Testing gravitational parity violation with coincident gravitational waves and short gamma-ray bursts

Gravitational parity violation is a possibility motivated by particle physics, string theory and loop quantum gravity. One effect of it is amplitude birefringence of gravitational waves, whereby left and right circularly-polarized waves propagate at the same speed but with different amplitude evolution. Here we propose a test of this effect through coincident observations of gravitational waves and short gamma-ray bursts from binary mergers involving neutron stars. Such gravitational waves are highly left or right circularly-polarized due to the geometry of the merger. Using localization information from the gamma-ray burst, ground-based gravitational wave detectors can measure the distance to the source with reasonable accuracy. An electromagnetic determination of the redshift from an afterglow or host galaxy yields an independent measure of this distance. Gravitational parity violation would manifest itself as a discrepancy between these two distance measurements. We exemplify such a test by considering one specific effective theory that leads to such gravitational parity-violation, Chern-Simons gravity. We show that the advanced LIGO-Virgo network and all-sky gamma-ray telescopes can be sensitive to the propagating sector of Chern-Simons gravitational parity violation to a level roughly two orders of magnitude better than current stationary constraints from the LAGEOS satellites.Comment: 21 pages, 2 figures, submitted to Phys. Rev.

Ionization, Kinematics, and Extent of the Diffuse Ionized Gas Halo of NGC 5775

We present key results from deep spectra of the Diffuse Ionized Gas (DIG) halo of the edge-on galaxy NGC 5775. [NII]6583 has been detected up to about z=13 kpc above the plane in one of two vertically oriented long slits -- making this the spiral galaxy with the greatest spectroscopically detected halo extent in emission. Key diagnostic line ratios have been measured up to about z=8 kpc, allowing the source of ionization and physical state to be probed. Ionization by a dilute radiation field from massive stars in the disk can explain some of the line ratio behavior, but departures from this picture are clearly indicated, most strongly by the rise of [OIII]/Halpha with z. Velocities of the gas in both slits approach the systemic velocity of the galaxy at several kpc above the plane. We interpret this trend as a decrease in rotation velocity with z, with essentially no rotation at heights of several kpc. Such a trend was observed in the edge-on galaxy NGC 891, but here much more dramatically. This falloff is presumably due to the gravitational potential changing with z, but will also depend on the hydrodynamic nature of the disk-halo cycling of gas and projection effects. More detailed modeling of the ionization and kinematics of this and other edge-ons will be presented in future papers.Comment: figures 1, 2a-d and 3 included. ApJ Letters, in pres

Epitaxial designs for maximizing efficiency in resonant tunnelling diode based terahertz emitters

We discuss the modelling of high current density InGaAs/AlAs/InP resonant tunneling diodes to maximize their efficiency as THz emitters. A figure of merit which contributes to the wall plug efficiency, the intrinsic resonator efficiency, is used for the development of epitaxial designs. With the contribution of key parameters identified, we analyze the limitations of accumulated stress to assess the manufacturability of such designs. Optimal epitaxial designs are revealed, utilizing thin barriers, with a wide and shallow quantum well that satisfies the strained layer epitaxy constraint. We then assess the advantages to epitaxial perfection and electrical characteristics provided by devices with a narrow InAs sub-well inside a lattice-matched InGaAs alloy. These new structures will assist in the realization of the next-generation submillimeter emitters

The multifunctional NS1 protein of influenza A viruses

The non-structural (NS1) protein of influenza A viruses is a non-essential virulence factor that has multiple accessory functions during viral infection. In recent years, the major role ascribed to NS1 has been its inhibition of host immune responses, especially the limitation of both interferon (IFN) production and the antiviral effects of IFN-induced proteins, such as dsRNA-dependent protein kinase R (PKR) and 2'5'-oligoadenylate synthetase (OAS)/RNase L. However, it is clear that NS1 also acts directly to modulate other important aspects of the virus replication cycle, including viral RNA replication, viral protein synthesis, and general host-cell physiology. Here, we review the current literature on this remarkably multifunctional viral protein. In the first part of this article, we summarize the basic biochemistry of NS1, in particular its synthesis, structure, and intracellular localization. We then discuss the various roles NS1 has in regulating viral replication mechanisms, host innate/adaptive immune responses, and cellular signalling pathways. We focus on the NS1-RNA and NS1-protein interactions that are fundamental to these processes, and highlight apparent strain-specific ways in which different NS1 proteins may act. In this regard, the contributions of certain NS1 functions to the pathogenicity of human and animal influenza A viruses are also discussed. Finally, we outline practical applications that future studies on NS1 may lead to, including the rational design and manufacture of influenza vaccines, the development of novel antiviral drugs, and the use of oncolytic influenza A viruses as potential anti-cancer agents.Publisher PDFPeer reviewe

