12,646 research outputs found
Power Corrections to the Universal Heavy WIMP-Nucleon Cross Section
WIMP-nucleon scattering is analyzed at order in Heavy WIMP Effective
Theory. The power corrections, where is the WIMP mass,
distinguish between different underlying UV models with the same universal
limit and their impact on direct detection rates can be enhanced relative to
naive expectations due to generic amplitude-level cancellations at leading
order. The necessary one- and two-loop matching calculations onto the
low-energy effective theory for WIMP interactions with Standard Model quarks
and gluons are performed for the case of an electroweak SU(2) triplet WIMP,
considering both the cases of elementary fermions and composite scalars. The
low-velocity WIMP-nucleon scattering cross section is evaluated and compared
with current experimental limits and projected future sensitivities. Our
results provide the most robust prediction for electroweak triplet Majorana
fermion dark matter direct detection rates; for this case, a cancellation
between two sources of power corrections yields a small total correction,
and a total cross section close to the universal limit for . For the SU(2) composite scalar, the corrections
introduce dependence on underlying strong dynamics. Using a leading chiral
logarithm evaluation, the total correction has a larger magnitude and
uncertainty than in the fermionic case, with a sign that further suppresses the
total cross section. These examples provide definite targets for future direct
detection experiments and motivate large scale detectors capable of probing to
the neutrino floor in the TeV mass regime.Comment: 12 pages, 4 figures; references added, XENONnT projection included,
version to appear in Physics Letters
Pairs of Noncrossing Free Dyck Paths and Noncrossing Partitions
Using the bijection between partitions and vacillating tableaux, we establish
a correspondence between pairs of noncrossing free Dyck paths of length
and noncrossing partitions of with blocks. In terms of the
number of up steps at odd positions, we find a characterization of Dyck paths
constructed from pairs of noncrossing free Dyck paths by using the Labelle
merging algorithm.Comment: 9 pages, 5 figures, revised version, to appear in Discrete
Mathematic
Photometry and Photometric Redshifts of Faint Galaxies in the Hubble Deep Field South NICMOS Field
We present a catalog of photometry and photometric redshifts of 335 faint
objects in the HDF-S NICMOS field. The analysis is based on (1) infrared images
obtained with the Hubble Space Telescope (HST) using the Near Infrared Camera
and Multi-Object Spectrograph (NICMOS) with the F110W, F160W, and F222M
filters, (2) an optical image obtained with HST using the Space Telescope
Imaging Spectrograph (STIS) with no filter, and (3) optical images obtained
with the European Southern Observatory (ESO) Very Large Telescope (VLT) with U,
B, V, R, and I filters. The primary utility of the catalog of photometric
redshifts is as a survey of faint galaxies detected in the NICMOS F160W and
F222M images. The sensitivity of the survey varies significantly with position,
reaching a limiting depth of AB(16,000) ~ 28.7 and covering 1.01 arcmin^2 to
AB(16,000) = 27 and 1.05 arcmin^2 to AB(16,000) = 26.5. The catalog of
photometric redshifts identifies 21 galaxies (or 6% of the total) of redshift z
> 5, 8 galaxies (or 2% of the total) of redshift z > 10, and 11 galaxies (or 3%
of the total) of best-fit spectral type E/S0, of which 5 galaxies (or 1% of the
total) are of redshift z > 1.Comment: 33 pages, 10 figures, accepted for publication in the Astrophysical
Journal, August 1, 2000 issu
Function of the Signal Peptide and N- and C-terminal Propeptides in the Leucine Aminopeptidase from \u3cem\u3eAeromonas proteolytica\u3c/em\u3e
The leucine aminopeptidase from Aeromonas proteolytica (also known as Vibrio proteolyticus) (AAP) is a metalloenzyme with broad substrate specificity. The open reading frame (ORF) for AAP encodes a 54 kDa enzyme, however, the extracellular enzyme has a molecular weight of 43 kDa. This form of AAP is further processed to a mature, thermostable 32 kDa form but the exact nature of this process is unknown. Over-expression of different forms of AAP in Escherichia coli (with AAP\u27s native leader sequence, with and without the N- and/or C-terminal propeptides, and as fusion protein) has allowed a model for the processing of wild-type AAP to be proposed. The role of the A. proteolytica signal peptide in protein secretion as well as comparison to other known signal peptides reveals a close resemblance of the