The Importance of Capturing Local Measurement-Driven Adjustment of Modelled <i>j</i>(NO₂)

Accurate photolysis rate constants are essential for simulation of local air quality but their values can vary substantially with changes in local meteorological and surface conditions. This study demonstrates the use of local radiometer measurements for capturing via hourly measurement-driven adjustment factors (MDAF) the temporal resolution needed to adjust clear-sky or cloud-free model estimates of j(NO2). Measurements simultaneously at two sites in the UK (Auchencorth Moss and Manchester) showed that TUV (v5.3) model estimates of j(NO2)↓ in cloud-free conditions (used as an example of modelled j-values) were, on average, approximately 45% larger than measured j(NO2)↓, which would lead to substantial model bias in the absence of local adjustment. At Auchencorth Moss, MDAF values based on 4π and 2π radiometer inlets generally agreed very well with each other (<6% average difference). However, under conditions of particularly high surface albedo (such as snow cover), increased upwelling local diffuse radiation yielded an MDAF derived using total radiation (sum of ↓ and ↑ components) ~40% larger than the MDAF derived using only ↓ radiation. The study has demonstrated: (1) the magnitude of potential impact of local conditions—principally cloud cover, but also changes in surface albedo—on assumed j-values; (2) that whilst annual mean MDAF values are similar at Auchencorth Moss and Manchester, there is no contemporaneous correlation between them at hourly resolution; hence MDAF values derived at one site cannot readily be applied at another site. These data illustrate the need to routinely deploy long-term radiometer measurements alongside compositional measurements to support atmospheric chemistry modelling

Ultra-low Ultraviolet Radiation in Office Lighting Can Moderate Seasonal Vitamin D Cycle: A Pilot Study

Background/Aim: Ultraviolet-B (UV-B) radiation initiates vitamin D synthesis in the skin, making sun exposure a major source of vitamin D. We aimed to determine whether office lighting containing ultra-low levels of UV-B radiation could modify the winter decline in vitamin D status in the UK, while being safe and well tolerated. Patients and Methods: Twenty commercial office desk lamps were modified with the addition of UV-B LEDs. Ten hospital office administrative staff received UV-modified lamps with UV-on, and 10 staff received identical placebo lamps with UV switched off, in a double-blind, cross-over pilot study during the winter of 2021/22. Circulating 25-hydroxyvitamin D [25(OH)D] was measured every 4 weeks for 20 weeks: at baseline and during an 8-week trial period, 4-week washout, and a cross-over 8-week trial period. Results: The linear regression combining the complete datasets for phase 1 and 2 of the trial showed that an 8-week UV light intervention significantly increased 25OHD by 7.13 nmol/l with a p-Value=0.02, compared to the placebo group. Similar results were confirmed by cross-over analyses using the datasets of those completing both phases of the trial both with and without using the inverse probability weighing method to handle dropouts. Conclusion: The UV-B-modified lighting was well-tolerated and safe with weekly doses of UV-B of 0.5 - 0.9 Standard Erythema Dose [SED=100 Jm -2 erythema weighted UV radiation] measured at chest level. This ultra-low dosing was effective in reducing the winter decline in vitamin D status

SoDa: a Web service on solar radiation

ISBN 3-9809656-4-3International audienceA Web service has been developed for answering the needs of industry and research for information on solar radiation parameters with a satisfactory quality. It intends to solve the three major problems identified by customers: i) improving access to information, ii) improving knowledge on space and time structure and iii) improving matching of delivered information to actual needs of customers. This service (http://www.soda-is.com) is also innovative with respect to the Internet technologies: it is performing a smart networking of information sources of different natures: databases (radiation, meteorology, elevation, geography...) and algorithms (computation of radiation on slopes, sizing of systems...). These sources were available separately and are geographically dispersed. The service SoDa makes them cooperating and combines them in order to answer to requests, ranging from a series of irradiation values to the sizing of a system

Erratum to: Methods for evaluating medical tests and biomarkers

[This corrects the article DOI: 10.1186/s41512-016-0001-y.]

Evidence synthesis to inform model-based cost-effectiveness evaluations of diagnostic tests: a methodological systematic review of health technology assessments

Background: Evaluations of diagnostic tests are challenging because of the indirect nature of their impact on patient outcomes. Model-based health economic evaluations of tests allow different types of evidence from various sources to be incorporated and enable cost-effectiveness estimates to be made beyond the duration of available study data. To parameterize a health-economic model fully, all the ways a test impacts on patient health must be quantified, including but not limited to diagnostic test accuracy. Methods: We assessed all UK NIHR HTA reports published May 2009-July 2015. Reports were included if they evaluated a diagnostic test, included a model-based health economic evaluation and included a systematic review and meta-analysis of test accuracy. From each eligible report we extracted information on the following topics: 1) what evidence aside from test accuracy was searched for and synthesised, 2) which methods were used to synthesise test accuracy evidence and how did the results inform the economic model, 3) how/whether threshold effects were explored, 4) how the potential dependency between multiple tests in a pathway was accounted for, and 5) for evaluations of tests targeted at the primary care setting, how evidence from differing healthcare settings was incorporated. Results: The bivariate or HSROC model was implemented in 20/22 reports that met all inclusion criteria. Test accuracy data for health economic modelling was obtained from meta-analyses completely in four reports, partially in fourteen reports and not at all in four reports. Only 2/7 reports that used a quantitative test gave clear threshold recommendations. All 22 reports explored the effect of uncertainty in accuracy parameters but most of those that used multiple tests did not allow for dependence between test results. 7/22 tests were potentially suitable for primary care but the majority found limited evidence on test accuracy in primary care settings. Conclusions: The uptake of appropriate meta-analysis methods for synthesising evidence on diagnostic test accuracy in UK NIHR HTAs has improved in recent years. Future research should focus on other evidence requirements for cost-effectiveness assessment, threshold effects for quantitative tests and the impact of multiple diagnostic tests

Erratum to: Methods for evaluating medical tests and biomarkers

[This corrects the article DOI: 10.1186/s41512-016-0001-y.]

Globally Estimated UVB Exposure Times Required to Maintain Sufficiency in Vitamin D Levels

A paucity of vitamin D is a common deficiency globally, with implications for many aspects of health besides the well-known impact on musculoskeletal health. The two sources of vitamin D are through oral intake, or through endogenous synthesis in the skin when exposed to ultraviolet radiation in sunlight. Assessing nutritional needs, whether by food, food fortification or supplementation, is aided by an understanding of local potential for cutaneous synthesis of the vitamin, dependent on latitude and climate, personal skin type and local culture. To aid these discussions we provide indicative exposure times for the maintenance of vitamin D status as a function of latitude, month and skin type, for the clear-sky case and all-sky conditions, for an ambulatory person wearing modest skirt/shorts and T-shirt. At latitudes greater than ±40 degrees, lack of available sunlight limits vitamin D synthesis in some months for all, while at the equator exposure times range from 3 to 15 min at noontime, for white and black skin, respectively. Rather than a sun exposure prescription, the data are intended to show where nutritional vitamin D intake is necessary, advisable, or can be mitigated by sun exposure, and allows for such advice to be personalized to account for different sub-groups in a multicultural population.</p