Sharing Englishes & Social Media

This year-long grant-funded project examined the intersection of culture and class with use of the English Language, and explored the concept of multiple Englishes rather than one, monolithic, correct version of the language

Accretion onto endoparasitic black holes at the center of neutron stars

We revisit the system consisting of a neutron star that harbors a small, possibly primordial, black hole at its center, focusing on a nonspinning black hole embedded in a nonrotating neutron star. Extending earlier treatments, we provide an analytical treatment describing the rate of secular accretion of the neutron star matter onto the black hole, adopting the relativistic Bondi accretion formalism for stiff equations of state that we presented elsewhere. We use these accretion rates to sketch the evolution of the system analytically until the neutron star is completely consumed. We also perform numerical simulations in full general relativity for black holes with masses up to nine orders of magnitude smaller than the neutron star mass, including a simulation of the entire evolution through collapse for the largest black hole mass. We construct relativistic initial data for these simulations by generalizing the black hole puncture method to allow for the presence of matter, and evolve these data with a code that is optimally designed to resolve the vastly different length scales present in this problem. We compare our analytic and numerical results, and provide expressions for the lifetime of neutron stars harboring such endoparasitic black holes

Marine inspired textured materials for reduction of biofouling on surfaces

Biofouling on deployed in-situ sensors without regular removal or cleaning can disrupt sensor data collected. The current replacement antifouling (AF) materials under development are largely unsuited to sensor technologies as they have been developed with large scale applications in mind, such as those required by the shipping industry. Therefore, a strategy for the development of novel, sustainable, antifouling materials for sensor applications is required. Bio-inspiration refers to adapting strategies already developed in the natural world to problems encountered in modern science and technology. Engineered surfaces capable of controlling cellular behaviour under natural conditions are challenging to design due to the diversity of attaching cell types in environments such as marine waters, where many variations in cell shape, size and adhesion strategy exist. Nevertheless, understanding interactions between a cell and a potential substrate for adhesion, including topographically driven settlement cues, offers a route to designing surfaces capable of controlling cell settlement. Biomimetic design of artificial surfaces, based upon microscale features from natural surfaces, can be utilized as model surfaces to understand cell-surface interactions. In this study it was hypothesized that an AF effect could be induced through the replication of a synthetic surface. Scophthalmus rhombus (Brill) is a small flatfish occurring in marine waters of the Mediterranean as well as in Norway and Iceland. It inhabits sandy and muddy coastal waters from 5 to 80 metres. Its skin changes colour depending on the environment but is generally brownish with light and dark freckles and a creamy underside. S. rhombus is oval in shape and its flesh is white[1], [2]. In this study, the micro topography of the brill scale is characterized for the first time which may serve as a trend for the design of a marine inspired biomimetic surface texture. Natural dermal scales of S. rhombus are artificially replicated using 3-D printing and mould casting technologies. The replication methods are then tested for initial colonization of fouling species using 3 h immersion testing using diatom species, CCAP 1052/1B, Phaeodactylum tricornutum. The aim of this study was to discover the potential of using textured surfaces inspired by nature in particular marine organisms to combat fouling. This work identifies simple textures that can reduce fouling in its early stages which can contribute to antifouling coatings on sensors for monitoring in the marine environment

Delayed effects of a 20-min crushed ice application on knee joint position sense assessed by a functional task during a re-warming period

Delayed effects of a 20-minute crushed ice application on knee joint position sense assessed by a functional task during a re-warming period. Introduction The effect of cryotherapy on joint positioning presents conflicting debates as to whether individuals are at an increased risk of injury when returning to play following cryotherapy application at the lower limb. Objectives The aim of this study was to investigate whether a 20 minute application of crushed ice at the knee affects knee joint position sense immediately post and up to 20 mins post ice removal, during a small knee bend. Method 17 healthy male participants took part in the study performing a functional task. Using three-dimensional motion analysis (Qualisys Medical AB Gothenburg, Sweden), kinematics of the knee were measured during a weight bearing functional task pre and immediately post, 5, 10, 15 and 20 minutes post cryotherapy intervention. Skin surface temperature (Tsk) cooling was measured via infrared non-contact thermal imaging (Flir Systems, Danderyd, Sweden) over the anterior and medial aspect of the knee. Results Results demonstrated significant reductions in the ability to accurately replicate knee joint positioning. A significant increase (P ≧ 0.05) in rotational movement in the transverse plane occurred, 20 minutes post ice removal. Discussion A 20-minute application of crushed ice to the anterior aspect of the non-dominant knee has an adverse effect on knee joint repositioning and dynamic stability, 20 minutes after ice is removed. In consideration of returning a land-based athlete to dynamic functional activities, post cryotherapeutic intervention at the knee, clinicians should consider these findings due to the potential increase risk of injur

Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections

MASP-2, mannose-binding protein-associated serine protease 2, is a key enzyme in the lectin pathway of complement activation. Hyperactivation of this protein by human coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2 has been found to contribute to aberrant complement activation in patients, leading to aggravated lung injury with potentially fatal consequences. This hyperactivation is triggered in the lungs through a conserved, direct interaction between MASP-2 and coronavirus nucleocapsid (N) proteins. Blocking this interaction with monoclonal antibodies and interfering directly with the catalytic activity of MASP-2, have been found to alleviate coronavirus-induced lung injury both in vitro and in vivo. In this study, a virtual library of 8736 licensed drugs and clinical agents has been screened in silico according to two parallel strategies. The first strategy aims at identifying direct inhibitors of MASP-2 catalytic activity, while the second strategy focusses on finding protein-protein interaction inhibitors (PPIs) of MASP-2 and coronaviral N proteins. Such agents could represent promising support treatment options to prevent lung injury and reduce mortality rates of infections caused by both present and future-emerging coronaviruses. Forty-six drug repurposing candidates were purchased and, for the ones selected as potential direct inhibitors of MASP-2, a preliminary in vitro assay was conducted to assess their interference with the lectin pathway of complement activation. Some of the tested agents displayed a dose-response inhibitory activity of the lectin pathway, potentially providing the basis for a viable support strategy to prevent the severe complications of coronavirus infections

Associations Between Left Ventricular Dysfunction and Brain Structure and Function: Findings From the SABRE (Southall and Brent Revisited) Study

Background Subclinical left ventricular (LV) dysfunction has been inconsistently associated with early cognitive impairment, and mechanistic pathways have been poorly considered. We investigated the cross‐sectional relationship between LV dysfunction and structural/functional measures of the brain and explored the role of potential mechanisms. Method and Results A total of 1338 individuals (69±6 years) from the Southall and Brent Revisited study underwent echocardiography for systolic (tissue Doppler imaging peak systolic wave) and diastolic (left atrial diameter) assessment. Cognitive function was assessed and total and hippocampal brain volumes were measured by magnetic resonance imaging. Global LV function was assessed by circulating N‐terminal pro–brain natriuretic peptide. The role of potential mechanistic pathways of arterial stiffness, atherosclerosis, microvascular disease, and inflammation were explored. After adjusting for age, sex, and ethnicity, lower systolic function was associated with lower total brain (beta±standard error, 14.9±3.2 cm3; P<0.0001) and hippocampal volumes (0.05±0.02 cm3, P=0.01). Reduced diastolic function was associated with poorer working memory (−0.21±0.07, P=0.004) and fluency scores (−0.18±0.08, P=0.02). Reduced global LV function was associated with smaller hippocampal volume (−0.10±0.03 cm3, P=0.004) and adverse visual memory (−0.076±0.03, P=0.02) and processing speed (0.063±0.02, P=0.006) scores. Separate adjustment for concomitant cardiovascular risk factors attenuated associations with hippocampal volume and fluency only. Further adjustment for the alternative pathways of microvascular disease or arterial stiffness attenuated the relationship between global LV function and visual memory. Conclusions In a community‐based sample of older people, measures of LV function were associated with structural/functional measures of the brain. These associations were not wholly explained by concomitant risk factors or potential mechanistic pathways

Bio-inspired surface texture modification as a viable feature of future aquatic antifouling strategies: a review

