The nature of X-ray spectral variability in Seyfert Galaxies

We use a model-independent technique to investigate the nature of the 2-15 keV X-ray spectral variability in four Seyfert galaxies and distinguish between spectral pivoting and the two-component model for spectral variability. Our analysis reveals conclusively that the softening of the X-ray continuum with increasing flux in MCG -6-30-15 and NGC 3516 is a result of summing two spectral components: a soft varying component (SVC) with spectral shape independent of flux and a constant hard component (HCC). In contrast, the spectral variability in NGC 4051 can be well described by simple pivoting of one component, together with an additional hard constant component. The spectral variability model for NGC 5506 is ambiguous, due to the smaller range of fluxes sampled by the data. We investigate the shape of the hard spectral component in MCG -6-30-15 and find that it appears similar to a pure reflection spectrum, but requires a large reflected fraction (R>3). We briefly discuss physical interpretations of the different modes of spectral variability.Comment: Accepted for publication in MNRAS letter

Central role for the XRCC1 BRCT I domain in mammalian DNA single-strand break repair

The DNA single-strand break repair (SSBR) protein XRCC1 is required for genetic stability and for embryonic viability. XRCC1 possesses two BRCA1 carboxyl-terminal (BRCT) protein interaction domains, denoted BRCT I and II. BRCT II is required for SSBR during G1 but is dispensable for this process during S/G2 and consequently for cell survival following DNA alkylation. Little is known about BRCT I, but this domain has attracted considerable interest because it is the site of a genetic polymorphism that epidemiological studies have associated with altered cancer risk. We report that the BRCT I domain comprises the evolutionarily conserved core of XRCC1 and that this domain is required for efficient SSBR during both G1 and S/G2 cell cycle phases and for cell survival following treatment with methyl methanesulfonate. However, the naturally occurring human polymorphism in BRCT I supported XRCC1-dependent SSBR and cell survival after DNA alkylation equally well. We conclude that while the BRCT I domain is critical for XRCC1 to maintain genetic integrity and cell survival, the polymorphism does not impact significantly on this function and therefore is unlikely to impact significantly on susceptibility to cancer

FARM-LEVEL RESPONSE TO AGRICULTURAL EFFLUENT CONTROL STRATEGIES: THE CASE OF THE WILLAMETTE VALLEY

This article examines economic incentives and other mechanisms to offset non-point source pollution from agriculture. A biophysical simulator to estimate technical relationships is linked to linear programming models for representative farms in the Willamette Valley of Oregon. The models are then optimized for profit maximization under alternative non-point pollution control policies. The results indicate that site-specific resource conditions and production possibilities greatly influence policy effectiveness and the cost of achieving pollution abatement. Nevertheless, some abatement is possible on all farms for relatively little cost.Environmental Economics and Policy,

Regression-based seasonal unit root tests

The contribution of this paper is three-fold. Firstly, a characterisation theorem of the sub-hypotheses comprising the seasonal unit root hypothesis is presented which provides a precise formulation of the alternative hypotheses against which regression-based seasonal unit root tests test. Secondly, it proposes regressionbased tests for the seasonal unit root hypothesis which allow a general seasonal aspect for the data and are similar both exactly and asymptotically with respect to initial values and seasonal drift parameters. Thirdly, limiting distribution theory is given for these statistics where, in contrast to previous papers in the literature, in doing so it is not assumed that unit roots hold at all of the zero and seasonal frequencies. This is shown to alter the large sample null distribution theory for regression t-statistics for unit roots at the complex frequencies, but interestingly to not affect the limiting null distributions of the regression t-statistics for unit roots at the zero and Nyquist frequencies and regression Fstatistics for unit roots at the complex frequencies. Our results therefore have important implications for how tests of the seasonal unit root hypothesis should be conducted in practice. Associated simulation evidence on the size and power properties of the statistics presented in this paper is given which is consonant with the predictions from the large sample theory.Seasonal unit root tests; seasonal drifts; characterisation theorem

ECONOMIC FEASIBILITY OF THE CATTLE FEEDING INDUSTRY IN THE NORTHERN PLAINS AND WESTERN LAKES STATES - SUMMARY

The five-state study area of the Northern Plains and Western Lakes States, Minnesota, Montana, North Dakota, South Dakota, and Wisconsin, has adequate feed supplies and feeder cattle to markedly increase cattle feeding. Feed costs in these states have historically been lower than in the Southern Plains States. However, higher transportation costs appear to offset that advantage. Close access to slaughter plants in these states could offset that transportation disadvantage. Backgrounding of cattle appears to be quite profitable and cattle feeding, especially in larger sized feedlots, can be profitable. However, the cattle feeding industry has an increasing level of excess capacity. To be successful, new feedlots in the Northern Plains and Western Lakes States would need cost efficiencies to offset higher production costs, compared to Nebraska and Kansas, or would need to produce for a niche market unaffected by the lower operating costs of already established feedlots in the Central and Southern Plains States. Finally, a range of strategies are available in developing value-added cattle production in the Northern Plains and Western Lakes States. These strategies embody differing levels of capital investment, and involve different levels of risk and profitability.cattle feeding, Northern Plains, economies of scale, cooperative ownership, entrance strategies, Production Economics,

Mechanistic analysis of an asymmetric palladium-catalyzed conjugate addition of arylboronic acids to β-substituted cyclic enones.