A. proteolytica signal peptide to the outer membrane protein (OmpA) signal peptide. Over-expression of the full 54 kDa AAP enzyme provides an enzyme that is significantly less active, due to a cooperative inhibitory interaction between both propeptides. Over-expression of AAP lacking its C-terminal propeptide provided an enzyme with an identical kcat value to wild-type AAP but exhibited a larger Km value, suggesting competitive inhibition of AAP by the N-terminal propeptide (KiâŒ0.13 nM). The recombinant 32 kDa form of AAP was characterized by kinetic and spectroscopic methods and was shown to be identical to mature, wild-type AAP. Therefore, the ease of purification and processing of rAAP along with the fact that large quantities can be obtained now allow new detailed mechanistic studies to be performed on AAP through site-directed mutagenesis
Structurally Distinct Active Sites in the Copper(II)-Substituted Aminopeptidases from \u3cem\u3eAeromonas proteolytica\u3c/em\u3e and \u3cem\u3eEscherichia coli\u3c/em\u3e
The aminopeptidase from Aeromonas proteolytica (AAP) was titrated with copper, which bound sequentially at two distinct sites. Both the mono- and disubstituted forms of AAP exhibited catalytic hyperactivity relative to the native dizinc enzyme. Monosubstituted AAP exhibited an axial Cu(II) EPR spectrum with slight pH dependence:â at pH 6.0 g|| = 2.249, gâ„ = 2.055, and A||(63/65Cu) = 1.77 Ă 10-2 cm-1, whereas at pH 9.65 g|| = 2.245, gâ„ = 2.056, and A||(63/65Cu) = 1.77 Ă 10-2 cm-1. These data indicate oxygen and nitrogen ligation of Cu. AAP further substituted with copper exhibited a complex signal with features around g ⌠2 and 4. The features at g ⌠4 were relatively weak in the B0 â„ B1 (perpendicular) mode EPR spectrum but were intense in the B0 || B1 (parallel) mode spectrum. The g ⌠2 region of the perpendicular mode spectrum exhibited two components, one corresponding to mononuclear Cu(II) with g|| = 2.218, gâ„ = 2.023, and A||(63/65Cu) = 1.55 Ă 10-2 cm-1 and likely due to adventitious binding of Cu(II) to a site distant from the active site. Excellent simulations were obtained for the second component of the spectrum assuming that two Cu(II) ions experience dipolar coupling corresponding to an inter-copper distance of 5 Ă
with the two Cu(II) gz directions parallel to each other and at an angle of âŒ17° to the inter-copper vector (â = ÎČB·gCuA·SCuA + ÎČB·gCuB·SCuB + [S·A·I]CuA + [S·A·I]CuB + [SCuA·J·SCuB]; g||(CuA,CuB) = 2.218, gâ„(CuA,CuB) = 2.060; A||(CuA,CuB)(63/65Cu) = 1.59 Ă 10-2 cm-1, Jisotropic = 50 cm-1, rCu-Cu = 4.93 Ă
, and Ï = 17°). The exchange coupling between the two copper ions was found to be ferromagnetic as the signals exhibited Curie law temperature dependence. The CuâCu distance of âŒ5 Ă
indicated by EPR was significantly higher than the inter-zinc distance of 3.5 Ă
in the native enzyme, and the dicopper species therefore represents a novel dinuclear site capable of catalysis of hydrolysis. In contrast to AAP, the related methionyl aminopeptidase from Escherichia coli (EcMetAP) was found to bind only one Cu(II) ion despite possessing a dinuclear binding site motif. A further difference was the marked pH dependence of the signal in EcMetAP, suggestive of a change in ligation. The structural motifs of these two Cu(II)-substituted aminopeptidases provide important insight into the observed catalytic activity
Evaluation of Relative Sensitivity of SAW and Flexural Plate Wave Devices for Atmospheric Sensing
The objective of this project is to evaluate the suitability of the ultrasonic flexural plate wave (FPW) device as the detector in a gas chromatograph (GC). Of particular interest is the detection of nitrous oxide (N2O). From experimental results we conclude analyte detection is achieved through two mechanisms: changes in gas density, and mass loading of the device membrane due to the sorption of gas molecules. Reducing the dead volume of the FPW chamber increased the FPW response. A comparison of the FPW response to that of the surface acoustic wave (SAW) detector provided with the GC (made by MSI, Microsensor Technologies, Inc.), shows that for unseparated N2O in N2, the FPW exhibits a sensitivity that is at least 550 times greater than that of the SAW device. A Porapak Q column was found to separate N2O from its carrier gas, N2 or He. With the Porapak Q column, a coated FPW detected 1 ppm N2O in N2 or He, with a response magnitude of 7 Hz. A coated SAW exhibited a response of 25 Hz to pure N2O. The minimal detectable N2O concentrations of the sensors were not evaluated
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