The imitation of natural systems to produce effective antifouling materials is often referred to as “biomimetics”. The world of biomimetics is a multidisciplinary one, needing careful understanding of “biological structures”, processes and principles of various organisms found in nature and based on this, designing nanodevices and nanomaterials that are of commercial interest to industry. Looking to the marine environment for bioinspired surfaces offers researchers a wealth of topographies to explore. Particular attention has been given to the evaluation of textures based on marine organisms tested in either the laboratory or the field. The findings of the review relate to the numbers of studies on textured surfaces demonstrating antifouling potential which are significant. However, many of these are only tested in the laboratory, where it is acknowledged a very different response to fouling is observed

A Low-cost Novel Optical Sensor for In Situ Water Quality Monitoring

With increasing environmental pressure due to global climate change, increases in global population and the need for sustainable obtained resources, water resources management is critical. In-situ sensors are fundamental to the management of water systems by providing early warning, forecasting and baseline data to stakeholders. To be fit-for-purpose, monitoring using in-situ sensors has to be carried out in a cost effective way and allow implementation at larger spatial scales. If networks of sensors are to become not only a reality but common place, it is necessary to produce reliable, inexpensive, rugged sensors integrated with data analytics. In this context, the aim of this project was to design and develop a low cost, robust and reliable optical sensor which capable of continuous measurement of chemical and physical parameters in aquatic environments. An iterative engineering design method cycling between sensor design, prototyping and testing was used for the realisation and optimisation of the sensor. The sensor can provide absorption, scatter, and fluorescence readings over a broad spectral range (280nm to 850nm) and temperature readings in real-time using a suite of optical sensors (CMOS Spectrometers and photodiode detector), custom designed LED array light source and a digital temperature probe. Custom electronics and firmware were developed to control the sensor and facilitate data transmission to an external network. Sensor electronics are housed in a marine grade watertight housing; the optical components are mounted inside a custom designed 3D-printed optical head which joins with the sensor housing. The sensor is capable of measuring a range of optical parameters and temperature in a single measurement cycle. Sensor analytical performance was demonstrated in the laboratory, for detection and quantification of turbidity using analytical standards and in the field by comparison with a commercially available multi- parameter probe (YSI, EXO 2). The laboratory and field trials demonstrate that the sensor is fit-for-purpose and an excellent tool for early warning monitoring by providing high frequency time-series data, operate unattended in-situ for extended periods of times and capture pollution events

A study of the SOURCE-TO-SEA occurrence of poly- and perfluoroalkyl substances (PFASs) of emerging concern in Ireland

Perfluorinated compounds are ubiquitous. Approximately 4,700 PFAS have been identified to date. Some examples of these products include carpets, glass, paper, clothing, and other textiles, cookware, food packaging, electronics, and personal care products. PFAS have been used in industrial and consumer products since the 1950s due to their physical and chemical properties. PFAS molecules can include oxygen, hydrogen, sulphur, and/or nitrogen atoms, whereas perfluorocarbon molecules contain only carbon and fluorine atoms. Perfluorinated compounds (PFAS) contain a fully fluorinated hydrophobic linear carbon chain attached to one or more hydrophilic head groups. The carbon-fluorine bond is so strong that these chemicals do not degrade in the environment. They are often referred to as ‘forever chemicals’. Some PFAS have been linked to an increased risk of cancer, high cholesterol, reproductive disorders, hormonal disruption or endocrine disruption, and weakening of the immune system. Currently, two PFAS are restricted under the international Stockholm Convention on POPs and the EU POPs Regulation. PFOS (perfluoroctanesulfonic acid) and its derivatives have been restricted since 2009/2010. PFOA (perfluorooctanoic acid), its salts, and related compounds are also regulated as of 4th July 2020. Over the past decades, global manufacturers have started to substitute long-chain PFAS with shorter-chain PFAS or with non-fluorinated substances. This trend has been driven by the fact that the undesired effects of long-chain PFAS on human health and the environment were assessed and recognised first by scientists and authorities around the globe. However short-chain PFAS are now thought to have similar or other properties of concern such as fluorinated compounds like Gen X and ADONA. The combined effects of PFAS are not widely studied and relatively unknown. There is also little biological assessment currently done for drinking water and especially marine water. These are both research gaps, by using biological assessment one can study the cumulative and combined effect of various PFAS on marine species which is what we aim to do in this stud