A Study of Community Interaction

This study analyses selected aspects of the community impact of the Kitsap Community Action Program projects entitled \u27\u27The Public Awareness of Kitsap (PACK). PACK was initiated as a response to a downsizing of Department of Defense activities in Kitsap County. With PACK, the Kitsap Community Action Program (KCAP) joined hands with the Washington Service Corps in an effort funded by the Defense Conversion Assistance program to revitalize the local Bremerton and Kitsap County economies

A randomised controlled trial of the clinical effectiveness and cost-effectiveness of different knee prostheses : the Knee Arthroplasty Trial (KAT)

Peer reviewedPublisher PD

White matter tract integrity in treatment-resistant gambling disorder

Background Gambling disorder is a relatively common psychiatric disorder recently re-classified within the DSM-5 under the category of ‘substance-related and addictive disorders’. Aims To compare white matter integrity in patients with gambling disorder with healthy controls; to explore relationships between white matter integrity and disease severity in gambling disorder. Method In total, 16 participants with treatment-resistant gambling disorder and 15 healthy controls underwent magnetic resonance imaging (MRI). White matter integrity was analysed using tract-based spatial statistics. Results Gambling disorder was associated with reduced fractional anisotropy in the corpus callosum and superior longitudinal fasciculus. Fractional anisotropy in distributed white matter tracts elsewhere correlated positively with disease severity. Conclusions Reduced corpus callosum fractional anisotropy is suggestive of disorganised/damaged tracts in patients with gambling disorder, and this may represent a trait/vulnerability marker for the disorder. Future research should explore these measures in a larger sample, ideally incorporating a range of imaging markers (for example functional MRI) and enrolling unaffected first-degree relatives of patients.This research was supported by a grant from the National Center for Responsible Gaming to Dr. Grant, and by a grant from the Academy of Medical Sciences to Dr. Chamberlain (UK). Dr. Grant has received research grants from NIMH, National Center for Responsible Gaming, and Forest and Roche Pharmaceuticals Dr. Grant receives yearly compensation from Springer Publishing for acting as Editor-in-Chief of the Journal of Gambling Studies and has received royalties from Oxford University Press, American Psychiatric Publishing, Inc., Norton Press, and McGraw Hill. Dr. Chamberlain consults for Cambridge Cognition. Mr. Odlaug has received a research grant from the Trichotillomania Learning Center, consults for H. Lundbeck A/S, and has received royalties from Oxford University Press. Mr. Leppink and Ms. Derbyshire report no conflicts of interest.This is the author accepted manuscript. The final version is available from the Royal College of Psychiatrists via http://dx.doi.org/10.1192/bjp.bp.115.16550

Multi-Scale Characterization of the PEPCK-Cmus Mouse through 3D Cryo-Imaging

We have developed, for the Case 3D Cryo-imaging system, a specialized, multiscale visualization scheme which provides color-rich volume rendering and multiplanar reformatting enabling one to visualize an entire mouse and zoom in to organ, tissue, and microscopic scales. With this system, we have anatomically characterized, in 3D, from whole animal to tissue level, a transgenic mouse and compared it with its control. The transgenic mouse overexpresses the cytosolic form of phosphoenolpyruvate carboxykinase (PEPCK-C) in its skeletal muscle and is capable of greatly enhanced physical endurance and has a longer life-span and reproductive life as compared to control animals. We semiautomatically analyzed selected organs such as kidney, heart, adrenal gland, spleen, and ovaries and found comparatively enlarged heart, much less visceral, subcutaneous, and pericardial adipose tissue, and higher tibia-to-femur ratio in the transgenic animal. Microscopically, individual skeletal muscle fibers, fine mesenteric blood vessels, and intestinal villi, among others, were clearly seen

Stochastic Heterogeneity Mapping as a tool to quantify turbulence in reflectivity layers of thermohaline staircases in the Tyrrhenian Sea

European Geosciences Union General Assembly 2013, 7-12 April 2013, Vienna, AustriaProcessed multi-channel seismic data acquired in the Tyrrhenian Sea in April-May 2010 with the B/O Sarmiento de Gamboa provide images of oceanic thermohaline staircases. Thermohaline staircases are regular, well-defined step-like variations in vertical profiles of temperature and salinity. In the ocean they are thought to be the result of double diffusion driven by the two order of magnitude difference in the diffusivities of heat and salt. Staircases are believed to have an anomalously weak internal wave-induced turbulence, making them suitable for the estimation of a lower limit of turbulent disturbances detectable by multi-channel seismics. We apply stochastic heterogeneity mapping based on the band-limited von Kármán function to post-stack time-migrated seismic data to extract stochastic parameters such as the Hurst number (a measure of reflection interface roughness) and correlation length (scale length). For scale sizes smaller than the correlation length, the von Kármán model describes a power law (fractal) process where the Hurst number is its exponent. We present the results of our analysis corroborated by benchmark tests performed on synthetic seismic data generated from random fractal surfaces. The synthetic tests are found to verify the robustness of the technique. Lower Hurst numbers represent a richer range of high wavenumbers and therefore correspond to a broader range of heterogeneity in reflection events. We interpret a broader range of heterogeneity as indicative of a greater degree of turbulence. Some areas of the seismic data show a spatial variation in Hurst number across several frequency bands that may indicate some preferential coupling of energy at different depthsPeer Reviewe