Controlling Stocks and Flows to Promote Quality: The Environment, With Applications to Physical and Human Capital

Our analysis melds two traditional approaches to promoting quality. The first is restoring the stock of quality. The second is curbing its flow of deterioration. Although both approaches are widely used in real world settings, analytic models have tended to focus on one strategy or the other. We consider a class of problems, which we call SFQ' problems, in which both stocks and flows can be controlled to promote quality. We develop our results in the context of environmental quality, drawing on real-world examples from atomic wastes to zebra mussels. But the lessons are general, and we show how they apply to promoting the quality of both physical and human capital. We first study optimal policies in the limiting cases when only abatement or restoration is possible. We then focus on the full SFQ world, where both approaches can be used. We show that the optimal policy employs both instruments. Moreover, when combined optimally, neither strategy takes the form it would in the absence of the other.

Single site observations of \textit{TESS} single transit detections

Context: TESS has been successfully launched and has begin data acquisition. To expedite the science that may be performed with the resulting data it is necessary to gain a good understanding of planetary yields. Given the observing strategy employed by TESS the probability of detecting single transits in long period systems is increased. These systems require careful consideration. Aims: To simulate the number of TESS transit detections during its 2 year mission with a particular emphasis on single transits. Additionally, to determine the feasibility of ground-based follow-up observations from a single site. Methods: A distribution of planets is simulated around the $\sim$ 4 million stars in the TESS Candidate Target List. These planets are tested for detectable transits and characterised. Based on simulated parameters the single transit detections are further analysed to determine which are amenable to ground-based follow-up. Results: TESS will discover an approximate lower bound of 4700 planets with around 460 being single transits. A large fraction of these will be observable from a single ground-based site. This paper finds that, in a single year, approximately 1000 transit events of around 320 unique TESS single transit detections are theoretically observable. Conclusions: As we consider longer period exoplanets the need for exploring single transit detections increases. For periods $\gtrsim45$ days the number of single transit detections outnumber multitransits by a factor of 3 (82$\pm$18 and 25$\pm$7 respectively) a factor which only grows as longer period detections are considered. Therefore, it is worth expending the extra effort required to follow-up these more challenging, but potentially very rewarding, discoveries. Additionally, we conclude that a large fraction of these targets can be theoretically observed from just a single ground-based site.Comment: 12 pages, 19 figures. To be published in Astronomy and Astrophysic

Critical time window for NO-cGMP-dependent long-term memory formation after one-trial appetitive conditioning

The nitric oxide (NO)-cGMP signaling pathway is implicated in an increasing number of experimental models of plasticity. Here, in a behavioral analysis using one-trial appetitive associative conditioning, we show that there is an obligatory requirement for this pathway in the formation of long-term memory (LTM). Moreover, we demonstrate that this requirement lasts for a critical period of ~5 hr after training. Specifically, we trained intact specimens of the snail Lymnaea stagnalis in a single conditioning trial using a conditioned stimulus, amyl-acetate, paired with a salient unconditioned stimulus, sucrose, for feeding. Long-term associative memory induced by a single associative trial was demonstrated at 24 hr and shown to last at least 14 d after training. Tests for LTM and its dependence on NO were performed routinely 24 hr after training. The critical period when NO was needed for memory formation was established by transiently depleting it from the animals at a series of time points after training by the injection of the NO-scavenger 2-phenyl-4,4,5,5-tetramethyl-imidazoline-1-oxyl 3-oxide (PTIO).By blocking the activity of NO synthase and soluble guanylyl cyclase enzymes after training, we provided further evidence that LTM formation depends on an intact NO-cGMP pathway. An electrophysiological correlate of LTM was also blocked by PTIO, showing that the dependence of LTM on NO is amenable to analysis at the cellular level in vitro. This represents the first demonstration that associative memory formation after single-trial appetitive classical conditioning is dependent on an intact NO-cGMP signaling pathway

Some challenges facing logistics education at the new millennium

Although the future of logistics looks bright as the new millennium approaches, logistics programs in higher education face significant changes and challenges. This article examines six challenges—three challenges facing business education in general and three challenges directly and uniquely facing logistics education. Five propositions about the future of logistics education are developed. For logistics education, particularly the traditional logistics programs, the years after the new millennium will be both the best of times and the worst of times