203 research outputs found

    Behaving disgracefully: the impact of internet dating site use upon the identities of women in middle age

    Get PDF
    This is a qualitative study that explores the experiences of a group of thirty middle- aged women who, after the loss of a long-term relationship, were using Internet dating sites to find heterosexual relationships and enjoy casual nights out. The research follows women on their journey through their experiences of using dating sites, interacting with men online, and eventually meeting men for offline encounters. The central theme of the thesis is the ways in which women understood and negotiated their identities as single, middle-aged women and how they incorporated often sudden and unexpected change into a linear life story of the self. Central to identity construction were issues of the ageing self over time, sexuality and femininity (and the intersection of all three), which were brought into sharp focus for women entering the dating scene in the middle years. Their experiences of interacting with men, both on and off the dating sites, reveals how women understood, circumvented and challenged heterosexual norms of behaviour and sexuality for the middle-aged woman that were perceived to regulate and restrict their behaviour and use of social space. Importantly however, alongside women's accounts of empowerment as single women sat the almost compulsive desire for male company that fuelled their intensive use of the dating sites. Women were enabled by the dating sites to have many new adventures, date a wide variety of men and enjoy many sexual encounters. This change in behaviour was often perceived as a fundamental challenge to the self as many women understood their dating behaviour as 'acting out of character'. The research shows however, that despite the risk of being placed as 'unrespectable' in the eyes of others, women nevertheless embraced their opportunity to behave 'disgracefully'

    CERN UNIX user guide

    Get PDF

    STEM II Initiative-Updates from Participating Institutions (Part 1)

    Get PDF
    STEM II Initiative – Updates from Participating Institutions (Part 1) is made up of a series of “sampler sessions” so that interested individuals can get an overview but not comprehensive coverage. Dr. Nathan Moon will introduce this session by telling a few important lessons gleaned from the STEM I evaluations. Second, Dr. Tim Howard will talk about the STEM II Initiative at Columbus State. Third, Dr. Judy Awong-Taylor will provide information concerning the STEM II Initiative at Georgia Gwinnett College. Fourth, Dr. Rosalie Richards will discuss what is happening with the STEM II Initiative at Georgia College & State University

    Language Assessment in a Snap: Monitoring Progress Up to 36 Months

    Get PDF
    This article describes the development and validation of the Developmental Snapshot, a 52-item parent questionnaire on child language and vocal communication development that can be administered monthly and scored automatically. The Snapshot was created to provide an easily administered monthly progress monitoring tool that enables parents to better recognize language milestones and offers professionals prompt information to fine-tune intervention strategies. Initial items were piloted by 15 families; refinement and further development of the instrument was conducted with parents of 308 typically developing children. Reliability and criterion validity metrics were examined on subsets of approximately 60 children who completed the Snapshot on a monthly basis and who were evaluated on standard assessments administered by speech language pathologists (SLPs). Divergent validity was also examined for samples of children diagnosed with language delays related to autism spectrum disorder (ASD) (n = 77) or not (n = 49). Results supported the criterion validity (r = .67–.97) and test–retest reliability claims of the Snapshot (r = .95). Sensitivity and specificity for language delay detection also were good at 87%. Potential applications for progress monitoring, fidelity of intervention, and enhancing parents’ awareness of their child’s language and vocal communication changes are discussed

    Probing folded and unfolded states of outer membrane protein a with steady-state and time-resolved tryptophan fluorescence

    Get PDF
    Steady-state and time-resolved fluorescence measurements on each of five native tryptophan residues in full-length and truncated variants of E. coli outer-membrane protein A (OmpA) have been made in folded and denatured states. Tryptophan singlet excited-state lifetimes are multiexponential and vary among the residues. In addition, substantial increases in excited-state lifetimes accompany OmpA folding, with longer lifetimes in micelles than in phospholipid bilayers. This finding suggests that the Trp environments of OmpA folded in micelles and phospholipid bilayers are different. Measurements of Trp fluorescence decay kinetics with full-length OmpA folded in brominated lipid vesicles reveal that W102 is the most distant fluorophore from the hydrocarbon core, while W7 is the closest. Steady-state and time-resolved polarized fluorescence measurements indicate reduced Trp mobility when OmpA is folded in a micelle, and even lower mobility when the protein is folded in a bilayer. The fluorescence properties of truncated OmpA, in which the soluble periplasmic domain is removed, only modestly differ from those of the full-length form, suggesting similar folded structures for the two forms under these conditions

    Research Brief No. 1 - Social Inclusion of the Oldest-Old: Toward Supportive Housing Policies