An asymmetric palladium-catalyzed conjugate addition reaction of arylboronic acids to enone substrates was investigated mechanistically. Desorption electrospray ionization coupled to mass spectrometry was used to identify intermediates of the catalytic cycle and delineate differences in substrate reactivity. Our findings provide evidence for the catalytic cycle proceeding through formation of an arylpalladium(II) cation, subsequent formation of an arylpalladium-enone complex, and, ultimately, formation of the new C-C bond. Reaction monitoring in both positive and negative ion modes revealed that 4-iodophenylboronic acid formed a relatively stable trimeric species under the reaction conditions

A Subaru Weak Lensing Survey I: Cluster Candidates and Spectroscopic Verification

We present the results of an ongoing weak lensing survey conducted with the Subaru telescope whose initial goal is to locate and study the distribution of shear-selected structures or halos. Using a Suprime-cam imaging survey spanning 21.82 square degree, we present a catalog of 100 candidate halos located from lensing convergence maps. Our sample is reliably drawn from that subset of our survey area, (totaling 16.72 square degree) uncontaminated by bright stars and edge effects and limited at a convergence signal to noise ratio of 3.69. To validate the sample detailed spectroscopic measures have been made for 26 candidates using the Subaru multi-object spectrograph, FOCAS. All are confirmed as clusters of galaxies but two arise as the superposition of multiple clusters viewed along the line of sight. Including data available in the literature and an ongoing Keck spectroscopic campaign, a total of 41 halos now have reliable redshifts. For one of our survey fields, the XMM LSS (Pierre et al. 2004) field, we compare our lensing-selected halo catalog with its X-ray equivalent. Of 15 halos detected in the XMM-LSS field, 10 match with published X-ray selected clusters and a further 2 are newly-detected and spectroscopically confirmed in this work. Although three halos have not yet been confirmed, the high success rate within the XMM-LSS field (12/15) confirms that weak lensing provides a reliable method for constructing cluster catalogs, irrespective of the nature of the constituent galaxies or the intracluster medium.Comment: To appear in ApJ, High resolution preprint available at http://anela.mtk.nao.ac.jp/suprime33/papers/p1.ps.g

Selective proteolysis of the wheat Em polypeptide Identification of an endopeptidase activity in germinating wheat embryos

AbstractThe ‘Em’ polypeptide is the most abundant cytosolic polypeptide in mature wheat embryos. It is selectively and completely degraded within the first 24 h of germination. Extracts from germinated embryos contain endopeptidase activities which degrade the Em polypeptide. These are separable into a major and minor component by ion-exchange chromatography and the use of inhibitors shows the major component to be a cysteine proteinase. This activity shows a strong preference for the Em polypeptide as a substrate, being inactive against polypeptides which are not developmentally regulated and showing only low activity towards developmentally related, but otherwise nonhomologous ‘dehydrin’ polypeptides

The disparity between regulatory measurements of E. coli in public bathing waters and the public expectation of bathing water quality

The main objectives of the European Union (EU) Bathing Water Directive (BWD) 2006/7/EC are to safeguard public health and protect designated aquatic environments from microbial pollution. The BWD is implemented through legislation by individual EU Member States and uses faecal indicator organisms (FIOs) as microbial pollution compliance parameters to determine season-end bathing water classifications (either ‘Excellent’ ‘Good’ ‘Sufficient’ or ‘Poor’). These classifications are based on epidemiological studies that have linked human exposure to FIOs with the risk of contracting a gastrointestinal illness (GI). However, understanding public attitudes towards bathing water quality, together with perceptions of relative exposure risks, is often overlooked and yet critically important for informing environmental management decisions at the beach and ensuring effective risk communication. Therefore, this study aimed to determine the effectiveness of current regulatory strategies for informing beach users about bathing water quality, and to assess public understanding of the BWD classifications in terms of exposure risk and public health. Two UK designated bathing waters were selected as case studies, and questionnaires were deployed to beach-users. The bathing waters had different classification histories and both had electronic signage in operation for communicating daily water quality predictions. The majority of respondents did not recognise the standardised EU bathing water quality classification signs, and were unaware of information boards or the electronic signs predicting the water quality on that particular day. In general, respondents perceived the bathing water at their respective beach to be either ‘good’ or ‘sufficient’ which were also the lowest classifications of water quality they would be willing to accept for bathing. However, the lowest level of risk of contracting a gastrointestinal illness that respondents would be willing to accept suggested a significant misunderstanding of the BWD classification system, with the majority (91%) of respondents finding only a < 1% risk level acceptable. The ‘Good’ classification is much less stringent in terms of likelihood of GI. This study has shown that the current public understanding of the BWD classifications in terms of exposure risk and public health is limited, and an investment in methods for disseminating information to the public is needed in order to allow beach-users to make more informed decisions about using bathing waters