automotive electronic control unit.

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    This paper presents an innovative application of IEEE 1149.4 and the integrated diagnostic reconfiguration (IDR) as tools for the implementation of an embedded test solution for an automotive electronic control unit, implemented as a fully integrated mixed signal system. The paper describes how the test architecture can be used for fault avoidance with results from a hardware prototype presented. The paper concludes that fault avoidance can be integrated into mixed signal electronic systems to handle key failure modes

    The mechanical effects of extracorporeal irradiation on bone

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    Extracorporeal irradiation of an excised tumour-bearing segment of bone followed by its reimplantation is a technique used in bone sarcoma surgery for limb salvage when the bone is of reasonable quality. There is no agreement among previous studies about the dose of irradiation to be given: up to 300 Gy have been used. We investigated the influence of extracorporeal irradiation on the elastic and viscoelastic properties of bone. Bone was harvested from mature cattle and subdivided into 13 groups: 12 were exposed to increasing levels of irradiation: one was not and was used as a control. The specimens, once irradiated, underwent mechanical testing in saline at 37°C. The mechanical properties of each group, including Young's modulus, storage modulus and loss modulus, were determined experimentally and compared with the control group. There were insignificant changes in all of these mechanical properties with an increasing level of irradiation. We conclude that the overall mechanical effect of high levels of extracorporeal irradiation (300 Gy) on bone is negligible. Consequently the dose can be maximised to reduce the risk of local tumour recurrence

    MEMS Piezoelectric Energy Harvester Powered Wireless Sensor Module Driven by Noisy Base Excitation

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    Despite recent advances in MEMS vibration energy harvesting and ultra-low power wireless sensors, designing a wireless sensor system entirely powered by a single MEMS device under noisy base excitation has remained a challenge. This paper presents a wireless sensor system co-integrated with a single MEMS piezoelectric vibration energy harvester chip excited by band-limited large amplitude noisy vibration characteristic of an automotive application. The use of soft stoppers in the MEMS package enables the harvesters to operate at an excitation level of 10 g(rms). A custom thick AlN (Aluminum Nitride) piezoelectric process is employed to fabricate the MEMS harvesters with a single MEMS chip generating 179 ÎźW rectified power under these excitation conditions. A low-power wireless sensor module and a receiver module were also designed and demonstrated in this work. Experiments show that the wireless sensor module can be powered solely by the MEMS energy harvester commencing from the cold state. Successful wireless data transmission and receival of sensor data packets are recorded under representative conditions

    A role for topoisomerase IIÎą in the formation of radiation-induced chromatid breaks

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    Chromatid breaks in cells exposed to low dose irradiation are thought to be initiated by DNA double-strand breaks (DSB), and the frequency of chromatid breaks has been shown to increase in DSB rejoining deficient cells. However, the underlying causes of the wide variation in frequencies of G2 chromatid breaks (or chromatid ‘radiosensitivity') in irradiated T-lymphocytes from different normal individuals and cancer cases are as yet unclear. Here we report evidence that topoisomerase IIα expression level is a factor determining chromatid radiosensitivity. We have exposed the promyelocytic leukaemic cell line (HL60) and two derived variant cell lines (MX1 and MX2) that have acquired resistance to mitoxantrone and low expression of topoisomerase II α, to low doses of γ-radiation and scored the induced chromatid breaks. Chromatid break frequencies were found to be significantly lower in the variant cell lines, compared with their parental HL60 cell line. Rejoining of DSB in the variant cell lines was similar to that in the parental HL60 strain. Our results indicate the indirect involvement of topoisomerase IIα in the formation of radiation-induced chromatid breaks from DSB, and suggest topoisomerase IIα as a possible factor in the inter-individual variation in chromatid radiosensitivity

    The mechanical effect of extracorporeal irradiation on bone

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    Extracorporeal irradiation and re-implantation of a bone segment is a technique employed in bone sarcoma surgery for limb salvage in the setting of reasonable bone stock. There is neither consensus nor rationale given for the dosage of irradiation used in previous studies, with values of up to 300Gy applied. We investigated the influence of extracorporeal irradiation on the elastic and viscoelastic properties of bone. Bone specimens were extracted from mature cattle and subdivided into thirteen groups; twelve groups exposed to increasing levels of irradiation and a control group. The specimens, once irradiated, underwent mechanical testing in saline at 37˚C. Mechanical properties were calculated by experimental means which included Young’s Modulus, Poisson’s Ratio, Dissipation Factor, Storage Modulus, Loss Modulus and Dynamic Modulus. These were all obtained for comparison of the irradiated specimens to the control group. We found that the overall effect of increasing irradiation doses up to 300Gy seems to present negligible change, albeit negative, on the behavior of bone. However, the increase in Poisson’s ratio following extracorporeal irradiation treatment was statistically significant. Therefore, it is concluded that the overall mechanical effect of high levels of extracorporeal irradiation (300Gy) is minute, and could be administered to reduce the risk of malignancy recurrence

    Videoconference-based creativity workshops for mental health staff during the COVID-19 pandemic

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    Background COVID-19 presented significant challenges to psychiatric staff, while social distancing and remote working necessitated digital communications. NHS England prioritised staff wellbeing. Arts-based creativity interventions appear to improve psychological wellbeing, so this study evaluated online Creativity Workshops as a staff support response for COVID-19-related stress. Methods Participants were staff from a South London NHS psychiatric hospital. Group Creativity Workshops were facilitated via Microsoft Teams. Acceptability data on pre- and post-workshop mood and attitudes were self-reported by participants. Feasibility data were gathered from adherence to number of workshop components delivered. Results Eight workshops were delivered in May-September 2020 (N = 55) with high adherence to components. Participants reported significantly increased positive mood and attitudes towards themselves and others; and decreased stress and anxiety. Conclusions Online Creativity Workshops appear feasible and acceptable in reducing stress in psychiatric staff. Integrating a programme of Creativity Workshops within healthcare staff support may benefit staff wellbeing
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