    Get PDF
    Although most seniors aged 85+ live relatively independently in the community, research on this age group tends to focus on the negative aspects of aging. This study looks instead at seniors aged 85 and older who are living well and semi-independently in their communities with the help of an informal care provider. The study aims to identify the mechanisms that allow them to live with dignity and autonomy in their own homes and remain socially included in their communities. We conducted in-depth, semi-structured interviews with 16 individuals aged 85 to 94 years and their primary informal support-persons in Southwestern Ontario, from Hamilton to Chatham. The result is evidence-based information about how the “oldest-old” and their caregivers manage to overcome problems seniors experience with daily tasks such as mobility, transportation and cooking. The research identifies optimal environments in which these “caring relationships” can be sustained and in which seniors can flexibly manage daily life and continue to stay in their own homes

    Cardiomyopathy confers susceptibility to particulate matter-induced oxidative stress, vagal dominance, arrhythmia and pulmonary inflammation in heart failure-prone rats

    Get PDF
    Acute exposure to ambient fine particulate matter (PM2.5) is tied to cardiovascular morbidity and mortality, especially among those with prior cardiac injury. The mechanisms and pathophysiologic events precipitating these outcomes remain poorly understood but may involve inflammation, oxidative stress, arrhythmia, and autonomic nervous system imbalance. Cardiomyopathy results from cardiac injury, is the leading cause of heart failure, and can be induced in heart failure-prone rats through sub-chronic infusion of isoproterenol (ISO). To test whether cardiomyopathy confers susceptibility to inhaled PM2.5 and can elucidate potential mechanisms, we investigated the cardiophysiologic, ventilatory, inflammatory, and oxidative effects of a single nose-only inhalation of a metal-rich PM2.5 (580 ÎĽg/m3, 4h) in ISO-pretreated (35 days * 1.0 mg/kg/day sc) rats. During the 5 days post-treatment, ISO-treated rats had decreased HR and BP and increased pre-ejection period (PEP, an inverse correlate of contractility) relative to saline-treated rats. Before inhalation exposure, ISO-pretreated rats had increased PR and ventricular repolarization time (QT) and heterogeneity (Tp-Te). Relative to clean air, PM2.5 further prolonged PR-interval and decreased systolic BP during inhalation exposure; increased tidal volume, expiratory time, heart rate variability (HRV) parameters of parasympathetic tone, and atrioventricular block arrhythmias over the hours post-exposure; increased pulmonary neutrophils, macrophages, and total antioxidant status one day post-exposure; and decreased pulmonary glutathione peroxidase 8 weeks after exposure, with all effects occurring exclusively in ISO-pretreated rats but not saline-pretreated rats. Ultimately, our findings indicate that cardiomyopathy confers susceptibility to the oxidative, inflammatory, ventilatory, autonomic, and arrhythmogenic effects of acute PM2.5 inhalation

    Acute Ozone-Induced Pulmonary and Systemic Metabolic Effects Are Diminished in Adrenalectomized Rats

    Get PDF
    Acute ozone exposure increases circulating stress hormones and induces metabolic alterations in animals. We hypothesized that the increase of adrenal-derived stress hormones is necessary for both ozone-induced metabolic effects and lung injury. Male Wistar-Kyoto rats underwent bilateral adrenal demedullation (DEMED), total bilateral adrenalectomy (ADREX), or sham surgery (SHAM). After a 4 day recovery, rats were exposed to air or ozone (1 ppm), 4 h/day for 1 or 2 days and responses assessed immediately postexposure. Circulating adrenaline levels dropped to nearly zero in DEMED and ADREX rats relative to SHAM. Corticosterone tended to be low in DEMED rats and dropped to nearly zero in ADREX rats. Adrenalectomy in air-exposed rats caused modest changes in metabolites and lung toxicity parameters. Ozone-induced hyperglycemia and glucose intolerance were markedly attenuated in DEMED rats with nearly complete reversal in ADREX rats. Ozone increased circulating epinephrine and corticosterone in SHAM but not in DEMED or ADREX rats. Free fatty acids (P = .15) and branched-chain amino acids increased after ozone exposure in SHAM but not in DEMED or ADREX rats. Lung minute volume was not affected by surgery or ozone but ozone-induced labored breathing was less pronounced in ADREX rats. Ozone-induced increases in lung protein leakage and neutrophilic inflammation were markedly reduced in DEMED and ADREX rats (ADREX > DEMED). Ozone-mediated decreases in circulating white blood cells in SHAM were not observed in DEMED and ADREX rats. We demonstrate that ozone-induced peripheral metabolic effects and lung injury/inflammation are mediated through adrenal-derived stress hormones likely via the activation of stress response pathway

    Senior Recital: Thomas Kieffer, alto saxophone and Tyler Elvidge, trumpet

    Get PDF
    This recital is presented in partial fulfillment of requirements for the degrees Bachelor of Music in Music Education. Mr. Kieffer studies saxophone with Sam Skelton. Mr. Elvidge studies trumpet with Douglas Lindsey.https://digitalcommons.kennesaw.edu/musicprograms/1179/thumbnail.jp
    • …
    corecore