Fetal heterotaxy with tricuspid atresia, pulmonary atresia, and isomerism of the right atrial appendages at 22 weeks.

We report the accurate prenatal diagnosis at 22 weeks gestation of right atrial isomerism in association with tricuspid atresia. Several distinctive sonographic features of isomerism of the right atrial appendages were present in this fetus: complex cardiac abnormality, ventriculoarterial discordance, juxtaposition of the aorta and the inferior vena cava to the right side, pulmonary atresia, and anomalous pulmonary venous return to the morphological right atrium. Tricuspid atresia, which is an extremely rare lesion within heterotaxy spectrum disorders, was present. Postnatal investigations confirmed all prenatally diagnosed abnormalities, with additional findings of pulmonary atresia with discontinuous pulmonary arteries and bilateral arterial ducts, asplenia, and bilateral eparterial bronchi. To our knowledge, tricuspid atresia in the setting of isomerism of the right atrial appendages has not previously been diagnosed or reported prenatally. Because of the complexity of cardiac lesions that may be present in cases of atrial isomerism, these disorders should be considered even if sonographic findings are uncommon or atypical

Re-examining Competition and Education in Collegiate Forensics: Establishing the Need for a Pedagogical Prerogative Perspective

The authors examine the dominant metaphors used to guide collegiate forensics practice during the last four decades. The interplay between education and competition serve as a focus for the analysis. The authors establish the need for a pedagogical prerogative perspective as a means of enhancing the educational value of intercollegiate individual events

Strategies for parental identification and effective parenting of the gifted child

Major studies conducted over the past twenty years have shown that parents are important educators of their children and that not even the best schools can do the Job alone (Walberg, 1984). This is true for parents of gifted children as well. The family often has been cited as one of the most important components in the translation of talent and ability into achievement for gifted children (Olszewski, Kulieka, & Buescher, 1987). Researchers in the field of gifted education generally agree on the importance the family plays in the educational and social development of gifted children (Zorman, 1982)

WHAT WE ARE TRYING TO TEACH Reconnecting Collegiate Forensics to the Communication Discipline

SPECIAL REPORT: National Forensic Association Report on Pedagogy —2010. The document features descriptive analysis of prerogatives for collegiate forensics pedagogy organized in two tiers. Each section is fashioned as a series of “statements of purpose.” The term purpose, in this regard, is related to roots and motivations for teaching. This document recognizes the shaping of best practices in forensics pedagogy as a central goal for the collegiate forensics community. The full measure of the components in each tier work to shape the purpose of teaching and coaching practices that resist replication of past performances and move toward speechmaking and performance development founded in the root principles and rhetorical foundations celebrated in the scholarly and professional study of human communication. A third tier that would address each event individually is strongly suggested during the course of future development

Consumers and Food Price Inflation

This report is divided into five sections that cover the following: major economic concepts underlying consumer food behavior; descriptions how U.S. food price inflation rates have evolved since 1915, when federal price data collection for inflation-measuring purposes began; information on recent history and projections for U.S. food expenditure shares relative to total household budget; an examination of retail food price inflation; and a discussion on the impact that rapid food price inflation can have on government food programs and the more vulnerable consumer groups

The very large G-protein coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles

Sensory hair bundles in the inner ear are composed of stereocilia that can be interconnected by a variety of different link types, including tip links, horizontal top connectors, shaft connectors, and ankle links. The ankle link antigen is an epitope specifically associated with ankle links and the calycal processes of photoreceptors in chicks. Mass spectrometry and immunoblotting were used to identify this antigen as the avian ortholog of the very large G-protein-coupled receptor VLGR1, the product of the Usher syndrome USH2C (Mass1) locus. Like ankle links, Vlgr1 is expressed transiently around the base of developing hair bundles in mice. Ankle links fail to form in the cochleae of mice carrying a targeted mutation in Vlgr1 (Vlgr1/del7TM), and the bundles become disorganized just after birth. FM1-43 [N-(3-triethylammonium)propyl)-4-(4-(dibutylamino)styryl) pyridinium dibromide] dye loading and whole-cell recordings indicate mechanotransduction is impaired in cochlear, but not vestibular, hair cells of early postnatal Vlgr1/del7TM mutant mice. Auditory brainstem recordings and distortion product measurements indicate that these mice are severely deaf by the third week of life. Hair cells from the basal half of the cochlea are lost in 2-month-old Vlgr1/del7TM mice, and retinal function is mildly abnormal in aged mutants. Our results indicate that Vlgr1 is required for formation of the ankle link complex and the normal development of cochlear hair bundles

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

extends lifespan in mice, possibly by delaying aging. Whether inhibition of the mTOR pathway would delay or prevent age-associated disease such as AD remained to be determined. and block or delay AD in mice. As expected from the inhibition of mTOR, autophagy was increased in neurons of rapamycin-treated transgenic, but not in non-transgenic, PDAPP mice, suggesting that the reduction in Aβ and the improvement in cognitive function are due in part to increased autophagy, possibly as a response to high levels of Aβ.Our data suggest that inhibition of mTOR by rapamycin, an intervention that extends lifespan in mice, can slow or block AD progression in a transgenic mouse model of the disease. Rapamycin, already used in clinical settings, may be a potentially effective therapeutic agent for the treatment of AD

Automated identification of elemental ions in macromolecular crystal structures.

Many macromolecular model-building and refinement programs can automatically place solvent atoms in electron density at moderate-to-high resolution. This process frequently builds water molecules in place of elemental ions, the identification of which must be performed manually. The solvent-picking algorithms in phenix.refine have been extended to build common ions based on an analysis of the chemical environment as well as physical properties such as occupancy, B factor and anomalous scattering. The method is most effective for heavier elements such as calcium and zinc, for which a majority of sites can be placed with few false positives in a diverse test set of structures. At atomic resolution, it is observed that it can also be possible to identify tightly bound sodium and magnesium ions. A number of challenges that contribute to the difficulty of completely automating the process of structure completion are discussed

Graphical tools for macromolecular crystallography in PHENIX.

A new Python-based graphical user interface for the PHENIX suite of crystallography software is described. This interface unifies the command-line programs and their graphical displays, simplifying the development of new interfaces and avoiding duplication of function. With careful design, graphical interfaces can be displayed automatically, instead of being manually constructed. The resulting package is easily maintained and extended as new programs are added or modified